DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and Lrrc4b

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001258010.1	Gene:	Lrrc4b / 308571	RGDID:	1307121	Length:	709	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	106/438 - (24%)
Similarity:	166/438 - (37%)	Gaps:	122/438 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVP-------EYLSPE-----------------VQVLDLSHNHIF 85
            |.|. |...:.. |....|:.||       .||:.:                 :::|.||.|.:.
  Rat    63 CSCS-NQASRVI-CTRRELAEVPASIPVNTRYLNLQENSIQVIRTDTFKHLRHLEILQLSKNLVR 125

  Fly    86 YLEENAF---------------LTT-------HLQNLQKLLIRNGTLKYLNQRSFTQLQILIELD 128
            .:|..||               |||       :|..|::|.:||..::.:...:|.::..|..||
  Rat   126 KIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLD 190

  Fly   129 LSN------------NLLVDL------------LPNVFDCLSKVRAIFLNGNLLQALRHGVFRNL 169
            |..            ..||:|            :||: ..|.::..:.|:||.|..:|.|.|:.|
  Rat   191 LGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNL-TALVRLEELELSGNRLDLIRPGSFQGL 254

  Fly   170 KYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTC 234
            ..|.|:.|...::.:|:..||..:..|.::.|.:|.|..|..:.|..|.:|..:.|..|||:|.|
  Rat   255 TSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNC 319

  Fly   235 DLQMFRDFVIGMNLY---TPPTS------CHYPLQLRGRLWIEDQPEAFAC-KPKIVYPTLSTSI 289
            |       |:.::.:   |.|::      ||.|..|:||...|.....|.| .|.||.|  .|.:
  Rat   320 D-------VLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP--PTDL 375

  Fly   290 N-TSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDV 353
            | |......|.||. |:..|.:.|...|....:..       ..|:.|.:|           ||
  Rat   376 NVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHG-------SYRVRISVL-----------HD- 420

  Fly   354 FVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLID 401
              ..|...|....|.|.|||:..|..|..:...::       .:|.:|
  Rat   421 --GTLNFTNVTVQDTGQYTCMVTNSAGNTTASATL-------NVSAVD 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	11/45 (24%)
		LRR_8	99..158	CDD:290566	18/82 (22%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	10/46 (22%)
		LRR_8	146..206	CDD:290566	17/59 (29%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		TPKR_C2	228..277	CDD:301599	18/58 (31%)
		IG_like	294..390	CDD:214653	21/95 (22%)
		Ig	296..387	CDD:143165	21/90 (23%)
Lrrc4b	NP_001258010.1	LRRNT	59..92	CDD:214470	7/30 (23%)
		LRR	<89..299	CDD:227223	47/210 (22%)
		LRR 1	89..110		2/20 (10%)
		leucine-rich repeat	90..113	CDD:275380	2/22 (9%)
		LRR 2	113..134		7/20 (35%)
		leucine-rich repeat	114..137	CDD:275380	7/22 (32%)
		LRR 3	137..158		3/20 (15%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		LRR 4	161..182		5/20 (25%)
		leucine-rich repeat	162..185	CDD:275380	5/22 (23%)
		LRR 5	185..207		4/21 (19%)
		leucine-rich repeat	186..210	CDD:275380	5/23 (22%)
		LRR 6	210..231		3/21 (14%)
		leucine-rich repeat	211..232	CDD:275380	4/21 (19%)
		LRR 7	232..253		7/20 (35%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		LRR 8	256..277		6/20 (30%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		LRR 9	280..301		6/20 (30%)
		leucine-rich repeat	281..302	CDD:275380	6/20 (30%)
		LRRCT	313..363	CDD:214507	17/56 (30%)
		I-set	366..455	CDD:400151	28/119 (24%)
		Ig strand A	366..369	CDD:409353	1/2 (50%)
		Ig strand A'	373..376	CDD:409353	1/2 (50%)
		Ig strand B	382..389	CDD:409353	2/6 (33%)
		Ig strand C	395..400	CDD:409353	1/4 (25%)
		Ig strand C'	403..405	CDD:409353	0/1 (0%)
		Ig strand D	414..418	CDD:409353	1/3 (33%)
		Ig strand E	421..425	CDD:409353	1/3 (33%)
		Ig strand F	435..442	CDD:409353	3/6 (50%)
		Ig strand G	445..455	CDD:409353	1/16 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..552
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910