DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and Lrrn2

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001170839.1 Gene:Lrrn2 / 289020 RGDID:1305482 Length:750 Species:Rattus norvegicus


Alignment Length:514 Identity:117/514 - (22%)
Similarity:181/514 - (35%) Gaps:185/514 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 WLLDC-GNCHCK---WNSGKK------TADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLE---- 88
            |.:.| ..|.|:   |.:.:.      |.||.:|.|:.||..|....|.|.|..|.|..:|    
  Rat    25 WRVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPGLPAGTQTLLLQSNSISRIEQTEL 89

  Fly    89 ------------ENAF--------------LTTHLQ----------------NLQKLLIRNGTLK 111
                        :|:|              |:.||:                .||:|.:.:..|.
  Rat    90 GYLANLTELDLSQNSFSDARDCDFQALPQLLSLHLEENQLSRLEDHSFAGLTRLQELYLNHNQLC 154

  Fly   112 YLNQRSFTQLQILIELDLSNNLL-------VDLLPNV-----------------FDCLSKVRAIF 152
            .::.|:|..|..|:.|.|::|||       .::|||:                 |..|:.:|::.
  Rat   155 RISPRAFEGLGNLLRLHLNSNLLRTIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLV 219

  Fly   153 ------------------------------------------------LNGNLLQALRHGVFRNL 169
                                                            ||.|.||.:..|.|.|:
  Rat   220 LAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGLKFLDLNKNPLQRVGPGDFANM 284

  Fly   170 KYLHKIELKR-NRLVSIDAKAFVGVPLLSQ-------------------------IYLDNNELTK 208
            .:|.::.|.. ..|||||..|.|.:|.|::                         :.|:||.|:.
  Rat   285 LHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSA 349

  Fly   209 LRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTP-PTSCHYPLQLRGRLWIEDQPE 272
            |..::.:.|..|..:.|..||..|.|.::........:....| .|.|..|..|:.|. :.:.| 
  Rat   350 LHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTHVRFIEPQSTLCAEPPDLQRRP-VREVP- 412

  Fly   273 AFA-----CKPKIVYPTLSTSIN-TSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQK 331
             |.     |.|.|...:..:|:. .|.|::.|.||....|...|.|.....|   |..|.:|.:|
  Rat   413 -FREMTDHCLPLISPRSFPSSLQVASGESLVLHCRALAEPEPEIYWVTPAGV---RLTPARSGRK 473

  Fly   332 QRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVV 390
            .|::.|...|             :.|:|...|     |:|||:|:|..|.|:..:||||
  Rat   474 YRVFPEGTLE-------------LRRVTAEEA-----GLYTCVAQNLVGADTKTVSVVV 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 11/69 (16%)
LRR_8 99..158 CDD:290566 22/130 (17%)
leucine-rich repeat 100..123 CDD:275380 7/22 (32%)
leucine-rich repeat 124..147 CDD:275380 11/46 (24%)
LRR_8 146..206 CDD:290566 23/133 (17%)
leucine-rich repeat 148..171 CDD:275380 9/70 (13%)
leucine-rich repeat 172..195 CDD:275380 9/23 (39%)
leucine-rich repeat 196..219 CDD:275380 7/47 (15%)
TPKR_C2 228..277 CDD:301599 12/54 (22%)
IG_like 294..390 CDD:214653 28/95 (29%)
Ig 296..387 CDD:143165 25/90 (28%)
Lrrn2NP_001170839.1 LRR_RI 46..288 CDD:238064 46/241 (19%)
leucine-rich repeat 51..69 CDD:275380 8/17 (47%)
leucine-rich repeat 71..94 CDD:275380 6/22 (27%)
leucine-rich repeat 95..118 CDD:275380 2/22 (9%)
LRR_8 117..177 CDD:290566 14/59 (24%)
leucine-rich repeat 119..142 CDD:275380 3/22 (14%)
leucine-rich repeat 143..166 CDD:275380 7/22 (32%)
LRR_8 166..222 CDD:290566 12/55 (22%)
leucine-rich repeat 167..190 CDD:275380 7/22 (32%)
leucine-rich repeat 191..214 CDD:275380 2/22 (9%)
LRR_RI 214..>372 CDD:238064 30/157 (19%)
LRR_8 214..273 CDD:290566 4/58 (7%)
leucine-rich repeat 215..238 CDD:275380 1/22 (5%)
leucine-rich repeat 239..262 CDD:275380 0/22 (0%)
leucine-rich repeat 263..286 CDD:275380 8/22 (36%)
leucine-rich repeat 287..311 CDD:275380 9/23 (39%)
LRR_8 310..371 CDD:290566 11/60 (18%)
leucine-rich repeat 312..334 CDD:275380 1/21 (5%)
leucine-rich repeat 337..360 CDD:275378 6/22 (27%)
leucine-rich repeat 361..373 CDD:275378 4/11 (36%)
TPKR_C2 369..412 CDD:301599 10/43 (23%)
I-set 430..514 CDD:254352 30/104 (29%)
Ig 438..514 CDD:299845 28/96 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm9069
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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