DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and SLITRK5

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001371538.1	Gene:	SLITRK5 / 26050	HGNCID:	20295	Length:	958	Species:	Homo sapiens

Alignment Length:	558	Identity:	124/558 - (22%)
Similarity:	196/558 - (35%)	Gaps:	214/558 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LDCG---NCHCKWNSGKKTADCRNLSLSGVPE-----------YLSP------------EVQVLD 78
            |:|.   :|:.:.:......:|:...:..:.|           ||:.            |...||
Human   372 LECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLD 436

  Fly    79 LSH---NHIFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPN 140
            |.|   |.|..:::.||  ..|.||::|.:....::.|:...|..||.|..|.|..||:.::...
Human   437 LLHLGNNRISMIQDRAF--GDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSG 499

  Fly   141 VFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNE 205
            .||.:..::.:|||.|||||:..|||..|..|                         ::.|.:|.
Human   500 TFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLL-------------------------RLNLRSNH 539

  Fly   206 LTKLRVESFQD-LTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIED 269
            .|.|.|....| |..|..:.|.:|||:||||       ::||                 :||:|.
Human   540 FTSLPVSGVLDQLKSLIQIDLHDNPWDCTCD-------IVGM-----------------KLWVEQ 580

  Fly   270 QPEAFACKPKIVYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRI 334
                           |...:...:    :||:.            ..:..|:..:.:||
Human   581 ---------------LKVGVLVDE----VICKA------------PKKFAETDMRSIKS------ 608

  Fly   335 YIELLREDESKIRKFGHDVFVS-----------RLTIVN--ARKSDEGVYTCLAENPGGKDSVHI 386
              |||..|.|       ||.||           |.:.|.  .|.:..|....|... ||..||.:
Human   609 --ELLCPDYS-------DVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAG-GGASSVPL 663

  Fly   387 SVVVQKDMERISLIDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFK----------------- 434
            ||::      :||:  ..|.:...:|.|      ||    .|:.||.|
Human   664 SVLI------LSLL--LVFIMSVFVAAG------LF----VLVMKRRKKNQSDHTSTNNSDVSSF 710

  Fly   435 --QF-----------HPGQHTYLQPTSLP-VQSPGSEEATAISALSSGVIRESKIVLDPLSAINE 485
              |:           ||..|.:.:..:|| |::|            :|.:.|  .:..||..:
Human   711 NMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTP------------AGHVYE--YIPHPLGHM-- 759

  Fly   486 PSNKNYTLFKTSNSNGSEYMHTRNYKDVRLNSNTYTEN 523
              .|| .::::...|..|     :|||:.....||:.|
Human   760 --CKN-PIYRSREGNSVE-----DYKDLHELKVTYSSN 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	9/26 (35%)
		LRR_8	99..158	CDD:290566	18/58 (31%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	15/59 (25%)
		leucine-rich repeat	148..171	CDD:275380	12/22 (55%)
		leucine-rich repeat	172..195	CDD:275380	1/22 (5%)
		leucine-rich repeat	196..219	CDD:275380	7/23 (30%)
		TPKR_C2	228..277	CDD:301599	12/48 (25%)
		IG_like	294..390	CDD:214653	25/108 (23%)
		Ig	296..387	CDD:143165	23/103 (22%)
SLITRK5	NP_001371538.1	leucine-rich repeat	62..79	CDD:275380
		LRR	<72..319	CDD:227223
		LRR 1	82..103
		leucine-rich repeat	83..106	CDD:275380
		LRR 2	106..127
		leucine-rich repeat	107..130	CDD:275380
		LRR_8	129..189	CDD:404697
		LRR 3	130..151
		leucine-rich repeat	131..154	CDD:275380
		LRR 4	154..175
		leucine-rich repeat	155..178	CDD:275380
		LRR 5	178..199
		leucine-rich repeat	179..200	CDD:275380
		LRR 6	201..222
		leucine-rich repeat	202..226	CDD:275380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..358
		PPP1R42	391..>563	CDD:411060	50/198 (25%)
		LRR 7	410..431		2/20 (10%)
		LRR_8	433..493	CDD:404697	20/61 (33%)
		LRR 8	434..455		8/22 (36%)
		leucine-rich repeat	435..458	CDD:275378	9/24 (38%)
		LRR 9	458..479		5/20 (25%)
		leucine-rich repeat	459..482	CDD:275378	5/22 (23%)
		LRR 10	482..503		6/20 (30%)
		leucine-rich repeat	483..530	CDD:275378	19/46 (41%)
		LRR 11	506..527		11/20 (55%)
		LRR 12	529..550		6/45 (13%)
		leucine-rich repeat	531..554	CDD:275378	8/47 (17%)
		leucine-rich repeat	555..567	CDD:275378	5/11 (45%)
		TPKR_C2	563..>599	CDD:417692	15/90 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..844		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000