DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and Lingo2

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001159471.1	Gene:	Lingo2 / 242384	MGIID:	2442298	Length:	606	Species:	Mus musculus

Alignment Length:	601	Identity:	117/601 - (19%)
Similarity:	182/601 - (30%)	Gaps:	265/601 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 CKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGTLK 111
            |:.::..|:..|....|..:||.:..|.::||||.|.                          ||
Mouse    32 CECSAQNKSVSCHRRRLLAIPEGIPIETKILDLSKNR--------------------------LK 70

  Fly   112 YLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHKIE 176
            .:|...|....:|.|:|||:|::.::.|..|:.|..:|::.|.||.|:.:..|||..|..|.|::
Mouse    71 SINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLD 135

  Fly   177 LKRNR------------------------LVSIDAKAFVGVPLLSQIYLDNNELTKLRVE----- 212
            :..|:                        ||.|..:||.|:..|.|:.|:...||.:..|
Mouse   136 ISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHL 200

  Fly   213 ----------------------------------------------------------------- 212

Mouse   201 RSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSITNTNLSTVP 265

  Fly   213 --SFQDLTKLTALSLVENPWNCTCDLQMFRDF-------VIGMNLYT------------------ 250
              :|:.|..||.|:|..||.: |.:..||.|.       ::|..|.|
Mouse   266 FLAFKHLVYLTHLNLSYNPIS-TIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVS 329

  Fly   251 -------------------------PPTSCHYPLQLRGRLW-IEDQPEA---------------- 273
                                     .|.:|...|     || ::.||..
Mouse   330 QNLLETLEENVFSSPRALEVLSINNNPLACDCRL-----LWLLQRQPNLQFGGQQPMCAGPDTIR 389

  Fly   274 ---------------FAC-KPKIVYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESR 322
                           |.| ||||....|...:....:.|.|.|...|.|..||:|
Mouse   390 ERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISW---------- 444

  Fly   323 SKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHIS 387
                  :..:|.:|.......:.:...|      .|.|..|:..|.|:|.|:|.|..|.|:...|
Mouse   445 ------VTPRRRFITTKSNGRATVLGDG------TLEIRFAQDQDSGMYVCIASNAAGNDTFTAS 497

  Fly   388 VVVQ---------KDMERISLIDSN---------------FFAIVCLIAMG---FLSMSILFSLV 425
            :.|:         .:...:.:.|||               ...|:...|||   ||.: :||..:
Mouse   498 LTVKGFTSDRFLYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGV-VLFCFL 561

  Fly   426 TCLIFKRFKQFHPGQH 441
            ...::.|.|    |:|
Mouse   562 LLFVWSRGK----GKH 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	5/23 (22%)
		LRR_8	99..158	CDD:290566	17/58 (29%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_8	146..206	CDD:290566	21/83 (25%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		leucine-rich repeat	172..195	CDD:275380	9/46 (20%)
		leucine-rich repeat	196..219	CDD:275380	8/94 (9%)
		TPKR_C2	228..277	CDD:301599	18/131 (14%)
		IG_like	294..390	CDD:214653	23/95 (24%)
		Ig	296..387	CDD:143165	22/90 (24%)
Lingo2	NP_001159471.1	LRRNT	27..60	CDD:214470	7/27 (26%)
		leucine-rich repeat	39..57	CDD:275380	5/17 (29%)
		LRR 1	58..79		10/46 (22%)
		leucine-rich repeat	59..82	CDD:275380	9/48 (19%)
		LRR_8	60..117	CDD:404697	22/82 (27%)
		LRR 2	82..103		8/20 (40%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		LRR_8	106..165	CDD:404697	12/58 (21%)
		LRR 3	106..127		8/20 (40%)
		leucine-rich repeat	107..130	CDD:275380	9/22 (41%)
		LRR 4	130..151		3/20 (15%)
		leucine-rich repeat	131..154	CDD:275380	3/22 (14%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		PPP1R42	176..>373	CDD:411060	28/202 (14%)
		LRR 6	178..199		6/20 (30%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		LRR 7	202..223		0/20 (0%)
		leucine-rich repeat	203..250	CDD:275380	0/46 (0%)
		LRR 8	226..247		0/20 (0%)
		LRR 9	250..271		1/20 (5%)
		leucine-rich repeat	251..274	CDD:275380	2/22 (9%)
		LRR 10	274..295		9/21 (43%)
		leucine-rich repeat	275..298	CDD:275380	10/23 (43%)
		LRR 11	298..319		3/20 (15%)
		leucine-rich repeat	299..322	CDD:275380	3/22 (14%)
		LRR 12	322..343		0/20 (0%)
		leucine-rich repeat	323..343	CDD:275380	0/19 (0%)
		LRRCT	355..408	CDD:214507	8/57 (14%)
		Ig	411..500	CDD:416386	26/110 (24%)
		Ig strand A'	417..421	CDD:409353	1/3 (33%)
		Ig strand B	427..436	CDD:409353	3/8 (38%)
		Ig strand C	441..446	CDD:409353	3/20 (15%)
		Ig strand C'	449..451	CDD:409353	1/1 (100%)
		Ig strand D	460..463	CDD:409353	0/2 (0%)
		Ig strand E	466..473	CDD:409353	3/12 (25%)
		Ig strand F	479..487	CDD:409353	4/7 (57%)
		Ig strand G	490..500	CDD:409353	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910