DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and Lrfn5

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_848829.2	Gene:	Lrfn5 / 238205	MGIID:	2144814	Length:	746	Species:	Mus musculus

Alignment Length:	803	Identity:	146/803 - (18%)
Similarity:	264/803 - (32%)	Gaps:	262/803 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FLFKIYCLALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHI 84
            |||.::.:.:..|:....     ..|.|:..|......|....|..||..:......|.|:.|.:
Mouse     4 FLFYLFLIGIAVRAQICP-----KRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFV 63

  Fly    85 FYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVR 149
            ..::...|  .::.:|..|.:...|:.::...:|..|:.|..|.|::|.|..:..::|..||.:.
Mouse    64 TNIKRKDF--ANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLH 126

  Fly   150 AIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESF 214
            .:.||.|.|..:....|.::..|.:::|..|.|.:|...|...:..|..:.||:|.:..:...:|
Mouse   127 HLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTF 191

  Fly   215 QDLTKLT-----------------------------------ALSLVENPWNCTCDLQMFRDFVI 244
            ..|.|:|                                   |||...||.:|.|:|...|....
Mouse   192 SHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSR 256

  Fly   245 GMNLYTPPTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTSINTSKENVTLICRVHGSPNTV 309
            ..:|.|    |..|..|.||.:.....|.|.|:|.::............:..||.|:..|.|...
Mouse   257 EDDLET----CASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPA 317

  Fly   310 IAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCL 374
            |.|      .....|.:.:..:..:|      |...:     |:.::.:       .|.|.:||:
Mouse   318 IHW------ISPEGKLISNATRSLVY------DNGTL-----DILITTV-------KDTGAFTCI 358

  Fly   375 AENPGGKDS----VHI---------------------------------------------SVVV 390
            |.||.|:.:    :||                                             .:||
Mouse   359 ASNPAGEATQTVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNASSSNGDTKMSQDKIVV 423

  Fly   391 QKDMERISLIDSNF---------FAI----------------------------------VCLIA 412
            .:.....:|:..||         |.|                                  :|::|
Mouse   424 AEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLASGTMYDLCVLA 488

  Fly   413 M---GFLSMSILFSLVTCLIF---KRFKQFHPGQHTYLQPTSLPVQSPGSEEATAISALSSGVIR 471
            :   |..|::.. .:|.|:.|   :.:.:.|..|..:|..|.:              .:..|:|.
Mouse   489 IYDDGITSLTAT-RVVGCIQFTTEQDYVRCHFMQSQFLGGTMI--------------IIIGGIIV 538

  Fly   472 ESKIVLDPLSAINEPSNKNYTLFKTSNSNGSEYMHTRNYKDVRLNSNTYTENLDNQAESIS---- 532
            .|.:|...:..|.         :|..|:||       .:|..:: ||.|::....|.:..|
Mouse   539 ASVLVFIIILMIR---------YKVCNNNG-------QHKVTKV-SNVYSQTNGAQMQGCSVTLP 586

  Fly   533 -SRNRELYSN--------IAGDREKEELKQKDELDKDSRQSSLQSTGCS---------RKKGQID 579
             |.:::...:        :|.|...:..:.....|..:..|:|..|..|         ||.|...
Mouse   587 QSMSKQAMGHEENAQCCKVASDNAIQSSETCSSQDSSTTTSALPPTWTSSAPVSQKQKRKTGTKP 651

  Fly   580 ELQPDLLPSTQPTALKNINE---------------------TFGPSAKKAEVNP----------- 612
            ..:|      |..|:.|:..                     |.||::::|...|
Mouse   652 SAEP------QSEAVTNVESQNTNRNNSTALQLASCPPDSVTEGPTSQRAHTKPSKFLTVPAEGS 710

  Fly   613 RSKYNTNVQKYLKEK--YGSVRI 633
            |:::..::...||:.  ||:.::
Mouse   711 RARHRASLSGGLKDSFHYGNSQL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	4/23 (17%)
		LRR_8	99..158	CDD:290566	16/58 (28%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	16/59 (27%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	15/48 (31%)
		IG_like	294..390	CDD:214653	21/144 (15%)
		Ig	296..387	CDD:143165	21/139 (15%)
Lrfn5	NP_848829.2	LRR 1	52..73		4/22 (18%)
		leucine-rich repeat	53..76	CDD:275380	4/24 (17%)
		LRR_8	55..111	CDD:338972	13/57 (23%)
		LRR 2	76..97		4/20 (20%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		LRR_8	100..159	CDD:338972	16/58 (28%)
		LRR 3	100..121		6/20 (30%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR 4	124..145		5/20 (25%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		LRR 5	148..169		6/20 (30%)
		LRR_8	149..207	CDD:338972	14/57 (25%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		LRR 6	172..193		5/20 (25%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR 7	196..217		2/20 (10%)
		leucine-rich repeat	197..215	CDD:275380	1/17 (6%)
		TPKR_C2	240..>272	CDD:387596	11/35 (31%)
		Ig_2	301..374	CDD:143241	19/96 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..416		0/30 (0%)
		fn3	421..493	CDD:365830	9/71 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910