DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and FLRT2

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001333072.1	Gene:	FLRT2 / 23768	HGNCID:	3761	Length:	660	Species:	Homo sapiens

Alignment Length:	664	Identity:	127/664 - (19%)
Similarity:	223/664 - (33%)	Gaps:	194/664 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FLFKIYCLALIFRSASADWLLDCGN-CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNH 83
            |..|.:.:..:...:....||.|.: |.|..|    ...|...||:.||..:...|.||.|.:|.
Human    14 FFLKSWLIISLGLYSQVSKLLACPSVCRCDRN----FVYCNERSLTSVPLGIPEGVTVLYLHNNQ 74

  Fly    84 IFYLEENAFLTTHLQNLQK------------------------LLIRNGTLKYLNQRSFTQLQIL 124
            |    .||.....|.|:|.                        |.::...::.:::.:..||..|
Human    75 I----NNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKL 135

  Fly   125 IELDLSNN----------------------------------LLVDL-------------LPNVF 142
            .||.|.:|                                  |.|||             ....|
Human   136 EELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAF 200

  Fly   143 DCLSKVRAIFLNGNLL--QALRHGVFRNL----------------------KYLHKIELKRNRLV 183
            ..|:.:..:.::||||  :.:..|.|.:|                      .:|.::.|:.|::.
Human   201 QNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQIN 265

  Fly   184 SIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFV--IGM 246
            .|...||..:..|.::.:.||:|..|....|.:|:.|..|:...|||.|.|.::...:::  |..
Human   266 HIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPS 330

  Fly   247 NLYTPPTSCHYPLQLRGRLWIEDQPEAFACKP-----KIVYPTLSTSINTSKENVTLI---CRVH 303
            :|......|..|.|:||....|......:|..     .:..|..||:..|::.....|   .|.:
Human   331 SLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSY 395

  Fly   304 GSPN-------TVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIR-------------- 347
            ..|.       |:..||...:|    :.|:    .:||.:.:...:::.|:
Human   396 TPPTPTTSKLPTIPDWDGRERV----TPPI----SERIQLSIHFVNDTSIQVSWLSLFTVMAYKL 452

  Fly   348 ---KFGHDVF--VSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLIDSNFFAI 407
               |.||.:.  :.:..||:..|.                  |:|:|   ::|..|...
Human   453 TWVKMGHSLVGGIVQERIVSGEKQ------------------HLSLV---NLEPRSTYR------ 490

  Fly   408 VCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQHT---YLQPTSLPVQSPGSEEATAISALSSGV 469
            :||:.:...:...:...:...........:.|.:|   :.|.||..:.||     ..::.|..|.
Human   491 ICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSP-----FLLAGLIGGA 550

  Fly   470 IRESKIVLDPLSAINEPSNKNYTLFKTSNSNG---SEYMHTRNYKDVRLNSNTYTENLDNQAESI 531
            :....:||..:...:......||..|...:.|   .:|......||     |:..|..:...:.:
Human   551 VIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKD-----NSILEMTETSFQIV 610

  Fly   532 SSRNRELYSNIAGD 545
            |..|.:|   :.||
Human   611 SLNNDQL---LKGD 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	8/23 (35%)
		LRR_8	99..158	CDD:290566	18/129 (14%)
		leucine-rich repeat	100..123	CDD:275380	4/46 (9%)
		leucine-rich repeat	124..147	CDD:275380	11/69 (16%)
		LRR_8	146..206	CDD:290566	16/83 (19%)
		leucine-rich repeat	148..171	CDD:275380	7/46 (15%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		TPKR_C2	228..277	CDD:301599	13/50 (26%)
		IG_like	294..390	CDD:214653	19/124 (15%)
		Ig	296..387	CDD:143165	18/119 (15%)
FLRT2	NP_001333072.1	LRRNT	35..66	CDD:214470	9/34 (26%)
		NEL	<54..>265	CDD:330839	38/214 (18%)
		LRR 1	64..85		8/24 (33%)
		leucine-rich repeat	65..86	CDD:275378	9/24 (38%)
		LRR 2	89..109		0/19 (0%)
		leucine-rich repeat	90..110	CDD:275380	0/19 (0%)
		LRR 3	110..131		1/20 (5%)
		leucine-rich repeat	111..134	CDD:275380	3/22 (14%)
		LRR 4	134..155		5/20 (25%)
		leucine-rich repeat	135..160	CDD:275380	5/24 (21%)
		LRR 5	160..181		1/20 (5%)
		leucine-rich repeat	161..181	CDD:275380	1/19 (5%)
		leucine-rich repeat	182..205	CDD:275380	3/22 (14%)
		LRR 6	182..202		2/19 (11%)
		LRR 7	205..225		4/19 (21%)
		leucine-rich repeat	206..231	CDD:275380	7/24 (29%)
		LRR 8	231..252		0/20 (0%)
		leucine-rich repeat	232..253	CDD:275380	0/20 (0%)
		LRR_8	252..311	CDD:316378	15/58 (26%)
		LRR 9	253..274		6/20 (30%)
		leucine-rich repeat	254..277	CDD:275380	6/22 (27%)
		LRR 10	277..298		6/20 (30%)
		leucine-rich repeat	278..301	CDD:275380	7/22 (32%)
		PCC	282..>359	CDD:188093	21/76 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..413		8/39 (21%)
		fn3	426..494	CDD:306538	13/94 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910