DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and Lrfn3

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_780687.1 Gene:Lrfn3 / 233067 MGIID:2442512 Length:626 Species:Mus musculus


Alignment Length:385 Identity:88/385 - (22%)
Similarity:140/385 - (36%) Gaps:72/385 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|:..|...:..|....|..||..|......|.|:.|.|..:.....  .::..|..|.:...|
Mouse    32 CRCQTQSMPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIAAVRRRDL--ANMTGLLHLSLSRNT 94

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGV--------- 165
            ::::...:|..|:.|..|.|..|.|..|.......|..:|.:.|:.|.|.||..|.         
Mouse    95 IRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLE 159

  Fly   166 -----FRNLKYL-----------HKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESF 214
                 :.||:.|           :.:.|..|.|.|:.|.||..:..|:::.:.:|.||.:..:..
Mouse   160 DLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPL 224

  Fly   215 QDLTKLTA-----------LSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIE 268
            .....|.|           |:...||.:|.|:|...|......:|    .:|..|..|.||.:..
Mouse   225 FSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDL----EACASPPALGGRYFWA 285

  Fly   269 DQPEAFACKPKIV---YPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQ 330
            ...|.|.|:|.:|   .|.|:.   .:.....|.||..|.|...:.|              .|.|
Mouse   286 VGEEEFVCEPPVVTHRSPPLAV---PAGRPAALRCRAVGDPEPRVRW--------------VSPQ 333

  Fly   331 KQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVV 390
            .:      |..:.|:.|.|.:    ..|.::.....|.|.:||:|.|..|:.:..:.:.|
Mouse   334 GR------LLGNSSRARAFPN----GTLELLVTEPEDGGTFTCIAANAAGEATAAVELTV 383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 4/23 (17%)
LRR_8 99..158 CDD:290566 15/58 (26%)
leucine-rich repeat 100..123 CDD:275380 5/22 (23%)
leucine-rich repeat 124..147 CDD:275380 7/22 (32%)
LRR_8 146..206 CDD:290566 19/84 (23%)
leucine-rich repeat 148..171 CDD:275380 9/36 (25%)
leucine-rich repeat 172..195 CDD:275380 8/33 (24%)
leucine-rich repeat 196..219 CDD:275380 4/22 (18%)
TPKR_C2 228..277 CDD:301599 14/48 (29%)
IG_like 294..390 CDD:214653 20/95 (21%)
Ig 296..387 CDD:143165 20/90 (22%)
Lrfn3NP_780687.1 LRR <63..>222 CDD:227223 37/160 (23%)
leucine-rich repeat 63..84 CDD:275380 4/22 (18%)
LRR 1 84..105 4/20 (20%)
leucine-rich repeat 85..108 CDD:275380 5/22 (23%)
LRR 2 108..129 6/20 (30%)
leucine-rich repeat 109..132 CDD:275380 7/22 (32%)
LRR 3 132..153 7/20 (35%)
leucine-rich repeat 133..157 CDD:275380 7/23 (30%)
LRR 4 157..178 3/20 (15%)
leucine-rich repeat 158..181 CDD:275380 3/22 (14%)
LRR 5 181..202 7/20 (35%)
leucine-rich repeat 182..205 CDD:275380 7/22 (32%)
LRR 6 205..226 4/20 (20%)
leucine-rich repeat 206..230 CDD:275380 4/23 (17%)
leucine-rich repeat 242..253 CDD:275378 3/10 (30%)
TPKR_C2 249..>281 CDD:326558 10/35 (29%)
Ig 310..383 CDD:325142 20/96 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..425 1/2 (50%)
fn3 425..502 CDD:306538
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 590..626
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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