DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and Slit3

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_035542.2	Gene:	Slit3 / 20564	MGIID:	1315202	Length:	1523	Species:	Mus musculus

Alignment Length:	661	Identity:	146/661 - (22%)
Similarity:	241/661 - (36%)	Gaps:	138/661 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |..|......:.||..|.|..||..:....:.|||..|:|..:.:..|  ..|:||:.|.:.:..
Mouse    34 CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDF--AGLKNLRVLHLEDNQ 96

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174
            :..:.:.:|..|:.|..|.|:.|.|..|...:|....|:..:.|:.|.:|.:....||.:..:..
Mouse    97 VSIIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVKN 161

  Fly   175 IELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMF 239
            ::|..|.:..|:..||..:..|..:.|:||.::::.|.||..:.|:..|.|..|...|.|.|...
Mouse   162 LQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWL 226

  Fly   240 RDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFAC------KPKIVYPTLSTSINTSKENVTL 298
            .|::.........|.|..|:.|||....:.|.:.:.|      .|.....:||.....|..|..:
Mouse   227 SDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCSNNIV 291

  Fly   299 ICRVHGSPNTVIAWDYTNQVYESR--SKPVKSLQKQRI--YIELLREDESK--IRKFGHDVF--- 354
            .||  |...|.|..:....:.|.|  ...:||:.....  |.:|.|.|.||  |.....|.|
Mouse   292 DCR--GKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGL 354

  Fly   355 ------------------------VS-RLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDM 394
                                    || :|.::||.|     ..||..|            ..:|:
Mouse   355 KSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANK-----INCLRVN------------TFQDL 402

  Fly   395 ER---ISLIDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQH------------TYL 444
            :.   :||.|:....|         |..:...|      :..:..|..|:            .||
Mouse   403 QNLNLLSLYDNKLQTI---------SKGLFVPL------QSIQTLHLAQNPFVCDCHLKWLADYL 452

  Fly   445 QPTSLPVQSPGSEEAT-------AISALSSGVIR-----------ESKIVLDPLSAINEPSNKNY 491
            |..  |:::.|:..::       .||.:.|...|           .|:..:|.:..  |......
Mouse   453 QDN--PIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFMDLVCP--EKCRCEG 513

  Fly   492 TLFKTSNSNGSEY-MHTRNY-KDVRLNSNTYTENLDNQAESISSRNRELYS-NIAGDREKEELKQ 553
            |:...||...:.. .|...| .|:|||.|..:.   .:|..|..:...|.. |::.:|.||  .:
Mouse   514 TIVDCSNQKLARIPSHLPEYTTDLRLNDNDISV---LEATGIFKKLPNLRKINLSNNRIKE--VR 573

  Fly   554 KDELDKDSRQSSLQSTGCSRKKGQIDELQPDL---LPSTQPTALKN------INETFGPSAKKAE 609
            :...|..:....|..||     .|::.:...:   |.|.:...|::      .|:||   |..:.
Mouse   574 EGAFDGAAGVQELMLTG-----NQLETMHGRMFRGLSSLKTLMLRSNLISCVSNDTF---AGLSS 630

  Fly   610 VNPRSKYNTNV 620
            |...|.|:..:
Mouse   631 VRLLSLYDNRI 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	99..158	CDD:290566	15/58 (26%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	15/59 (25%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		TPKR_C2	228..277	CDD:301599	13/54 (24%)
		IG_like	294..390	CDD:214653	28/129 (22%)
		Ig	296..387	CDD:143165	27/124 (22%)
Slit3	NP_035542.2	LRRNT	33..60	CDD:279764	8/25 (32%)
		LRR_RI	<49..220	CDD:238064	45/172 (26%)
		LRR_8	61..121	CDD:290566	16/61 (26%)
		LRR 1	62..83		6/22 (27%)
		leucine-rich repeat	64..86	CDD:275380	7/23 (30%)
		LRR 2	86..107		4/20 (20%)
		leucine-rich repeat	87..110	CDD:275380	4/22 (18%)
		LRR_8	109..169	CDD:290566	15/59 (25%)
		LRR 3	110..131		7/20 (35%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		LRR 4	134..155		5/20 (25%)
		leucine-rich repeat	135..158	CDD:275380	5/22 (23%)
		LRR_8	157..217	CDD:290566	16/59 (27%)
		LRR 5	158..179		5/20 (25%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		LRR 6	182..203		7/20 (35%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		leucine-rich repeat	207..309	CDD:275380	25/103 (24%)
		LRRNT	280..311	CDD:214470	7/32 (22%)
		LRR 7	308..329		4/20 (20%)
		LRR_8	311..367	CDD:290566	13/55 (24%)
		leucine-rich repeat	311..332	CDD:275380	5/20 (25%)
		LRR_4	331..371	CDD:289563	8/39 (21%)
		LRR 8	332..353		8/20 (40%)
		leucine-rich repeat	333..356	CDD:275380	8/22 (36%)
		LRR_8	355..439	CDD:290566	18/115 (16%)
		LRR 9	356..377		0/20 (0%)
		leucine-rich repeat	357..377	CDD:275380	0/19 (0%)
		LRR 10	380..401		8/37 (22%)
		leucine-rich repeat	381..404	CDD:275380	8/39 (21%)
		LRR 11	404..425		5/29 (17%)
		leucine-rich repeat	405..426	CDD:275380	5/29 (17%)
		leucine-rich repeat	429..522	CDD:275380	17/96 (18%)
		TPKR_C2	437..>467	CDD:301599	5/31 (16%)
		LRRNT	505..535	CDD:214470	6/31 (19%)
		LRR 12	533..554		8/23 (35%)
		leucine-rich repeat	534..558	CDD:275380	7/26 (27%)
		LRR_4	535..574	CDD:289563	12/43 (28%)
		LRR_8	557..617	CDD:290566	13/66 (20%)
		LRR 13	558..579		5/22 (23%)
		leucine-rich repeat	559..582	CDD:275380	6/24 (25%)
		LRR 14	582..603		4/25 (16%)
		leucine-rich repeat	583..606	CDD:275380	5/27 (19%)
		LRR_8	605..665	CDD:290566	9/40 (23%)
		LRR 15	606..627		5/23 (22%)
		leucine-rich repeat	607..630	CDD:275380	5/25 (20%)
		LRR 16	630..651		3/12 (25%)
		leucine-rich repeat	631..654	CDD:275380	3/11 (27%)
		leucine-rich repeat	655..745	CDD:275380
		LRRCT	663..712	CDD:214507
		LRRNT	725..756	CDD:214470
		leucine-rich repeat	746..776	CDD:275380
		LRR_RI	<751..869	CDD:238064
		LRR 17	753..774
		LRR_8	775..835	CDD:290566
		LRR 18	776..797
		leucine-rich repeat	777..800	CDD:275380
		LRR 19	800..821
		leucine-rich repeat	801..824	CDD:275380
		LRR 20	824..845
		leucine-rich repeat	825..846	CDD:275380
		LRRCT	857..906	CDD:214507
		EGF_CA	956..994	CDD:238011
		EGF_CA	998..1031	CDD:238011
EGF_CA	1035..1072	CDD:238011
EGF_CA	1076..1110	CDD:238011
EGF	1123..1153	CDD:278437
Laminin_G_2	1188..1314	CDD:280389
GHB_like	1463..1519	CDD:304424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910