DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and Lrrc4

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_619623.2	Gene:	Lrrc4 / 192198	MGIID:	2182081	Length:	652	Species:	Mus musculus

Alignment Length:	651	Identity:	132/651 - (20%)
Similarity:	227/651 - (34%)	Gaps:	223/651 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KIYCLALIFRSASADWLLDCGN-CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFY 86
            :::.|.....:|::....:|.: |.|. |...|.. |....||.||:.:....:.|:|..|:|..
Mouse    26 QVWILCAAIAAAASAGPQNCPSVCSCS-NQFSKVV-CTRRGLSEVPQGIPSNTRYLNLMENNIQM 88

  Fly    87 LEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAI 151
            ::.:.|  .||.:|:.|.:...:::.:...:|..|..|..|:|.:|.|..:....|:.|||:|.:
Mouse    89 IQADTF--RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLREL 151

  Fly   152 FLNGN-------------------------LLQALRHGVFR---NLKYLH--------------- 173
            :|..|                         .|:.:..|.|.   |||||:
Mouse   152 WLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPL 216

  Fly   174 ----------------------------KIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLR 210
                                        |:.:..:::..|:..||.|:..|.::.|.:|.|:.|.
Mouse   217 VGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLP 281

  Fly   211 VESFQDLTKLTALSLVENPWNCTCDL----QMFRDFVIGMNLYTPPTS------CHYPLQLRGRL 265
            .:.|..|..|..|.|..|||||.||:    ...|:::        ||:      ||.|:.:|||.
Mouse   282 HDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYI--------PTNSTCCGRCHAPMHMRGRY 338

  Fly   266 WIEDQPEAFACKPKIVYPTLSTSINTSKENVT-LICRVHGSPNTVIAWDYTNQVYESRSKPVKSL 329
            .:|....||.|....:... ...:|.|::.:. |.||.  .|.:.:.|...|..       |.|.
Mouse   339 LVEVDQAAFQCSAPFIMDA-PRDLNISEDRMAELKCRT--PPMSSVKWLLPNGT-------VLSH 393

  Fly   330 QKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGK------------- 381
            ..:...|.:|.:.....         ||:.::     |.|||||:..|..|.
Mouse   394 ASRHPRISVLNDGTLNF---------SRVLLI-----DTGVYTCMVTNVAGNSNASAYLNVSSAE 444

  Fly   382 --------------DSVHIS---------------------------VVVQ-------------- 391
                          ::..||                           |::|
Mouse   445 LNTPNFSFFTTVTVETTEISPEDITRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVPVPSTD 509

  Fly   392 -KDMERISL---IDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQHTYLQPTS---- 448
             .|..:.||   :.:....|.|.:|:..|:.::|      ::|.:.::.|..:.|.....:
Mouse   510 TTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAML------IVFYKLRKRHQQRSTVTAARTVEII 568

  Fly   449 -----LPVQSPGSEEATAISALSSGVIRESKIVLDPLSAINEPSNKNYTLFK-------TSNSNG 501
                 :|..:|     .|.:|..|||..|..:||..:.     .:.||..:|       |.||.|
Mouse   569 QVDEDIPAAAP-----AAATAAPSGVSGEGAVVLPTIH-----DHINYNTYKPAHGAHWTENSLG 623

  Fly   502 S 502
            :
Mouse   624 N 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	99..158	CDD:290566	16/83 (19%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	21/130 (16%)
		leucine-rich repeat	148..171	CDD:275380	8/50 (16%)
		leucine-rich repeat	172..195	CDD:275380	6/65 (9%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		TPKR_C2	228..277	CDD:301599	19/58 (33%)
		IG_like	294..390	CDD:214653	23/150 (15%)
		Ig	296..387	CDD:143165	20/118 (17%)
Lrrc4	NP_619623.2	LRRNT	45..78	CDD:214470	10/34 (29%)
		LRR_8	74..132	CDD:290566	14/59 (24%)
		LRR 1	75..96		5/22 (23%)
		leucine-rich repeat	76..99	CDD:275380	7/24 (29%)
		LRR_RI	91..304	CDD:238064	46/214 (21%)
		LRR 2	99..120		3/20 (15%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		LRR 3	123..144		6/20 (30%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..207	CDD:290566	13/60 (22%)
		LRR 4	147..168		4/20 (20%)
		leucine-rich repeat	148..171	CDD:275380	3/22 (14%)
		LRR 5	171..193		3/21 (14%)
		leucine-rich repeat	172..196	CDD:275380	3/23 (13%)
		LRR 6	196..217		5/20 (25%)
		leucine-rich repeat	197..218	CDD:275380	4/20 (20%)
		LRR_8	218..277	CDD:290566	8/58 (14%)
		LRR 7	218..239		0/20 (0%)
		leucine-rich repeat	219..242	CDD:275380	0/22 (0%)
		LRR 8	242..263		4/20 (20%)
		leucine-rich repeat	243..266	CDD:275380	5/22 (23%)
		LRR 9	266..287		6/20 (30%)
		leucine-rich repeat	267..288	CDD:275380	6/20 (30%)
		LRRCT	299..350	CDD:214507	19/58 (33%)
		IG_like	358..440	CDD:214653	22/104 (21%)
		Ig	369..440	CDD:299845	20/93 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910