DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and pxn-1

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_505188.3	Gene:	pxn-1 / 191484	WormBaseID:	WBGene00004256	Length:	1285	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	104/529 - (19%)
Similarity:	162/529 - (30%)	Gaps:	197/529 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IYCLALIFRSASADWLLDCG-NCHCKWNSGKK--TADCRNLSLSGVPEYLSPEVQVLDLSHNHIF 85
            :|.|.|:.  |::.|....| .|..:....||  ..||.:..|:.:|:.:|
Worm     3 LYLLLLVI--ATSSWQFVAGLECPVECTCDKKGLVVDCSSSGLTRIPKNIS-------------- 51

  Fly    86 YLEENAFLTTHLQNLQKLLIRNG---TLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSK 147
                        :|::.|:|||.   .||..:...|.||:.|:   |::|.:..:..||.|.|.:
Worm    52 ------------RNVRSLVIRNNRIHKLKRSDLEGFNQLETLV---LTHNKIKIIEENVLDHLPE 101

  Fly   148 VRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVE 212
            ::.:.|..|.|..: ..:..:.:.|..:.||||.:..||.:.....|.|:|:...:|.:..||.:
Worm   102 LKRLSLAHNELVYI-PPLCSDSRPLASLNLKRNHIQFIDEQVLRYFPDLTQLDFSHNRIQSLRTK 165

  Fly   213 SFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFAC- 276
            .|.:|..|:...|..|||:|.|.....:..:..:. :.....|..|::||.:...|....|..|
Worm   166 LFDNLPALSHAHLHSNPWHCDCRASKVKALLQKVK-WEKKVYCTNPVELRHQALDEVDDSALTCA 229

  Fly   277 ----------------------------------------------------------------- 276

Worm   230 RPAEESWTGEEIKLTCAKNSSSKLVVWMYENVEVDSSSLDGYEIHDTVITVPRKTNVNFMTCTYD 294

  Fly   277 -------------------KPKIVYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESR 322
                               .|:..|.....|.....| |.:.|.|.|:|...|.|.:..:.:.|.
Worm   295 FDHIPHHRRLRQSQHQGNGSPQFTYKPRDNSFREGSE-VKVNCEVMGNPKPTINWYHNGKRFISS 358

  Fly   323 SKPVKSLQKQ--RIYIELLREDE-----------SKIRKF------------------------- 349
            .|....|...  ||| ..|.||.           .|:|..
Worm   359 RKRQLGLSNNVLRIY-PFLEEDSGRYTCEAVNSVGKVRHAFSLDLISSVPPNIYEGPQSVSQNLG 422

  Fly   350 GHDVFV---------------------------------SRLTIVNARKSDEGVYTCLAENPGGK 381
            |..|||                                 :.|.|.|..|.|||.|:|:|.||.|.
Worm   423 GSVVFVCKANGNPVPDYTWSFDGSTIGHIKGRFMVSDDGTELRISNIEKKDEGYYSCMAGNPVGA 487

  Fly   382 DSVHISVVV 390
            .|....:.|
Worm   488 MSADAKLTV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	0/23 (0%)
		LRR_8	99..158	CDD:290566	19/61 (31%)
		leucine-rich repeat	100..123	CDD:275380	9/25 (36%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	14/59 (24%)
		leucine-rich repeat	148..171	CDD:275380	3/22 (14%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		TPKR_C2	228..277	CDD:301599	12/133 (9%)
		IG_like	294..390	CDD:214653	37/166 (22%)
		Ig	296..387	CDD:143165	36/161 (22%)
pxn-1	NP_505188.3	LRRNT	23..51	CDD:279764	7/27 (26%)
		leucine-rich repeat	35..53	CDD:275380	5/43 (12%)
		LRR_8	52..112	CDD:290566	19/62 (31%)
		LRR_4	53..93	CDD:289563	13/42 (31%)
		leucine-rich repeat	54..77	CDD:275380	7/22 (32%)
		LRR_4	77..120	CDD:289563	12/46 (26%)
		leucine-rich repeat	78..101	CDD:275380	8/25 (32%)
		leucine-rich repeat	102..117	CDD:275380	3/15 (20%)
		LRR_8	123..182	CDD:290566	17/58 (29%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		I-set	315..400	CDD:254352	22/86 (26%)
		IGc2	328..392	CDD:197706	17/65 (26%)
		IG_like	414..496	CDD:214653	18/81 (22%)
		Ig	420..496	CDD:299845	18/75 (24%)
		An_peroxidase	634..1181	CDD:281139
		peroxidasin_like	757..1203	CDD:188658
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910