DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and Lrrn2

DIOPT Version :10

Sequence 1:NP_609615.2 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_034862.1 Gene:Lrrn2 / 16980 MGIID:106037 Length:730 Species:Mus musculus


Alignment Length:514 Identity:118/514 - (22%)
Similarity:179/514 - (34%) Gaps:185/514 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 WLLDC-GNCHCK---WNSGKK------TADCRNLSLSGVPEYLSPEVQV---------------- 76
            |.:.| ..|.|:   |.:.:.      |.||.:|.|:.||..|....|.                
Mouse    25 WRVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPRLPAGTQTLLLQSNSISRIDQTEL 89

  Fly    77 --------LDLSHNHI----------------FYLEENAF--LTTH----LQNLQKLLIRNGTLK 111
                    ||||.|..                .:||||..  |..|    |.:||:|.:.:..|.
Mouse    90 AYLANLTELDLSQNSFSDARDCDFQALPQLLSLHLEENRLNRLEDHSFAGLTSLQELYLNHNQLC 154

  Fly   112 YLNQRSFTQLQILIELDLSNNLL-------VDLLPNV-----------------FDCLSKVRAIF 152
            .::.|:|..|..|:.|.|::|||       .::|||:                 |..|:.:|::.
Mouse   155 RISPRAFAGLGNLLRLHLNSNLLRTIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLV 219

  Fly   153 ------------------------------------------------LNGNLLQALRHGVFRNL 169
                                                            ||.|.||.:..|.|.|:
Mouse   220 LAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGLKFLDLNKNPLQRVGPGDFANM 284

  Fly   170 KYLHKIELKR-NRLVSIDAKAFVGVPLLSQ-------------------------IYLDNNELTK 208
            .:|.::.|.. ..|||||..|.|.:|.|::                         :.|:||.|:.
Mouse   285 LHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSA 349

  Fly   209 LRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTP-PTSCHYPLQLRGRLWIEDQPE 272
            |..::.:.|..|..:.|..||..|.|.::........:....| .|.|..|..|:.|. :.:.| 
Mouse   350 LHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTHVRFIEPQSTLCAEPPDLQRRP-VREVP- 412

  Fly   273 AFA-----CKPKIVYPTLSTSIN-TSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQK 331
             |.     |.|.|...:..:|:. .|.|:..|.||....|...|.|.....|   |..|.:|.::
Mouse   413 -FREMTDHCLPLISPRSFPSSLQIASGESTVLHCRALAEPEPEIYWVTPAGV---RLTPARSGRR 473

  Fly   332 QRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVV 390
            .|::.|...|             :.|:|...|     |:|||:|:|..|.|:..:||||
Mouse   474 YRVFPEGTLE-------------LRRVTAEEA-----GLYTCVAQNLVGADTKTVSVVV 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_609615.2 LRR 59..>228 CDD:443914 64/312 (21%)
leucine-rich repeat 75..99 CDD:275380 13/69 (19%)
LRR_8 98..158 CDD:404697 22/131 (17%)
leucine-rich repeat 100..123 CDD:275380 7/22 (32%)
leucine-rich repeat 124..147 CDD:275380 11/46 (24%)
leucine-rich repeat 148..171 CDD:275380 9/70 (13%)
leucine-rich repeat 172..195 CDD:275380 9/23 (39%)
leucine-rich repeat 196..219 CDD:275380 7/47 (15%)
LRRCT 228..277 CDD:214507 12/54 (22%)
IG_like 294..390 CDD:214653 27/95 (28%)
Ig strand B 296..300 CDD:409353 1/3 (33%)
Ig strand C 309..323 CDD:409353 3/13 (23%)
Ig strand E 356..360 CDD:409353 1/3 (33%)
Ig strand F 370..375 CDD:409353 3/4 (75%)
Ig strand G 383..386 CDD:409353 0/2 (0%)
Lrrn2NP_034862.1 LRRNT 28..72 CDD:214470 12/43 (28%)
leucine-rich repeat 51..69 CDD:275380 8/17 (47%)
leucine-rich repeat 71..94 CDD:275380 1/22 (5%)
LRR <85..>324 CDD:443914 50/238 (21%)
leucine-rich repeat 95..118 CDD:275380 5/22 (23%)
leucine-rich repeat 119..142 CDD:275380 7/22 (32%)
leucine-rich repeat 143..166 CDD:275380 7/22 (32%)
leucine-rich repeat 167..190 CDD:275380 7/22 (32%)
leucine-rich repeat 191..214 CDD:275380 2/22 (9%)
leucine-rich repeat 215..238 CDD:275380 1/22 (5%)
leucine-rich repeat 239..262 CDD:275380 0/22 (0%)
leucine-rich repeat 263..286 CDD:275380 8/22 (36%)
leucine-rich repeat 287..311 CDD:275380 9/23 (39%)
LRR_8 310..371 CDD:404697 11/60 (18%)
leucine-rich repeat 312..334 CDD:275380 1/21 (5%)
leucine-rich repeat 337..360 CDD:275378 6/22 (27%)
PCC 342..>420 CDD:188093 20/80 (25%)
leucine-rich repeat 361..373 CDD:275378 4/11 (36%)
Ig 430..514 CDD:472250 29/104 (28%)
Ig strand B 441..445 CDD:409421 1/3 (33%)
Ig strand C 454..458 CDD:409421 1/3 (33%)
Ig strand E 480..484 CDD:409421 1/16 (6%)
Ig strand F 494..499 CDD:409421 3/4 (75%)
Ig strand G 507..510 CDD:409421 0/2 (0%)

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