DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek4 and LRFN5

DIOPT Version :10

Sequence 1:NP_609615.2 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_689660.2 Gene:LRFN5 / 145581 HGNCID:20360 Length:719 Species:Homo sapiens


Alignment Length:756 Identity:145/756 - (19%)
Similarity:254/756 - (33%) Gaps:241/756 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|:..|......|....|..||..:......|.|:.|.:..::...|  .::.:|..|.:...|
Human    24 CVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDF--ANMTSLVDLTLSRNT 86

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174
            :.::...:|..|:.|..|.|::|.|..:..::|..||.:..:.||.|.|..:....|.::..|.:
Human    87 ISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEE 151

  Fly   175 IELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLT------------------ 221
            ::|..|.|.:|...|...:..|..:.||:|.:..:...:|..|.|:|                  
Human   152 LDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLF 216

  Fly   222 -----------------ALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIED 269
                             |||...||.:|.|:|...|......:|.|    |..|..|.||.:...
Human   217 QRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLET----CASPPLLTGRYFWSI 277

  Fly   270 QPEAFACKPKIVYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRI 334
            ..|.|.|:|.::............:..||.|:..|.|...|.|      .....|.:.:..:..:
Human   278 PEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHW------ISPEGKLISNATRSLV 336

  Fly   335 YIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDS----VHI--------- 386
            |      |...:     |:.::.:       .|.|.:||:|.||.|:.:    :||         
Human   337 Y------DNGTL-----DILITTV-------KDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNS 383

  Fly   387 ------------------------------------SVVVQKDMERISLIDSNF---------FA 406
                                                .:||.:.....:|:..||         |.
Human   384 TNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEATSSTALLKFNFQRNIPGIRMFQ 448

  Fly   407 I----------------------------------VCLIAM---GFLSMSILFSLVTCLIF---K 431
            |                                  :|::|:   |..|::.. .:|.|:.|   :
Human   449 IQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCVLAIYDDGITSLTAT-RVVGCIQFTTEQ 512

  Fly   432 RFKQFHPGQHTYLQPTSLPVQSPGSEEATAISALSSGVIRESKIVLDPLSAINEPSNKNYTLFKT 496
            .:.:.|..|..:|..|.:              .:..|:|..|.:|...:..|.         :|.
Human   513 DYVRCHFMQSQFLGGTMI--------------IIIGGIIVASVLVFIIILMIR---------YKV 554

  Fly   497 SNSNGSEYMHTRNYKDVRLNSNTYTENLDNQAESISSRNRELYSNIAGDREK---------EELK 552
            .|:||       .:|..:: ||.|::....|.:..|....:..|..|...|:         :.:.
Human   555 CNNNG-------QHKVTKV-SNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENAQCCKATSDNVI 611

  Fly   553 QKDEL----DKDSRQSSL-----QSTGCSRKKGQIDELQPDLLPSTQP--TALKNINE------- 599
            |..|.    |..:..|:|     .||..|:|:    :.:....|||:|  .|:.|:..       
Human   612 QSSETCSSQDSSTTTSALPPSWTSSTSVSQKQ----KRKTGTKPSTEPQNEAVTNVESQNTNRNN 672

  Fly   600 --------------TFGPSAKKAEVNPRSKYNTNVQKYLKE 626
                          |.||::|:|.:.|.:.. |||.:.::|
Human   673 STALQLASRPPDSVTEGPTSKRAHIKPNALL-TNVDQIVQE 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_609615.2 LRR 59..>228 CDD:443914 42/203 (21%)
leucine-rich repeat 75..99 CDD:275380 4/23 (17%)
LRR_8 98..158 CDD:404697 16/59 (27%)
leucine-rich repeat 100..123 CDD:275380 5/22 (23%)
leucine-rich repeat 124..147 CDD:275380 7/22 (32%)
leucine-rich repeat 148..171 CDD:275380 5/22 (23%)
leucine-rich repeat 172..195 CDD:275380 6/22 (27%)
leucine-rich repeat 196..219 CDD:275380 6/22 (27%)
LRRCT 228..277 CDD:214507 15/48 (31%)
IG_like 294..390 CDD:214653 21/144 (15%)
Ig strand B 296..300 CDD:409353 2/3 (67%)
Ig strand C 309..323 CDD:409353 2/13 (15%)
Ig strand E 356..360 CDD:409353 0/3 (0%)
Ig strand F 370..375 CDD:409353 2/4 (50%)
Ig strand G 383..386 CDD:409353 0/6 (0%)
LRFN5NP_689660.2 LRR 1 52..73 4/22 (18%)
leucine-rich repeat 53..76 CDD:275380 4/24 (17%)
LRR <69..>211 CDD:443914 33/143 (23%)
LRR 2 76..97 4/20 (20%)
leucine-rich repeat 77..100 CDD:275380 5/22 (23%)
LRR 3 100..121 6/20 (30%)
leucine-rich repeat 101..124 CDD:275380 7/22 (32%)
LRR 4 124..145 5/20 (25%)
leucine-rich repeat 125..148 CDD:275380 5/22 (23%)
LRR 5 148..169 6/20 (30%)
leucine-rich repeat 149..172 CDD:275380 6/22 (27%)
LRR 6 172..193 5/20 (25%)
leucine-rich repeat 173..196 CDD:275380 6/22 (27%)
LRR 7 196..217 2/20 (10%)
leucine-rich repeat 197..215 CDD:275380 1/17 (6%)
LRRCT 240..>272 CDD:214507 11/35 (31%)
IgI_SALM5_like 287..374 CDD:409421 19/110 (17%)
Ig strand A 287..290 CDD:409421 0/2 (0%)
Ig strand A' 294..297 CDD:409421 0/2 (0%)
Ig strand B 303..311 CDD:409421 3/7 (43%)
Ig strand C 317..322 CDD:409421 2/10 (20%)
Ig strand C' 325..327 CDD:409421 0/1 (0%)
Ig strand D 333..337 CDD:409421 0/3 (0%)
Ig strand E 340..344 CDD:409421 0/8 (0%)
Ig strand F 354..361 CDD:409421 3/6 (50%)
Ig strand G 364..374 CDD:409421 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..414 0/28 (0%)
FN3 421..494 CDD:473895 9/72 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..694 17/82 (21%)

Return to query results.
Submit another query.