DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and LRRN2

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_006329.2	Gene:	LRRN2 / 10446	HGNCID:	16914	Length:	713	Species:	Homo sapiens

Alignment Length:	514	Identity:	118/514 - (22%)
Similarity:	179/514 - (34%)	Gaps:	185/514 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 WLLDC-GNCHCK---WNSGKK------TADCRNLSLSGVPEYLSPEVQV---------------- 76
            |.:.| ..|.|:   |.:.:.      |.||.:|.|:.||..|....|.
Human    25 WHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSEL 89

  Fly    77 --------LDLSHNHI----------------FYLEENAF--LTTH----LQNLQKLLIRNGTLK 111
                    ||||.|..                .:||||..  |..|    |.:||:|.:.:..|.
Human    90 GYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLY 154

  Fly   112 YLNQRSFTQLQILIELDLSNNLL-------VDLLPNV-----------------FDCLSKVRAIF 152
            .:..|:|:.|..|:.|.|::|||       .::|||:                 |..|:.:|::.
Human   155 RIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLV 219

  Fly   153 ------------------------------------------------LNGNLLQALRHGVFRNL 169
                                                            ||.|.||.:..|.|.|:
Human   220 LAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANM 284

  Fly   170 KYLHKIELKR-NRLVSIDAKAFVGVPLLSQ-------------------------IYLDNNELTK 208
            .:|.::.|.. ..|||||..|.|.:|.|::                         :.|:||.|:.
Human   285 LHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSA 349

  Fly   209 LRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTP-PTSCHYPLQLRGRLWIEDQPE 272
            |..::.:.|..|..:.|..||..|.|.::........:....| .|.|..|..|: ||.:.:.|
Human   350 LHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQ-RLPVREVP- 412

  Fly   273 AFA-----CKPKIVYPTLSTSIN-TSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQK 331
             |.     |.|.|...:...|:. .|.|::.|.||....|...|.|.....:   |..|..:.::
Human   413 -FREMTDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGL---RLTPAHAGRR 473

  Fly   332 QRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVV 390
            .|:|.|...|             :.|:|...|     |:|||:|:|..|.|:..:||||
Human   474 YRVYPEGTLE-------------LRRVTAEEA-----GLYTCVAQNLVGADTKTVSVVV 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	13/69 (19%)
		LRR_8	99..158	CDD:290566	22/130 (17%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	11/46 (24%)
		LRR_8	146..206	CDD:290566	23/133 (17%)
		leucine-rich repeat	148..171	CDD:275380	9/70 (13%)
		leucine-rich repeat	172..195	CDD:275380	9/23 (39%)
		leucine-rich repeat	196..219	CDD:275380	7/47 (15%)
		TPKR_C2	228..277	CDD:301599	13/54 (24%)
		IG_like	294..390	CDD:214653	26/95 (27%)
		Ig	296..387	CDD:143165	23/90 (26%)
LRRN2	NP_006329.2	leucine-rich repeat	51..69	CDD:275380	8/17 (47%)
		LRR_RI	62..288	CDD:238064	43/225 (19%)
		LRR 1	70..91		1/20 (5%)
		leucine-rich repeat	71..94	CDD:275380	1/22 (5%)
		LRR 2	94..115		5/20 (25%)
		leucine-rich repeat	95..118	CDD:275380	5/22 (23%)
		LRR_8	117..177	CDD:290566	18/59 (31%)
		LRR 3	118..139		6/20 (30%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		LRR 4	142..163		6/20 (30%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		LRR_8	165..222	CDD:290566	12/56 (21%)
		LRR 5	166..187		6/20 (30%)
		leucine-rich repeat	167..190	CDD:275380	7/22 (32%)
		LRR 6	190..211		2/20 (10%)
		leucine-rich repeat	191..214	CDD:275380	2/22 (9%)
		LRR_RI	209..>372	CDD:238064	32/162 (20%)
		LRR_8	214..273	CDD:290566	4/58 (7%)
		LRR 7	214..235		1/20 (5%)
		leucine-rich repeat	215..238	CDD:275380	1/22 (5%)
		LRR 8	238..259		0/20 (0%)
		leucine-rich repeat	239..262	CDD:275380	0/22 (0%)
		LRR 9	262..283		7/20 (35%)
		leucine-rich repeat	263..286	CDD:275380	8/22 (36%)
		LRR 10	286..305		7/18 (39%)
		leucine-rich repeat	287..311	CDD:275380	9/23 (39%)
		LRR_8	310..371	CDD:290566	11/60 (18%)
		LRR 11	311..333		1/21 (5%)
		leucine-rich repeat	312..334	CDD:275380	1/21 (5%)
		LRR 12	336..357		5/20 (25%)
		leucine-rich repeat	337..360	CDD:275378	6/22 (27%)
		leucine-rich repeat	361..373	CDD:275378	4/11 (36%)
		TPKR_C2	369..412	CDD:301599	11/43 (26%)
		I-set	430..514	CDD:254352	28/104 (27%)
		Ig	438..514	CDD:299845	26/96 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910