DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and lrfn3

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:XP_017951836.1 Gene:lrfn3 / 100497711 XenbaseID:XB-GENE-923381 Length:632 Species:Xenopus tropicalis


Alignment Length:576 Identity:127/576 - (22%)
Similarity:207/576 - (35%) Gaps:163/576 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 CLALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYL---SPEVQVLD--------- 78
            ||.:|  |.|...::....|.|:..|...|..|....|..||..:   :.|::::|         
 Frog     7 CLLMI--STSVKTMMCPKRCSCQNVSPSITILCTKTGLLFVPPTIDRRTAELRLMDNFITTLRRR 69

  Fly    79 ------------LSHN----------------HIFYLEENAFLTT---HLQ---NLQKLLIRNGT 109
                        ||.|                |..:|:.|...:.   ||:   ||:.|::.|..
 Frog    70 DFANMTDLIHLTLSRNTISQIMPYAFVDLKGLHALHLDSNRLTSVSEEHLRGLINLRHLILSNNQ 134

  Fly   110 LKYLNQRSFTQ-LQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLH 173
            |.|:...||.. :..|.:||||.|.|||:.......||.|..:.|:.||:..:..|:|.||..|.
 Frog   135 LHYIAPGSFDDFVDTLEDLDLSYNNLVDIPWETIGRLSSVNTVGLDHNLIDYVPEGIFSNLHKLA 199

  Fly   174 KIELKRNRLVSIDAKAFVGVPLLSQIYL----DNNELTKLRVESFQDLTKLTALSLVENPWNCTC 234
            ::::..|:|..|...     ||.|:|.:    ..:.||.|            .||...||.:|.|
 Frog   200 RLDMTSNKLKKIPPD-----PLFSRIPVYAKSKGSPLTSL------------VLSFGGNPLHCNC 247

  Fly   235 DLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTSINTSKENVTLI 299
            :|...|......:|.|    |..|.:|.|:.:...:.|.|.|:|.::....|..:....::.:|.
 Frog   248 ELMWLRRLTREDDLET----CASPAELMGKYFWSIKEEEFVCEPPMITHRTSKLVIMEGQSASLK 308

  Fly   300 CRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNAR 364
            |:..|.|:..:.|      .....|.|.:..:...|..                  ..|.|:...
 Frog   309 CKSVGDPDPYVRW------ISPDGKLVSNTSRTMSYDN------------------GTLDIITTI 349

  Fly   365 KSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLIDSNFFAIVCLIAMGFLSMSILFSLVTCLI 429
            .:|.|.:||:|.|..|:.:.::.:.|.                         ....|.:...|  
 Frog   350 YADRGNFTCIASNAAGESTANVELTVN-------------------------PFPNLANSTNC-- 387

  Fly   430 FKRFKQFHPGQHTYLQPTSLPVQSPGSE------------EATAISALSSGVIRESKIVLDPLSA 482
               .|:...|....|.|....:  |.||            |.|:.|||         |...|.|.
 Frog   388 ---DKETESGLSDILTPAKSSI--PSSETKALNDKKVVVAELTSSSAL---------IQWPPQSH 438

  Fly   483 INEPSNKNYTLFKTSNSNGSEYMHTRNYKDVRLNSNTYTENLDNQAESISSRNREL 538
            |  |..:.|.:  ..||:..:.:   .|:.:..:|.::.     .::.:||||.:|
 Frog   439 I--PGIRMYQI--QYNSSSDDIL---IYRMIPSSSKSFF-----LSDLVSSRNYDL 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 9/66 (14%)
LRR_8 99..158 CDD:290566 22/59 (37%)
leucine-rich repeat 100..123 CDD:275380 7/23 (30%)
leucine-rich repeat 124..147 CDD:275380 10/22 (45%)
LRR_8 146..206 CDD:290566 17/63 (27%)
leucine-rich repeat 148..171 CDD:275380 8/22 (36%)
leucine-rich repeat 172..195 CDD:275380 4/22 (18%)
leucine-rich repeat 196..219 CDD:275380 5/26 (19%)
TPKR_C2 228..277 CDD:301599 14/48 (29%)
IG_like 294..390 CDD:214653 17/95 (18%)
Ig 296..387 CDD:143165 17/90 (19%)
lrfn3XP_017951836.1 LRR_8 55..111 CDD:338972 8/55 (15%)
leucine-rich repeat 55..76 CDD:275380 2/20 (10%)
leucine-rich repeat 77..100 CDD:275380 3/22 (14%)
LRR_8 100..160 CDD:338972 19/59 (32%)
leucine-rich repeat 101..124 CDD:275380 5/22 (23%)
leucine-rich repeat 125..148 CDD:275380 7/22 (32%)
LRR_8 149..208 CDD:338972 21/58 (36%)
leucine-rich repeat 150..173 CDD:275380 10/22 (45%)
leucine-rich repeat 174..197 CDD:275380 8/22 (36%)
leucine-rich repeat 198..233 CDD:275380 9/39 (23%)
TPKR_C2 241..>270 CDD:387596 10/32 (31%)
Ig 302..375 CDD:386229 17/96 (18%)
fn3 419..491 CDD:365830 20/85 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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