DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and lrrc15

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_031758235.1	Gene:	lrrc15 / 100496322	XenbaseID:	XB-GENE-990725	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	475	Identity:	95/475 - (20%)
Similarity:	171/475 - (36%)	Gaps:	138/475 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDL 137
            :::.|.||:|.|..:..:.|  |.|.|::.|.:....|:.:...:|.|:..|::|:|:.|.:..|
Frog   124 KLETLILSNNQINQIHPSLF--TALSNVKDLQMVGNNLESIPVGAFDQMSGLLKLNLAKNSIKYL 186

  Fly   138 LPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLD 202
            .|..||.|:|::.:.|..|.||.:..|..:.|..|.::.|..|:|:.:....|.|.|.|.:::|.
Frog   187 PPQAFDKLAKLQTLRLYENQLQDIPAGFLKKLSSLQEVALHSNKLIELSTDTFSGNPYLQKVFLS 251

  Fly   203 NNELTKLRVESFQDLTKLTALSLVENP------------------WNCTCDLQMFRD-------- 241
            |||:..|....|.:|.::|.|:|..|.                  |.....|:...|
Frog   252 NNEIDSLPRGIFLNLPEITKLTLYGNALRELTTGVFGPMPKLKELWLYDNQLEQLTDNVFSNLTE 316

  Fly   242 ---FVIGMNLYTPPTSCH--------YPLQLRGRLWIEDQPEAFACKPKI--------------- 280
               .||..|... ..|.|        ..|.|...|......:...|.||:
Frog   317 TVLLVISKNKIR-SISTHAFCGLEELQELSLHTNLLTTLDQDVLKCLPKLQNISLHSNKIQYLPG 380

  Fly   281 -VYPTLSTSINTSKENVTLICRVHGSPNTVI----------AW--DYT-----NQVYESRSK--- 324
             ::..:.|.:|...:|.:|....|...::::          .|  |:.     |.:.|:.:|
Frog   381 DLFKNMDTVMNIQLQNNSLEDIPHDFFDSLVQLNEVKLYENPWKCDHNLLSLKNWLSENMNKLGN 445

  Fly   325 --------------PVKSLQKQRI-YIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVY-TC 373
                          |:..|..::: |.:...|.:.....|.:|.           .|.:..| |.
Frog   446 LSQLVCTNSPFNGIPISELSDEQLTYQDFTVEPDLFHSTFNYDT-----------SSPDKTYPTA 499

  Fly   374 LAENPGGKDSVHISVVVQKDMERISLIDSNF---------------------FAIVCLIAMGFLS 417
            ....|.....:|       |:|.:|::|...                     ..::|.||
Frog   500 STPRPTDTTMIH-------DLEDVSMMDETLVPDDDTKDHDRGNMVGGVVIAIIVLCCIA----- 552

  Fly   418 MSILFSLVTCLIFKRFKQFH 437
              ::.:.:.|::|.|.|:.|
Frog   553 --LVAAAIACILFNRRKKSH 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	8/23 (35%)
		LRR_8	99..158	CDD:290566	17/58 (29%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_8	146..206	CDD:290566	18/59 (31%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		TPKR_C2	228..277	CDD:301599	12/85 (14%)
		IG_like	294..390	CDD:214653	19/131 (15%)
		Ig	296..387	CDD:143165	18/126 (14%)
lrrc15	XP_031758235.1	leucine-rich repeat	35..51	CDD:275380
		LRR_8	51..111	CDD:404697
		leucine-rich repeat	54..76	CDD:275380
		leucine-rich repeat	77..100	CDD:275380
		internalin_A	98..>449	CDD:380193	72/327 (22%)
		leucine-rich repeat	101..124	CDD:275380	95/475 (20%)
		leucine-rich repeat	125..148	CDD:275380	8/24 (33%)
		leucine-rich repeat	149..172	CDD:275380	4/22 (18%)
		leucine-rich repeat	173..196	CDD:275380	9/22 (41%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		leucine-rich repeat	221..244	CDD:275380	6/22 (27%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		leucine-rich repeat	269..292	CDD:275380	4/22 (18%)
		leucine-rich repeat	293..316	CDD:275380	3/22 (14%)
		leucine-rich repeat	317..340	CDD:275380	5/23 (22%)
		leucine-rich repeat	341..362	CDD:275380	3/20 (15%)
		leucine-rich repeat	365..388	CDD:275380	0/22 (0%)
		leucine-rich repeat	389..410	CDD:275380	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000