Protein Alignment kek4 and lrrc4

DIOPT Version :10

• Sequence 1: NP_609615.2
• Gene: kek4 / 34718
• FlyBaseID: FBgn0032484
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_002939414.1
• Gene: lrrc4 / 100493671
• XenbaseID: XB-GENE-968937
• Length: 641
• Species: Xenopus tropicalis
• Alignment Length: 690
• Identity: 136/690 - (19%)
• Similarity: 234/690 - (33%)
• Gaps: 233/690 - (33%)

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|. |...|.. |....||.||:.:....:.|:|..|:|..::.:.|  .||.:|:.|.:...:
 Frog    44 CSCS-NQFSKVV-CTRRGLSEVPQGIPSNTRSLNLMENNIQMIQADTF--RHLHHLEVLQLGRNS 104

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGN------------------ 156
            ::.:...:|..|..|..|:|.:|.|..:....|:.|||:|.::|..|
 Frog   105 IRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMR 169

  Fly   157 -------LLQALRHGVFR---NLKYLH-------------------KIELKRNRLVSIDAKAFVG 192
                   .|:.:..|.|.   |||||:                   ::|:..|....|...:|.|
 Frog   170 LDLGELKKLEYISEGAFEGLYNLKYLNLGMCNIRDMPNLTPLVGLEELEISGNNFPEIKPGSFHG 234

  Fly   193 VPLLSQIYLDNNELTKLRVESFQDLTKLTALSLV------------------------ENPWNCT 233
            :..|.::::.|:::..:...:|.|||.|..|:|.                        .|||:|.
 Frog   235 LRSLKKLWIMNSQINTIERNAFDDLTSLVELNLAHNNVTSLPHDLFAPLKYLVELHLHHNPWDCD 299

  Fly   234 CDL----QMFRDFVIGMNLYTPPTS------CHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTS 288
            ||:    ...|:::        ||:      ||.|..:||:..:|.....|.|....:... ...
 Frog   300 CDVLWLSWWLREYI--------PTNSTCCGRCHSPPHMRGKYVVEVDHSMFQCSAPFIMDA-PRD 355

  Fly   289 INTSKENVT-LICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHD 352
            :|.|:..:. |.||.  |..:.:.|                         ||...........|
 Frog   356 LNISEGRMAELKCRT--SAMSSVRW-------------------------LLPNGTVLTHASNH- 392

  Fly   353 VFVSRLTIVN--------ARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLIDSNFFAIVC 409
               .|:||:|        ...:|.|||||:..|..|..:.  |..:......::..:.:||..|.
 Frog   393 ---PRITILNDGTLNFSQVLLTDTGVYTCMVTNVAGNSNA--SAYLNVSTAELNTSNYSFFTTVT 452

  Fly   410 L----IAMGFLSMSILFSLVTCLIFKRFKQFHPG-QHTYLQPTSLPVQSPGSEEATAISALSSG- 468
            :    :|...:||          |||.......| |..|...|::.:|:....:..|:....:|
 Frog   453 VETTEVAPEDISM----------IFKPVPTTSTGYQPAYTTTTTVLIQTTKMPKQVAVPTSDAGD 507

  Fly   469 --------VIRESKIVLDPLSAINEPSNKNYTLFKTSNSNGSEYMHTRNYKDVRLNSNTYTENLD 525
                    |::.:||::....|:...:.....:|               ||
 Frog   508 KMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVF---------------YK-------------- 543

  Fly   526 NQAESISSRNRELYSNIAGDREKEELKQKDELDKDSRQSSLQSTGCSRKKGQIDELQPDLLPSTQ 590
                 :..|::: .|.:|..|..|.:    ::|:|                         :||..
 Frog   544 -----LRKRHQQ-RSTVAAARTVEII----QVDED-------------------------IPSGS 573

  Fly   591 PTALKNINETFGPSAKKAEVNPRSKYNTNVQKYLKEKYGS 630
            ||         |.|.:.|.|.|....:.|...|....:|:
 Frog   574 PT---------GVSGEGAVVLPTIHDHMNYNTYKPAHHGA 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_609615.2	LRR	59..>228	CDD:443914	49/239 (21%)
		leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	98..158	CDD:404697	16/84 (19%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		leucine-rich repeat	148..171	CDD:275380	8/50 (16%)
		leucine-rich repeat	172..195	CDD:275380	6/41 (15%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		LRRCT	228..277	CDD:214507	16/58 (28%)
		IG_like	294..390	CDD:214653	21/104 (20%)
		Ig strand B	296..300	CDD:409353	1/4 (25%)
		Ig strand C	309..323	CDD:409353	1/13 (8%)
		Ig strand E	356..360	CDD:409353	1/3 (33%)
		Ig strand F	370..375	CDD:409353	4/4 (100%)
		Ig strand G	383..386	CDD:409353	0/2 (0%)
lrrc4	XP_002939414.1	LRRNT	40..71	CDD:214470	9/28 (32%)
		LRR	<69..>295	CDD:443914	45/227 (20%)
		leucine-rich repeat	71..94	CDD:275380	7/24 (29%)
		leucine-rich repeat	95..118	CDD:275380	4/22 (18%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		leucine-rich repeat	143..166	CDD:275380	3/22 (14%)
		leucine-rich repeat	167..191	CDD:275380	3/23 (13%)
		leucine-rich repeat	192..213	CDD:275380	4/20 (20%)
		leucine-rich repeat	214..237	CDD:275380	5/22 (23%)
		leucine-rich repeat	238..261	CDD:275380	5/22 (23%)
		leucine-rich repeat	262..283	CDD:275380	3/20 (15%)
		LRRCT	294..345	CDD:214507	16/58 (28%)
		IG_like	353..435	CDD:214653	23/114 (20%)
		Ig strand B	364..368	CDD:409353	1/3 (33%)
		Ig strand C	376..379	CDD:409353	1/27 (4%)
		Ig strand E	402..405	CDD:409353	0/2 (0%)
		Ig strand F	415..420	CDD:409353	4/4 (100%)
		Ig strand G	428..431	CDD:409353	0/4 (0%)