Protein Alignment kek4 and lrrn1

DIOPT Version :10

• Sequence 1: NP_609615.2
• Gene: kek4 / 34718
• FlyBaseID: FBgn0032484
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_002938357.1
• Gene: lrrn1 / 100492182
• XenbaseID: XB-GENE-18030784
• Length: 718
• Species: Xenopus tropicalis
• Alignment Length: 743
• Identity: 150/743 - (20%)
• Similarity: 235/743 - (31%)
• Gaps: 285/743 - (38%)

  Fly    45 CHCK---WNSGKK------TADCRNLSLSGVPEYLSPEVQV-----------------------L 77
            |.|:   |.:.:.      |.||.:|.|:.:|..||.:.||                       |
 Frog    37 CVCEIRPWFTPQSTYREATTVDCNDLRLTKIPANLSLDTQVLLLQSNNIGKTNGELQRLFNLTEL 101

  Fly    78 DLSHNHI----------------FYLEENA------FLTTHLQNLQKLLIRNGTLKYLNQRSFTQ 120
            |||.|:.                .:||||.      :....|.|||:|.|.:..|..::..:|:.
 Frog   102 DLSQNNFTSIQDVGLSNLSQLTTLHLEENQIFEMTDYCLQDLINLQELYINHNQLNSISPSAFSG 166

  Fly   121 LQILIELDLSNNLL-------VDLLPNV-----------------FDCLSKVRAIF--------- 152
            |:.|:.|.|::|.|       .:..||:                 |..|..:|::.
 Frog   167 LRNLLRLHLNSNKLRIIDSRWFESTPNLEILMIGENPVIGILDFNFQPLVNLRSLVLAGMYLSDI 231

  Fly   153 ---------------------------------------LNGNLLQALRHGVFR----------- 167
                                                   ||.|.::.::.|.|:
 Frog   232 PGNALLGLDNLESLSFYDNKLSKVPQLALQKVPNLKFLDLNKNPIRKIQEGDFKNMLKLKELGIN 296

  Fly   168 --------------NLKYLHKIELKRN-RLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDL 217
                          ||..|.|:|...| :|..|...||..||.|..:.|:||.|..:...:.:.|
 Frog   297 NMAELVSVDRNALENLPELTKLEATNNPKLSYIHRSAFRNVPTLESLMLNNNALNSVYRGTVESL 361

  Fly   218 TKLTALSLVENPWNCTCDLQMFRDFVIGMN----LYTPPTS--CHYPLQLRGRLWIEDQP--EAF 274
            ..|..:|:..||..|.|.|..     :|.|    .:..|.|  |..|.:.||      ||  ||.
 Frog   362 PNLREISIHSNPLRCDCVLHW-----MGSNQTSIRFMEPLSMFCALPPEYRG------QPVKEAL 415

  Fly   275 A-------CKPKI---VYPT-LSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKS 328
            |       |.|.|   .:|: ||..|..:   |:|.||....|...|.|
 Frog   416 AQDPAGEQCLPMISQDTFPSHLSLDIGMT---VSLDCRAMAEPEPEIYW---------------- 461

  Fly   329 LQKQRIYIELLREDESKIRKFGHDVFVSRLT------------IVNARKSDEGVYTCLAENPGGK 381
                             :...||.|....|:            |.|.:..|.|.|||:|:|..|.
 Frog   462 -----------------VTPLGHKVTTETLSDKYHLSGEGSLQIFNVQVEDSGRYTCVAQNSEGA 509

  Fly   382 D----SVHISVVVQKDMERISL----IDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQF-- 436
            |    ::.::..:....:.:.|    .:|:...:...::...|:.::.:|..|..|......:
 Frog   510 DTKVATLRVNGTLLDGTQALRLYVQQAESSSVLVSWKVSSSVLASNLKWSSATMKIDNPHITYTA 574

  Fly   437 ------HPGQHTYLQPTSLPVQSPGSEEATAISALSSGVIRESKIVLDPLSAIN-EPSNKNYTLF 494
                  |....|:|||.:      ..|....:|.|.....|         :.|| .....:|:|.
 Frog   575 RVPADVHEYNLTHLQPAT------EYEVCLTVSGLHQQAQR---------ACINVTTKGTSYSLT 624

  Fly   495 KTSNSNGS-------------EYMHTRNYKDVRLNSNTYTENLDNQAESISS-RNRELYSNI--- 542
            .|.....:             .:.....|...|.....|..:|....:..|| ...|||..:
 Frog   625 VTDQETSAALAAVMGSLFALISFASVSVYAAKRFQRKNYRHSLKKYMQKTSSIPLNELYPPLISL 689

  Fly   543 -AGDREKEELKQKDELDKDSRQSSLQST 569
             .||.|||:     |...:::.|.:.:|
 Frog   690 WEGDSEKEK-----EGTAEAKASQVDTT 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_609615.2	LRR	59..>228	CDD:443914	60/311 (19%)
		leucine-rich repeat	75..99	CDD:275380	12/68 (18%)
		LRR_8	98..158	CDD:404697	21/131 (16%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	9/46 (20%)
		leucine-rich repeat	148..171	CDD:275380	8/95 (8%)
		leucine-rich repeat	172..195	CDD:275380	9/23 (39%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		LRRCT	228..277	CDD:214507	18/63 (29%)
		IG_like	294..390	CDD:214653	22/111 (20%)
		Ig strand B	296..300	CDD:409353	2/3 (67%)
		Ig strand C	309..323	CDD:409353	2/13 (15%)
		Ig strand E	356..360	CDD:409353	1/15 (7%)
		Ig strand F	370..375	CDD:409353	3/4 (75%)
		Ig strand G	383..386	CDD:409353	0/2 (0%)
lrrn1	XP_002938357.1	LRRNT	33..76	CDD:214470	11/38 (29%)
		leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		LRR	<76..>323	CDD:443914	40/246 (16%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		leucine-rich repeat	122..145	CDD:275380	5/22 (23%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		leucine-rich repeat	194..217	CDD:275380	2/22 (9%)
		leucine-rich repeat	218..241	CDD:275380	1/22 (5%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		leucine-rich repeat	266..289	CDD:275380	5/22 (23%)
		leucine-rich repeat	290..314	CDD:275380	2/23 (9%)
		LRR_8	313..374	CDD:404697	19/60 (32%)
		leucine-rich repeat	315..336	CDD:275380	8/20 (40%)
		leucine-rich repeat	340..363	CDD:275378	6/22 (27%)
		leucine-rich repeat	364..376	CDD:275378	4/11 (36%)
		LRRCT	372..418	CDD:214507	18/56 (32%)
		I-set	431..518	CDD:400151	26/122 (21%)
		Ig strand B	445..449	CDD:409353	2/3 (67%)
		Ig strand C	458..467	CDD:409353	2/41 (5%)
		Ig strand E	484..488	CDD:409353	0/3 (0%)
		Ig strand F	498..503	CDD:409353	3/4 (75%)
		FN3	538..602	CDD:473895	11/69 (16%)