DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and lingo2

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_004910881.1	Gene:	lingo2 / 100490134	XenbaseID:	XB-GENE-922286	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	619	Identity:	122/619 - (19%)
Similarity:	191/619 - (30%)	Gaps:	241/619 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HLSLFLFKIYCLA---LIFRSASADWLLDC-GNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQV 76
            |.:...:.|.||.   |:|..::    ..| ..|.|  ::..|:..|....|..:||.:..|.::
Frog     7 HTATPCWHILCLVAMLLVFMGSA----FGCPAKCEC--SAQNKSVSCHRRRLVTIPEGIPIETKI 65

  Fly    77 LDLSHNH------------------------IFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRS 117
            ||||.|.                        |..:|..||  ..|.||:.|.::...||.:....
Frog    66 LDLSKNKLKSVNPVDFVSYPLLEDIDLSDNIISNVEPGAF--NSLFNLRSLSLKGNRLKLVPLGV 128

  Fly   118 FTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAI------------------------------- 151
            ||.|..|.:||:|.|.:|.||..:|..|..::::
Frog   129 FTGLSNLTKLDISENKIVILLDYMFQDLHSLKSLEVGDNELVYISHRAFSGLVSLEQLTLEKCNL 193

  Fly   152 --------------------FLNGNLL-------------------------------------- 158
                                :||.|:|
Frog   194 TAVPTDALSHLHNLYSLHLKYLNINVLPPFAFKRLFHLKILEISYWPLLDLVPANSLYGLNLTFL 258

  Fly   159 ------------QALRH-------------------GVFRNLKYLHKIELKRNRLVSIDAKAFVG 192
                        .||:|                   |||.:|..|.::.|...:|.:|:..||.|
Frog   259 SITNTNLSTIPYHALKHLIYLTHLNLSYNPIGIIDTGVFSDLVRLQELHLVGAQLRTIEPHAFQG 323

  Fly   193 VPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHY 257
            :..|..:.:..|.|..|...:||....|..|.:.:||..|.|.|       |.|      ...|.
Frog   324 LRFLRLLNVSQNLLETLEENAFQSPKALEVLCIDDNPLVCDCRL-------IWM------LQRHP 375

  Fly   258 PLQLRGRLWIEDQPEA-----------------FAC-KPKIVYPTLSTSINTSKENVTLICRVHG 304
            .|...|:..:...|::                 |.| ||||....:........:.|.:.|...|
Frog   376 MLHFGGQQPMCSSPDSLKESSYKVLDAAVLSFYFTCKKPKIRDREMLQVHVDEGQRVQMNCNADG 440

  Fly   305 SPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEG 369
            .|..:|:|                :..:|..:.|.....:.:...|      .|.|..|:..|.|
Frog   441 DPQPMISW----------------VTPRRRTVSLKSNGRTTVLGNG------TLEIRYAQIQDTG 483

  Fly   370 VYTCLAENPGGKDSVHISVVVQ----------------KDMERISLIDSN--------FFAIVCL 410
            .|.|:|.|..|.|:...|:.|:                .::...|...:|        ...|:..
Frog   484 TYICVASNAAGNDTFSASLTVKGFVPDRSYTNMTPMFITELNETSTNGTNANMTFNLDLKTILVS 548

  Fly   411 IAMG---FLSMSILFSLVTCLIFKRFKQFHPGQH 441
            .|||   ||.: :||..:...::.|.|    |:|
Frog   549 TAMGCFTFLGV-VLFCFLLLFVWSRGK----GKH 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	10/47 (21%)
		LRR_8	99..158	CDD:290566	21/109 (19%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_8	146..206	CDD:290566	20/179 (11%)
		leucine-rich repeat	148..171	CDD:275380	11/142 (8%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	13/66 (20%)
		IG_like	294..390	CDD:214653	21/95 (22%)
		Ig	296..387	CDD:143165	20/90 (22%)
lingo2	XP_004910881.1	LRRNT	31..64	CDD:214470	9/34 (26%)
		leucine-rich repeat	43..61	CDD:275380	5/17 (29%)
		leucine-rich repeat	63..86	CDD:275380	5/22 (23%)
		internalin_A	<66..>285	CDD:380193	35/220 (16%)
		leucine-rich repeat	87..110	CDD:275380	5/24 (21%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		leucine-rich repeat	135..158	CDD:275380	10/22 (45%)
		leucine-rich repeat	159..182	CDD:275380	0/22 (0%)
		leucine-rich repeat	183..206	CDD:275380	0/22 (0%)
		leucine-rich repeat	207..254	CDD:275380	4/46 (9%)
		leucine-rich repeat	255..278	CDD:275380	3/22 (14%)
		LRR_8	279..337	CDD:338972	13/57 (23%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..347	CDD:275380	5/19 (26%)
		TPKR_C2	359..402	CDD:387596	11/55 (20%)
		Ig	429..504	CDD:386229	21/96 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11593
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000