DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and XB5838993

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_002934278.1	Gene:	XB5838993 / 100488097	XenbaseID:	XB-GENE-5838994	Length:	660	Species:	Xenopus tropicalis

Alignment Length:	690	Identity:	147/690 - (21%)
Similarity:	218/690 - (31%)	Gaps:	265/690 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLALIFRSASADWLL-------DC-GNCHCKWNSGKKTADCRNLSLSGVPE-------------- 68
            ||.|:....:.|.|:       .| .||.|.  ..::...|.|.||:.||.
Frog    35 CLHLLILLLAFDNLVSTIPATTQCPENCTCL--PLQQHVLCGNASLTSVPSNVPNNTVELHLQNN 97

  Fly    69 -------------------YLS--------PE-------VQVLDLSHNHIFYLEENAF------L 93
                               |||        ||       ::.|.|..||:..|:|..|      :
Frog    98 LFSELHDSFLQDLPELRGLYLSNCEIDTIKPEAFQKVTSIKYLHLDRNHLGDLQEGTFRNLSSLI 162

  Fly    94 TTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLL 158
            ..||::.|...||.|.        |..|:.|..|.||||||.:|.....:.|:::|.:.|..|:|
Frog   163 YLHLESNQITSIREGL--------FAPLEKLSALYLSNNLLQELTDGSLNGLTQLRWLDLGFNML 219

  Fly   159 QALRHGVFRNLKYLHKIELKRNRLVSIDA--KAFVGVPLL----------------------SQI 199
            ..:.:..|..:..|.|:.|:||.|.||.:  :...|:.:|                      :::
Frog   220 SKISNQSFTAIANLRKLNLERNNLTSIPSAIRRRTGLQMLRLSGNSIKKLSSSSFGRSLRFITEL 284

  Fly   200 YLDNNELTKLRVESFQDLTKL---------------------TALSLVENPWNCTCDLQMFRDFV 243
            |||:..|.|:...:|..|..|                     |.:.|..|||.|.|.|
Frog   285 YLDSLRLEKVTSMTFSKLRMLKVLDLSNNSLQSLSVYNVKIFTKIYLTGNPWRCDCSL------- 342

  Fly   244 IGMNLYTPPTS---------CHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTSINTSKENVTLI 299
            ||::.....|.         |..|..|:|:..|........|      |.....|:.:....:|:
Frog   343 IGLHTRLQQTKNLDAEQQAHCDAPKALKGQSLINVNLLKLTC------PATGEDISVTASTPSLL 401

  Fly   300 CRVHGS---PNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIV 361
                ||   .||.|     ..|.|: .||.....|            :..:...|.      |..
Frog   402 ----GSSQFANTSI-----RSVVET-MKPTTHAYK------------TSPQAMSHS------TAG 438

  Fly   362 NARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLI-------DSNFFAI------------ 407
            |.:...|....|||:        |||.||.:.:|:.||.       |...|.|
Frog   439 NNKIEAEEQDPCLAK--------HISNVVVRPVEKESLDVSWSIHGDYKQFEIRYSTEEEKSSLN 495

  Fly   408 --------------------VCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQ---------HTY 443
                                ||::...       ..:|.|.:.|. :|...||         |.|
Frog   496 IIGDLPNIRLYHLNPGSSYRVCIVPQN-------VDIVKCQLAKT-RQCADGQTADVPEQAYHVY 552

  Fly   444 LQPTSL-PVQSPGSEEA----TAISALSSGVIRESKIVLDPLSAINEPSNKNYTLFKTSNSNGSE 503
            ..|.|. |:.:.|....    .|.:..:..::|..||..           :.|  :....:.||.
Frog   553 SPPKSTSPIVTVGVSVGLIVLVAATIFAVYMLRSHKIQF-----------QRY--YNEDGAEGSR 604

  Fly   504 YMHTRNYKDVRLNSNTYTENLDNQAESISSRNRELYSNIA 543
            ...|..||    ....| ||:|:        :|.:|...|
Frog   605 KQETDPYK----WDGVY-ENIDD--------DRHVYVTAA 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	9/29 (31%)
		LRR_8	99..158	CDD:290566	19/58 (33%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_8	146..206	CDD:290566	18/83 (22%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	9/24 (38%)
		leucine-rich repeat	196..219	CDD:275380	8/44 (18%)
		TPKR_C2	228..277	CDD:301599	14/57 (25%)
		IG_like	294..390	CDD:214653	21/98 (21%)
		Ig	296..387	CDD:143165	19/93 (20%)
XB5838993	XP_002934278.1	LRRNT	57..91	CDD:214470	10/35 (29%)
		LRR_8	91..147	CDD:338972	8/55 (15%)
		leucine-rich repeat	91..112	CDD:275380	0/20 (0%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_8	136..195	CDD:338972	21/66 (32%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		LRR	138..437	CDD:227223	79/347 (23%)
		leucine-rich repeat	161..184	CDD:275380	8/30 (27%)
		leucine-rich repeat	185..208	CDD:275380	10/22 (45%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..255	CDD:275380	8/21 (38%)
		leucine-rich repeat	256..280	CDD:275380	1/23 (4%)
		leucine-rich repeat	281..304	CDD:275380	7/22 (32%)
		fn3	456..524	CDD:365830	11/74 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910