DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and lrfn1.1

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_002940407.1	Gene:	lrfn1.1 / 100487064	XenbaseID:	XB-GENE-6045969	Length:	742	Species:	Xenopus tropicalis

Alignment Length:	642	Identity:	133/642 - (20%)
Similarity:	215/642 - (33%)	Gaps:	192/642 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KIYCLALIFRSASADWLLDC-GNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFY 86
            |:.||.::......:....| |.|.|:.||...|..|....|..||..:......|.|:.|
Frog     3 KLLCLLVMGALGYVEATQHCPGRCLCQSNSPTLTMLCAKTGLLFVPPAIDRRTVELRLTDN---- 63

  Fly    87 LEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAI 151
                 |:|         :||        ::.|..:..|:.|.||.|.:..::|..|..|..:||:
Frog    64 -----FIT---------IIR--------RKDFANMTNLVHLTLSRNTISQIVPLAFFDLRSLRAL 106

  Fly   152 FLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFV-----------------GVPL---- 195
            .:|.|.|..|||..||.|..|..:.|..|::..|...|||                 .:|.
Frog   107 HMNSNRLSLLRHEHFRGLGNLRHLILGNNQISFIQPGAFVEFLSTVEDLDLSYNNLEELPWEDIG 171

  Fly   196 ----LSQIYLDNNELTKLRVESFQDLTKLT----------------------------------- 221
                |:.:.||:|.:..:...:|..|.||.
Frog   172 QMVNLNTLTLDHNLIDHIAEGTFTMLHKLVRLDMTSNQLHKLPPDNLFLRSQVLANARGSSPSSL 236

  Fly   222 ALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLS 286
            |:|...||.:|.|:|...|......:|.|    |..|.||..:.:...|.|.|.|.|.::
Frog   237 AISFGGNPLHCNCELLWLRRLTREDDLET----CASPEQLTDKYFWSIQEEEFICDPPLI----- 292

  Fly   287 TSINTSK------ENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESK 345
            |....||      ::|:|.|:..|.|...|.|      .....|.:.:..:      |:..|...
Frog   293 TRHYASKPFVMEGQSVSLKCKAVGDPEPSIHW------IAPDGKLIHNTTR------LVAHDNGS 345

  Fly   346 IRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLIDSNFFAIVCL 410
            :     |:.::.|       .|.|.:||:|.|..|:.:..:.:.:..    :.|:.:|...|
Frog   346 L-----DIMITTL-------KDSGSFTCIASNAAGEATAPVELAIVP----LPLLVNNTAHI--- 391

  Fly   411 IAMGFLSMSILFSLVTCLIFKRFKQFHPGQHTYLQPTSLPVQSPGSEEATAISALSSGVIRESKI 475
                                   |:..||.......|     .||..:..:        ..:.:|
Frog   392 -----------------------KEQDPGSSDITTST-----KPGFNDTKS--------HHDRRI 420

  Fly   476 VLDPLSAINEPSNKNYTLFKTSNSNGSEYMHTRNYKDVRLNSNTYTENLDNQA--ESISSRNRE- 537
            |:|.|.               |.|...::...|:...:|:....|..:||:..  ..|...||.
Frog   421 VVDKLK---------------STSVVIQWPSERHIPGIRMYQIQYNSSLDDSLVYRMIPPSNRSF 470

  Fly   538 LYSNIAGDREKEELKQKDELDKDSRQSSLQSTGCSR-----KKGQIDELQPDLLPST 589
            |.:::|..||.:........|..:..::.:..||.:     :.||...|....|..|
Frog   471 LVNDLAPGREYDLCVLAVYDDGMTALTATRVVGCVQFSTRDESGQCQPLHTQFLGGT 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	5/23 (22%)
		LRR_8	99..158	CDD:290566	15/58 (26%)
		leucine-rich repeat	100..123	CDD:275380	3/22 (14%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR_8	146..206	CDD:290566	23/84 (27%)
		leucine-rich repeat	148..171	CDD:275380	11/22 (50%)
		leucine-rich repeat	172..195	CDD:275380	7/39 (18%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	15/48 (31%)
		IG_like	294..390	CDD:214653	19/95 (20%)
		Ig	296..387	CDD:143165	19/90 (21%)
lrfn1.1	XP_002940407.1	leucine-rich repeat	55..78	CDD:275380	8/48 (17%)
		PPP1R42	58..208	CDD:411060	43/175 (25%)
		leucine-rich repeat	79..102	CDD:275380	8/22 (36%)
		leucine-rich repeat	103..126	CDD:275380	11/22 (50%)
		leucine-rich repeat	127..151	CDD:275380	7/23 (30%)
		leucine-rich repeat	152..175	CDD:275380	1/22 (5%)
		leucine-rich repeat	176..199	CDD:275380	6/22 (27%)
		leucine-rich repeat	200..218	CDD:275380	1/17 (6%)
		LRRCT	243..288	CDD:214507	15/48 (31%)
		Ig	290..378	CDD:416386	22/116 (19%)
		Ig strand A	290..293	CDD:409353	0/7 (0%)
		Ig strand A'	298..301	CDD:409353	2/2 (100%)
		Ig strand B	307..315	CDD:409353	3/7 (43%)
		Ig strand C	321..326	CDD:409353	2/10 (20%)
		Ig strand C'	329..331	CDD:409353	0/1 (0%)
		Ig strand D	337..341	CDD:409353	1/9 (11%)
		Ig strand E	344..348	CDD:409353	0/8 (0%)
		Ig strand F	358..365	CDD:409353	3/6 (50%)
		Ig strand G	368..378	CDD:409353	1/9 (11%)
		fn3	418..492	CDD:394996	18/88 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49155
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910