DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and si:ch211-180f4.1

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001373634.1	Gene:	si:ch211-180f4.1 / 100144405	ZFINID:	ZDB-GENE-080327-27	Length:	744	Species:	Danio rerio

Alignment Length:	563	Identity:	122/563 - (21%)
Similarity:	184/563 - (32%)	Gaps:	220/563 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SISLKHLSLFLFKIYC-LALIFRSASADWLLDCGNCHCK---WNSGK------KTADCRNLSLSG 65
            |.||..:.|.|....| ||:.|..|         .|.|:   |.:.:      ||.||..|.||.
Zfish     7 STSLLTVCLVLAVCRCSLAVPFCPA---------QCVCETRPWYTPQSVYHQAKTVDCNELHLSR 62

  Fly    66 VPEYLSPEVQV-----------------------LDLSHNHI----------------FYLEENA 91
            :|..:|.:.||                       ||||.||.                .|||||.
Zfish    63 IPWNISVDTQVLLLQSNNISRGTSQLQSLVNLTELDLSQNHFTQIHDVGLNNLTQLVTLYLEENQ 127

  Fly    92 ------FLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLV-------DLLPNV-- 141
                  .....|.:|::|.|.:..:..:...:|:.|..|:.|.|::|.||       :.|||:
Zfish   128 IKELPDMCLKDLVSLEELYINHNQISSIGPNAFSGLGNLLRLHLNSNKLVAIDSHWFESLPNLEI 192

  Fly   142 ---------------FDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFV 191
                           |..|:|:.::.|.|..|:.:..|.|:.|:||..:....|:|.::..||..
Zfish   193 LMIGENPILGLQDMNFHPLTKLHSLVLAGMGLREIPEGAFQGLEYLESLSFFDNKLTAVPKKALR 257

  Fly   192 GVPLLSQIYLDNNELTKLRVESFQDLTKLTALSL--------VE--------------------- 227
            .:|.|..:.|:.|.:.:::...|||...|..|||        ||
Zfish   258 VLPSLKFLDLNKNPIVRIQEGDFQDFPHLEELSLNNMEELVAVERGSFSNLPQMAKLELYNNPHL 322

  Fly   228 ---------------------------------------------NPWNCTCDLQMFRDFVIGMN 247
                                                         ||..|.|           :|
Zfish   323 FFIDRAAFLKMRGLRTLLIHNNDLTLLPHEIVSAFPNLDEISLHSNPLRCDC-----------LN 376

  Fly   248 LYTPP--------------TSCHYPLQLRGRLWIEDQPEAF------ACKPKIVYPTLSTSIN-T 291
            .:.|.              |.|..|..|.|:. ::|...|.      .|.|.|........:| |
Zfish   377 NWGPVLGNQSSLKVLEPQITLCASPQHLVGQA-LQDVVSASWNGASNTCLPLISQHAFPPQLNVT 440

  Fly   292 SKENVTLICRVHGSPNTVIAW------DYTNQ-VYESRSKPVKSLQKQRIYIELLREDESKIRKF 349
            ..:.:||.|.....|.....|      ..|:: |..|.::...:.:|.|:      :|:
Zfish   441 LGQLLTLDCWAVADPAPQFYWVTPTGDKVTSEAVSPSSNEGGGTPKKHRM------QDQ------ 493

  Fly   350 GHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQK 392
                  ..|.|.:....|.|:|||:|.|..|.|:..:||.|.|
Zfish   494 ------GALEIPHIEPEDTGLYTCVAWNAEGADTRSVSVYVDK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	14/68 (21%)
		LRR_8	99..158	CDD:290566	19/82 (23%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	11/46 (24%)
		LRR_8	146..206	CDD:290566	17/59 (29%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	13/68 (19%)
		IG_like	294..390	CDD:214653	24/102 (24%)
		Ig	296..387	CDD:143165	22/97 (23%)
si:ch211-180f4.1	NP_001373634.1	leucine-rich repeat	51..70	CDD:275380	9/18 (50%)
		PPP1R42	55..266	CDD:411060	51/210 (24%)
		leucine-rich repeat	71..93	CDD:275380	2/21 (10%)
		leucine-rich repeat	94..117	CDD:275380	6/22 (27%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		leucine-rich repeat	142..165	CDD:275380	5/22 (23%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		leucine-rich repeat	190..213	CDD:275380	2/22 (9%)
		leucine-rich repeat	214..237	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	5/22 (23%)
		LRR_8	260..320	CDD:404697	13/59 (22%)
		leucine-rich repeat	262..285	CDD:275380	6/22 (27%)
		leucine-rich repeat	286..310	CDD:275380	6/23 (26%)
		leucine-rich repeat	311..330	CDD:275380	0/18 (0%)
		leucine-rich repeat	336..359	CDD:275378	0/22 (0%)
		PCC	341..>412	CDD:188093	11/82 (13%)
		leucine-rich repeat	360..372	CDD:275378	2/11 (18%)
		IG	434..528	CDD:214652	26/111 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910