DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	635	Identity:	135/635 - (21%)
Similarity:	224/635 - (35%)	Gaps:	225/635 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCK---WNSGK------KTADCRNLSLSGVPEYLSPEVQV-----------------------L 77
            |.|:   |.:.:      ||.||.:|.|:.:||.||.::||                       |
Frog    42 CVCETRPWFTPQSVYHEAKTVDCNDLLLTHIPENLSTDIQVLLLQSNKISHLTWELQELSNLTEL 106

  Fly    78 DLSHNHI----------------FYLEENA------FLTTHLQNLQKLLIRNGTLKYLNQRSFTQ 120
            |||.||.                .|||||.      :....|.:|::|.|.:..:.|:..|:|:.
Frog   107 DLSQNHFQSIDDLGVSNLSQLITLYLEENQLRELPDYSLKDLGSLEELYINHNQISYIGPRAFSG 171

  Fly   121 LQILIELDLSNNLL-------VDLLPNV-----------------FDCLSKVRAIFLNGNLLQAL 161
            |..|:.|.|:.|.|       .:.|||:                 |..|.::.::.|.|..|:.:
Frog   172 LGRLLRLHLNANRLEIIDPRWFEDLPNLEILMVGENPVTALQSLNFQPLGRLHSLVLAGMELEHI 236

  Fly   162 RHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNN---------------------- 204
            ....|:.|.||..:....|||..:..:|...:.||..:.|:.|
Frog   237 PENAFQGLDYLESLSFFDNRLTEVPKEALKNLKLLKFLDLNKNPIPEIRGGDFTGMEHLEELSLN 301

  Fly   205 ---ELTKLRVESFQDLTKLTALSLVENPWNCTCD-------------------------LQMFRD 241
               ||.::..|:||||.:|..|.:..||.....|                         |::|:.
Frog   302 SMEELERVEAEAFQDLPELIKLEMCNNPRLSYLDPEAFSSNLGALKTLLLNNNRLAMVPLKIFQA 366

  Fly   242 F--VIGMNLYTPP----------------------TSCHYPLQLRGRLWIEDQPEAF--ACKPKI 280
            .  ::.::||:.|                      |.|..|..:.|.|:.|.|.:|:  .|.|.|
Frog   367 LPGLLEISLYSNPIRCDCQNCWKGLSKLRLIEAQATLCINPPLVSGHLFQEIQGQAWLNRCPPLI 431

  Fly   281 VYPTLSTSINTSK-ENVTLICRVHGSPNTVIAW--DYTNQVYESRSKPVKSLQKQRIYIELLRED 342
            ....:......:: :.|.|.|:..|.|...|.|  .:..:|..:..:
Frog   432 DTHLIPPQFQIARHQPVKLSCQASGHPKPEIYWMTPHGERVTGTNGR------------------ 478

  Fly   343 ESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKD--SVHISVVVQKDMERISL------ 399
             .||...|      .|.|.:|.:.|.|.|||...|..|.|  ||.:|:...::.|.:||
Frog   479 -VKINAGG------SLEITDAVEEDSGSYTCQMWNSDGTDSKSVFVSINRTQEPEAMSLLMVTKK 536

  Fly   400 IDSNFFAIVCLIAMGF-LSMSIL----FSLVTCLIFKRFKQFHPGQHTYLQPTSLPVQ------- 452
            :.|||..:...:..|. :|.::|    :|..|..|       |....:|.....|.||
Frog   537 VHSNFAVVEWKMLSGSGVSPNVLVPFQWSSATMRI-------HNPHISYTAKVPLEVQEYNLTHL 594

  Fly   453 SPGSEEATAISALSSGVIRESKIVLDPLSAINEPSNKNYTLFKTSNSNGS 502
            .|.::....::                :|::::||.::.....|.:::.|
Frog   595 QPSTKYEVCLT----------------VSSVSQPSQQSCLNITTRDASFS 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	14/68 (21%)
		LRR_8	99..158	CDD:290566	19/82 (23%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	10/46 (22%)
		LRR_8	146..206	CDD:290566	15/84 (18%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	10/47 (21%)
		TPKR_C2	228..277	CDD:301599	16/99 (16%)
		IG_like	294..390	CDD:214653	25/99 (25%)
		Ig	296..387	CDD:143165	24/94 (26%)
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	51/209 (24%)
		leucine-rich repeat	60..79	CDD:275380	10/18 (56%)
		leucine-rich repeat	80..102	CDD:275380	2/21 (10%)
		LRR_8	101..161	CDD:316378	15/59 (25%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		leucine-rich repeat	127..150	CDD:275380	6/22 (27%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		leucine-rich repeat	175..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	2/22 (9%)
		leucine-rich repeat	223..246	CDD:275380	5/22 (23%)
		leucine-rich repeat	247..294	CDD:275380	9/46 (20%)
		LRR_8	294..356	CDD:316378	12/61 (20%)
		leucine-rich repeat	295..319	CDD:275380	7/23 (30%)
		leucine-rich repeat	320..345	CDD:275380	5/24 (21%)
		leucine-rich repeat	346..367	CDD:275380	2/20 (10%)
		PCC	351..>412	CDD:188093	8/60 (13%)
		leucine-rich repeat	370..382	CDD:275378	3/11 (27%)
		Ig	448..515	CDD:319273	22/91 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910