DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and lingo4a

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001076447.1	Gene:	lingo4a / 100005227	ZFINID:	ZDB-GENE-060503-275	Length:	618	Species:	Danio rerio

Alignment Length:	600	Identity:	126/600 - (21%)
Similarity:	191/600 - (31%)	Gaps:	221/600 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SADW--------------LLDCGNC--HCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNH 83
            :|||              :...|.|  .|..:......||.:..||.|||.:....|||:|::||
Zfish    18 AADWRRLYWWVVLQWVVGVATSGPCAQRCDCSPKLPLVDCSSQQLSAVPEGVPDATQVLNLTYNH 82

  Fly    84 IFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKV 148
            :..|....|.:  |:.|::|.:....|..:...:|..||.||.|.||.|.|..:....|..|..|
Zfish    83 LKTLSSRQFFS--LRQLRELDLSANMLTVIEVEAFVGLQNLITLRLSRNRLKIIPVGAFSGLPNV 145

  Fly   149 RAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVES 213
            :.:.::.|.:..|...:|..:..|.|:|...|.||.|..:||.|:|.|.::.|:...||.:..|:
Zfish   146 QFLDISENEILVLLDDMFGEMPSLQKLEASENDLVFISNRAFSGLPNLLELRLERCNLTTVPSEA 210

  Fly   214 FQDLT-----KLTALSLVENPWNCTCDLQMFRDF---------------VIGMNL---------- 248
            |..||     :...|.|...|.|....||..:|.               :||:||
Zfish   211 FSRLTGLQHLRFCRLGLTALPNNSFRQLQRLQDLHVSRCPWLHTLAVNSLIGLNLTSLTLSHCNL 275

  Fly   249 --------------------YTPPT---------------------------------------- 253
                                |.|.|
Zfish   276 SAVPYAPLHHLVYLRYLDLSYNPITTVLSGLLGDLLRLQELHLVSTGLLHVESGAFRNLAFFRLL 340

  Fly   254 ------------------------------------------------------SCHYPLQLRGR 264
                                                                  ||..|:|::||
Zfish   341 NVSDNRLVTLEESAFHAVGSLEVLRLDGNPLACDCRLLWVMRRRLRLRFAGHAPSCVSPVQVQGR 405

  Fly   265 LWIEDQPEA-----FACKPKIVYPTLSTSINTSK-ENVTLICRVHGSPNTVIAWDYTNQVYESRS 323
            :: :|..|:     |.|:...:.......:.:.: ..|...|...|.|...|.|          .
Zfish   406 MF-QDFAESEVARTFTCRQARILTRKPQDVRSDEGHTVLFFCAADGDPAPSIIW----------L 459

  Fly   324 KPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISV 388
            .|.:|:......|.:|.....::|              .|:..|.|.|.|:|.|..|.||:.:|:
Zfish   460 NPKRSVLTASGRIRVLPNGTLEVR--------------YAQVQDSGYYLCIASNAAGNDSISVSL 510

  Fly   389 VVQ------KDMERISLIDSNFFA------------------IVCLIAMGFLSMSILFSLVTCLI 429
            .|:      ::......:|...||                  :|..:.||||  |.|.|:..|.|
Zfish   511 RVRGFPASSRNRSGSFFLDGWSFASGQTAVNGSQPFPFDVKTLVIAVTMGFL--SFLSSVALCFI 573

  Fly   430 FKRFKQFHPGQ--HT 442
            |..|.....||  ||
Zfish   574 FMFFWSQSKGQIKHT 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	9/23 (39%)
		LRR_8	99..158	CDD:290566	17/58 (29%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_8	146..206	CDD:290566	17/59 (29%)
		leucine-rich repeat	148..171	CDD:275380	4/22 (18%)
		leucine-rich repeat	172..195	CDD:275380	10/22 (45%)
		leucine-rich repeat	196..219	CDD:275380	8/27 (30%)
		TPKR_C2	228..277	CDD:301599	21/192 (11%)
		IG_like	294..390	CDD:214653	22/95 (23%)
		Ig	296..387	CDD:143165	21/90 (23%)
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	9/28 (32%)
		leucine-rich repeat	52..72	CDD:275380	7/19 (37%)
		leucine-rich repeat	73..96	CDD:275380	9/24 (38%)
		LRR_RI	88..380	CDD:238064	54/293 (18%)
		LRR_8	95..155	CDD:290566	17/59 (29%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		leucine-rich repeat	145..168	CDD:275380	4/22 (18%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		LRR_8	191..250	CDD:290566	16/58 (28%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		leucine-rich repeat	217..240	CDD:275380	5/22 (23%)
		leucine-rich repeat	241..288	CDD:275380	5/46 (11%)
		LRR_8	264..323	CDD:290566	5/58 (9%)
		leucine-rich repeat	289..310	CDD:275380	3/20 (15%)
		LRR_8	312..371	CDD:290566	0/58 (0%)
		leucine-rich repeat	313..336	CDD:275380	0/22 (0%)
		leucine-rich repeat	337..356	CDD:275380	0/18 (0%)
		I-set	428..512	CDD:254352	22/107 (21%)
		Ig	439..512	CDD:299845	22/96 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910