DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pect and Pcyt2

DIOPT Version :9

Sequence 1:	NP_723789.2	Gene:	Pect / 34716	FlyBaseID:	FBgn0032482	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_077191.2	Gene:	Pcyt2 / 68671	MGIID:	1915921	Length:	404	Species:	Mus musculus

Alignment Length:	395	Identity:	240/395 - (60%)
Similarity:	291/395 - (73%)	Gaps:	15/395 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NGDTSACNGYSDKQRKDVRVWCDGCYDMVHFGHANSLRQAKALGDKVIVGIHTDEEITKHKGPPV 68
            :|..||........::.|||||||||||||:||:|.||||:|:||.:|||:||||||.|||||||
Mouse     6 HGAASAAGLKGPGDQRIVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPV 70

  Fly    69 FTEEERVKMVKGIKWVDEVVLGAPYVTTLDVLDQNNCDFCVHGDDITMTAEGVDTYHLVKSANRY 133
            ||:|||.|||:.||||||||..|||||||:.||::||||||||:|||:|.:|.|||..||.|.||
Mouse    71 FTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKHNCDFCVHGNDITLTVDGRDTYEEVKQAGRY 135

  Fly   134 KEVKRTAGVSTTDLVGRMLLLTRNHF--RQGSAEYDIEKEVSILKRQIKSHP-------GSSNMG 189
            :|.|||.|||||||||||||:|:.|.  ::.|:||. |...|..|   ..||       .|....
Mouse   136 RECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYR-EYADSFGK---PPHPTPAGDTLSSEVSS 196

  Fly   190 QDSAAKSPWTGCSQFLPTTQKIIQFSDGKSPNPGDKIVYVAGAFDLFHVGHLDFLEKAKKLG--D 252
            |....:|||||.||||.|:||||||:.||.|.||:.::||||||||||:||:|||::..||.  .
Mouse   197 QCPGGQSPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLQEVHKLAKRP 261

  Fly   253 YLIVGLHTDPVVNSYKGSNYPIMNLHERVLSVLACKFVNEVVIGAPYCVTEELLEHFKIDVVCHG 317
            |:|.|||.|..||.|||.||||||||||.||||||::|:||||||||.||.|||.|||:|:||||
Mouse   262 YVIAGLHFDQEVNRYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLNHFKVDLVCHG 326

  Fly   318 RTPIALENGKIDPYAVPKTRAIFELIDSGNEMTTERIVERIISHRLEYERRNQAKEKKEIEAFEA 382
            :|.|..:....|||..||.|.||..||||:::||:.||:|||.:|||||.|||.||.||:...||
Mouse   327 KTEIVPDRDGSDPYQEPKRRGIFYQIDSGSDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFLEA 391

  Fly   383 LQRQK 387
            .::|:
Mouse   392 TKQQE 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pect	NP_723789.2	PTZ00308	16..381	CDD:140329	234/375 (62%)
		CCT	19..165	CDD:173925	105/147 (71%)
		ECT	223..373	CDD:173924	96/151 (64%)
Pcyt2	NP_077191.2	PTZ00308	15..390	CDD:140329	234/378 (62%)
		CCT	21..163	CDD:173925	104/141 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..201		6/30 (20%)
		ECT	230..382	CDD:173924	96/151 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850756
Domainoid	1	1.000	207	1.000	Domainoid score	I2886
eggNOG	1	0.900	-	-		E1_COG0615
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2143
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1468
Isobase	1	0.950	-	0	Normalized mean entropy	S1081
OMA	1	1.010	-	-		QHG53814
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003672
OrthoInspector	1	1.000	-	-		oto95279
orthoMCL	1	0.900	-	-		OOG6_100945
Panther	1	1.100	-	-	LDO	PTHR45780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2100
SonicParanoid	1	1.000	-	-		X3035
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740