DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Edem2 and EDEM1

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_055489.1	Gene:	EDEM1 / 9695	HGNCID:	18967	Length:	657	Species:	Homo sapiens

Alignment Length:	488	Identity:	214/488 - (43%)
Similarity:	299/488 - (61%)	Gaps:	47/488 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRGVTPSRGD-----MDDILGNFSMTLV 106
            ||::|:.||.||...|:.||.:|:|.|||.|:.|:||    .|.|||     ::|:|||:|:|||
Human   127 RAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGR----GPDRGDPSNLNINDVLGNYSLTLV 187

  Fly   107 DTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVGGLLSAH-ILAEYLQKHAD-T 169
            |.||||.::|:.:||..||||||..|.||.|..|.|||..||::|.||||| |:.:..|...| |
Human   188 DALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMT 252

  Fly   170 MHWYKGELLEMSRELGYRLLPAF-NTSTGIPHARVNLRLGMKDPMLKKSRETCTACAGTILLEFA 233
            :..|..|||.|:.:|..|||||| ||.||||:.||||:.|:..   ..:.|||||.||::|:||.
Human   253 IKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPP---DTNNETCTAGAGSLLVEFG 314

  Fly   234 ALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVRRDSGVGAGIDSYYEYLFKS 298
            .||||.||..||..|..|:.|||.||...:.|:|.|:|:.:|.||.:.||:|||:||:||||.||
Human   315 ILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKS 379

  Fly   299 YVLLGDDKYLARFNRHYNAVMKYVSEG-----------PMLLDVLMHRPHAKSKNFMDSLLAFWP 352
            |:|.|:.:.|..||..|.::..|:..|           |:.::|.|......: .::|||.||:|
Human   380 YILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLMN-TWIDSLQAFFP 443

  Fly   353 GLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQ---HPLRPEFIESTYFLYRATG 414
            |||||.||::.|:..|...|.:.:.:..:||.:  ::|:....   :|||||.:||||.||:||.
Human   444 GLQVLIGDVEDAICLHAFYYAIWKRYGALPERY--NWQLQAPDVLFYPLRPELVESTYLLYQATK 506

  Fly   415 DHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQDLIIN 479
            :..||.||...|::|:::.||.||||.::.|.....||||:||.||||.|||:|||.:...:..:
Human   507 NPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSTEDRMESFFLSETCKYLYLLFDEDNPVHKS 571

  Fly   480 VDEFVFTTEAHLLPLSIAQLGNATFSFRQTDEH 512
            ...::||||.|::               ..|||
Human   572 GTRYMFTTEGHIV---------------SVDEH 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	206/458 (45%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041
EDEM1	NP_055489.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..94
EDEM1	NP_055489.1	Glyco_hydro_47	137..582	CDD:279825	205/454 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950