DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem2 and MNL1

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_012074.3	Gene:	MNL1 / 856611	SGDID:	S000001247	Length:	796	Species:	Saccharomyces cerevisiae

Alignment Length:	787	Identity:	233/787 - (29%)
Similarity:	356/787 - (45%)	Gaps:	121/787 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRGV-TPSRGDMDDILGNFSMT 104
            :.::||....::|.:::||..::.|:::.||.||:.|:||..:.|.. .|:....:||||||::|
Yeast    26 SFTSKELKAYKQEVKELFYFGFDNYLEHGYPYDEVKPISCVPKKRNFEDPTDQGTNDILGNFTIT 90

  Fly   105 LVDTLDTLVLLGDFTEFDHAVKLVIR---DVQFDSDIIVSVFETNIRMVGGLLSAHILAEYLQKH 166
            |:|:|.|:.:|.|..:|..||:||.|   |..||.|..:.|||..||::|.|||:|:.|....|.
Yeast    91 LIDSLTTIAILEDRPQFLKAVRLVERTFPDGNFDIDSTIQVFEITIRVIGSLLSSHLYATDPTKA 155

  Fly   167 ADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLG---MKDPMLKKSRETCTACAGTI 228
            ......|.|.||.:::.:..|||||:.||||:|..|.|::..   .:.|...::.....|.|..
Yeast   156 VYLGDDYDGSLLRLAQNMADRLLPAYLTSTGLPMPRRNIKRKWDVSEFPEFLETENNVAAMASP- 219

  Fly   229 LLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVRRDSGVGAGIDSYYE 293
            :.||..||.|||||.:|.....|.|..|.|| .|.||:....:..........:|:||.|||.:|
Yeast   220 MFEFTILSYLTGDPKYEKVTRYAFDKTWSLR-TGLDLLPMSFHPEKLTPYTPMTGIGASIDSLFE 283

  Fly   294 YLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFMDSLLAFWPGLQVLS 358
            |..|..:|..|.:.:..:|..|.|:...........:|:....|. ...::|||.||:.|||||:
Yeast   284 YALKGAILFDDSELMEVWNVAYEALKTNCKNDWFFANVMADTGHL-FVPWIDSLSAFFSGLQVLA 347

  Fly   359 GDLKPAVQTHEMLYQVMQMHTFIPE-------------------AFTVD--FQIHWGQHPLRPEF 402
            |||..|:..|.|..::......|||                   |..:|  ..:.|  :||||||
Yeast   348 GDLDDAIANHLMFLKMWNTFGGIPERWNFSPPEFPPLSPLERSGAVALDNILPLEW--YPLRPEF 410

  Fly   403 IESTYFLYRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLF 467
            .||||||||||.|..||.:|...||.|:|..|.:||:|...:|.||:.:|||::||||||:|||:
Yeast   411 FESTYFLYRATKDPFYLNIGVHLLKDLKQRFKSNCGFAGFQNVITGELQDRMETFVLSETLKYLY 475

  Fly   468 LLFSDPQDLIINVDEFVFTTEAH--LLPLSI-------AQLGNATFSF---------RQTDEHNV 514
            |||.:..:|..:..:.:|:||||  .||..:       |:..|:.:|.         |:....|.
Yeast   476 LLFDEENELHNSASDVIFSTEAHPMWLPQEVRSNYKRNAKFNNSVYSSHLEICQKKDREQAGENT 540

  Fly   515 LDFMRTCPSSNRLF-----PEKVRKPLRNF-----ITGSC---PRTTAGKRLSALDF----QASN 562
            |. .|....:..:|     .|:...|:.::     :.|:|   |....|.     :|    ..||
Yeast   541 LS-QRIVGFAKSIFHKGPPDEEATDPIIDYTIDTELPGTCSIKPHHVIGD-----EFWYSPMLSN 599

  Fly   563 ADHLRAVYD-MGITMVSVGD-RSQGKVRLFHSFYNAKSHEEGEMGL-----QFMQEMLELTKMQS 620
            .|.|..:.. ...|::.... .:...:.|...|||..|:.:....|     :..:.:.:|.....
Yeast   600 FDRLFEIDSRFAATLIKPSHMHNYNAIELEPGFYNRWSNPQFSTCLIPPTTEIFELLFDLPGYHQ 664

  Fly   621 INQLAQLQAVAYATDENSQDWIALMAGPSHFSPELTGDQFVE--GDVILAKPLR----------A 673
            :|.|..         ||.........|.|....|......::  ||:|.|...:          |
Yeast   665 LNPLML---------ENKTITFETFGGRSRLKIEKLQIYQIDYYGDLITASTFQDVSRKDIFSNA 720

  Fly   674 CDESLENAEEAKGKVLVAERGDCTFVSK-----ARLAQKVGAAALIVCDNVPGSSG-ETQPMFAM 732
            ||             .||.....|::.:     .|:..:.|:..:.....|..|:| ..:..|.|
Yeast   721 CD-------------AVASLYSPTYLYRVVAINGRILPRHGSVQIKKHSPVLTSNGTREEDEFKM 772

  Fly   733 SGDGKDD 739
            .|.|.:|
Yeast   773 DGIGIND 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	175/466 (38%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041	23/113 (20%)
MNL1	NP_012074.3	Glyco_hydro_47	42..502	CDD:396217	174/464 (38%)
MNL1	NP_012074.3	BRCT	<557..594	CDD:412126	7/41 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I265
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	284	1.000	Inparanoid score	I550
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	1	1.000	-	-		otm46476
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R726
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.950