DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem2 and EDEM3

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_001306889.1	Gene:	EDEM3 / 80267	HGNCID:	16787	Length:	948	Species:	Homo sapiens

Alignment Length:	756	Identity:	381/756 - (50%)
Similarity:	523/756 - (69%)	Gaps:	37/756 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AMCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRG 86
            |.|:|.|..:.|....|   ||.:|:.:|..:..:||.|||..||::||||||||||:|:||.||
Human    27 AFCLVSATSVWTAGAEP---MSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRG 88

  Fly    87 VTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVG 151
            ..|||||:||.||.||:||:|:|||||:|....||:.||:.|:|||..|:|::|||||||||::|
Human    89 QEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLG 153

  Fly   152 GLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKDPMLKK 216
            |||..|.||..|::..:.|.||..|||:|:::|||:|||||||::|:|:.|:||:.|::.|..:.
Human   154 GLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEART 218

  Fly   217 SRE--TCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVR 279
            ..|  ||||||||::||||||||.||..|||..|..|:|.||:.|.|.|:|:|..:|:|:|||||
Human   219 GTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVR 283

  Fly   280 RDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFM 344
            :|||||||||||||||.|:|||||||.:|.|||.||:|:|:|:|:.|:||||.:|:|...::.:|
Human   284 KDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWM 348

  Fly   345 DSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQHPLRPEFIESTYFL 409
            |:||||:||||||.||::||::||||||||::.|.|:|||||.||::||.||||||||.||||||
Human   349 DALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFL 413

  Fly   410 YRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQ 474
            |:||||.:||:|||..::.|.::|:|.||:||:.|||||.||||||||.|:|..|||:|||:|.:
Human   414 YKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKE 478

  Fly   475 DLIINVDEFVFTTEAHLLPLSIAQLGNATFSFRQTDEHNVLD---FMRTCPSSNRLFP------E 530
            |:|.::::::||||||||||.::....:......|.|:..||   |..|||::..|||      :
Human   479 DIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQ 543

  Fly   531 KVRKPLRNFITGSCP----------RTTAGKRLSALDFQASNADHLRAVYDMGITMVSVGDRSQG 585
            .:|:||:|.:..|||          |:.|...|.|.||.|:|.:||..:..||::::.:.|   |
Human   544 SIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKD---G 605

  Fly   586 KVRLFHSFYNAKSHEEGEMGLQFMQEMLELTKMQSINQLAQLQAVAYATDENSQDW---IALMAG 647
            :|:|......|.|..:.|.||:|||||:||:..|...|....:||...    |..:   :.|.||
Human   606 RVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIV----SHPFFGRVVLTAG 666

  Fly   648 PSHFSPELTGDQFVEGDVILAKPLRACDESLENAEEAKGKVLVAERGDCTFVSKARLAQKVGAAA 712
            |:.|..:|:..:...|.|..:||...|.| |.|.|...||:.:.:||.|.|..|||..|..||..
Human   667 PAQFGLDLSKHKETRGFVASSKPSNGCSE-LTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIG 730

  Fly   713 LIVCDNVPGSSGETQPMFAMSGDGK--DDVLIPVVFMYSME 751
            .||.|:..|||.:|.|:|.|:||||  ||:.||::|::|.|
Human   731 GIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKE 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	270/438 (62%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041	47/109 (43%)
EDEM3	NP_001306889.1	Glyco_hydro_47	59..498	CDD:279825	270/438 (62%)
		PA_EDEM3_like	664..789	CDD:239041	47/109 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	945..948
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149715
Domainoid	1	1.000	598	1.000	Domainoid score	I197
eggNOG	1	0.900	-	-		E1_KOG2430
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11866
Inparanoid	1	1.050	756	1.000	Inparanoid score	I562
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48000
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	1	1.000	-	-		oto90414
orthoMCL	1	0.900	-	-		OOG6_105609
Panther	1	1.100	-	-	LDO	PTHR45679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770