DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem2 and Edem3

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	XP_006529858.1	Gene:	Edem3 / 66967	MGIID:	1914217	Length:	948	Species:	Mus musculus

Alignment Length:	757	Identity:	381/757 - (50%)
Similarity:	524/757 - (69%)	Gaps:	38/757 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AMCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRG 86
            |:|:|:|..:.|....|   ||.:|:.:|..:..:||.|||..||::||||||||||:|:||.||
Mouse    28 ALCLVLATSVCTAGAAP---MSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRG 89

  Fly    87 VTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVG 151
            ..|||||:||.||.||:||:|:|||||:|....||:.||:.|:|||..|:|::|||||||||::|
Mouse    90 QEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLG 154

  Fly   152 GLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKDPMLKK 216
            |||..|.||..|::..:.|.||..|||.|:::|||:|||||||::|:|:.|:||:.|::.|..:.
Mouse   155 GLLGGHSLAIMLKEKGEHMQWYNDELLHMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEART 219

  Fly   217 SRE--TCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVR 279
            ..|  ||||||||::||||||||.||..|||..|..|:|.||:.|.|.|:|:|..:|:|:|||||
Mouse   220 GTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVR 284

  Fly   280 RDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFM 344
            :|||||||||||||||.|:|||||||.:|.|||.||:|:|:|:|:.|:||||.:|:|...::.:|
Mouse   285 KDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWM 349

  Fly   345 DSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQHPLRPEFIESTYFL 409
            |:||||:||||||.||::||::||||||||::.|.|:|||||.||::||.||||||||.||||||
Mouse   350 DALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFL 414

  Fly   410 YRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQ 474
            |:||||.:||:|||..::.|.::|:|.||:||:.|||||.||||||||.|:|..|||:|||:|.:
Mouse   415 YKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKE 479

  Fly   475 DLIINVDEFVFTTEAHLLPLSIAQLGNATFSFRQTDEHNVLD---FMRTCPSSNRLFP------E 530
            |:|.::::::||||||||||.::....:......|.|:..||   |..|||::..|||      :
Mouse   480 DIIFDIEDYIFTTEAHLLPLWLSTTNRSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQ 544

  Fly   531 KVRKPLRNFITGSCP-----------RTTAGKRLSALDFQASNADHLRAVYDMGITMVSVGDRSQ 584
            .:|:||:|.:..|||           |:.|...|.|.||.|:|.:||..:..||::::.:.|
Mouse   545 SIREPLKNVVDKSCPRGIIRVREESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKD--- 606

  Fly   585 GKVRLFHSFYNAKSHEEGEMGLQFMQEMLELTKMQSINQLAQLQAVAYATDENSQDW---IALMA 646
            |:|:|......|.|..:.|.||:|||||:||:..|...|....:||...    |..:   :.|.|
Mouse   607 GRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQII----SHPFFGRVVLTA 667

  Fly   647 GPSHFSPELTGDQFVEGDVILAKPLRACDESLENAEEAKGKVLVAERGDCTFVSKARLAQKVGAA 711
            ||:.|..:|:..:...|.|..:||...|.| |.|.|...||:.:.:||.|.|..|||..|..||.
Mouse   668 GPAQFGLDLSKHKETRGFVASSKPYNGCSE-LTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAI 731

  Fly   712 ALIVCDNVPGSSGETQPMFAMSGDGK--DDVLIPVVFMYSME 751
            ..||.|:..|||.:|.|:|.|:||||  ||:.||::|::|.|
Mouse   732 GGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKE 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	270/438 (62%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041	47/109 (43%)
Edem3	XP_006529858.1	Glyco_hydro_47	60..499	CDD:366693	270/438 (62%)
		PA_EDEM3_like	666..791	CDD:239041	47/109 (43%)
		DUF4521	821..>914	CDD:373483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839767
Domainoid	1	1.000	598	1.000	Domainoid score	I198
eggNOG	1	0.900	-	-		E1_KOG2430
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11866
Inparanoid	1	1.050	757	1.000	Inparanoid score	I554
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48000
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	1	1.000	-	-		oto93999
orthoMCL	1	0.900	-	-		OOG6_105609
Panther	1	1.100	-	-	LDO	PTHR45679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R726
SonicParanoid	1	1.000	-	-		X4121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790