DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem2 and edem3

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	XP_005166989.2	Gene:	edem3 / 559811	ZFINID:	ZDB-GENE-070801-5	Length:	888	Species:	Danio rerio

Alignment Length:	771	Identity:	387/771 - (50%)
Similarity:	527/771 - (68%)	Gaps:	43/771 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIFLVAMCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCK 81
            |:|.:..||.:           ::.||..|:::||.:..:||.|||..||.:||||||||||:|:
Zfish    15 LLFFMGTCIRL-----------SETMSRDEKSKLRIQVLEMFDHAYRNYMDHAYPADELMPLTCR 68

  Fly    82 GRYRGVTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETN 146
            ||.||:.|||||:||.||.||:||:||||||.||....||:.||:.|::||:.|:||:|||||||
Zfish    69 GRVRGLEPSRGDVDDALGKFSLTLIDTLDTLALLNKTVEFEEAVRRVVKDVRLDNDIVVSVFETN 133

  Fly   147 IRMVGGLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKD 211
            ||::||||..|.:|..|:::.. |.||:.|||.|:::||.|||||||||:|:|:.|||||.|:..
Zfish   134 IRVLGGLLGGHSMAVMLKENGQ-MVWYQNELLHMAKDLGLRLLPAFNTSSGLPYPRVNLRHGVHG 197

  Fly   212 PMLK--KSRETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHS 274
            |..:  ...||||||||||:||||||||.||||.||..|..|:|.||:.|.|.|:|:||.:|:||
Zfish   198 PETRTGTETETCTACAGTIILEFAALSRFTGDPTFEAHARRALDFLWEKRQRNSNLVGTTINIHS 262

  Fly   275 GDWVRRDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAK 339
            |:|||||||||||||||||||.|:|:|||||:.|.|||.||.::|||:|:.|:||||.:|:|...
Zfish   263 GEWVRRDSGVGAGIDSYYEYLMKAYILLGDDQLLLRFNTHYASIMKYISQPPLLLDVHIHKPLLP 327

  Fly   340 SKNFMDSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQHPLRPEFIE 404
            ::.:|||||||:||||||.||::||::||||||||.:.|.|:|||||.||::||.||||||||.|
Zfish   328 ARTWMDSLLAFFPGLQVLKGDIRPAIETHEMLYQVTKKHNFLPEAFTTDFRVHWAQHPLRPEFAE 392

  Fly   405 STYFLYRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLL 469
            ||||||:||.|.:||:||:..|:.|.:.|:|.||:||:.|||||.||||||||.|:|..||||||
Zfish   393 STYFLYKATRDPYYLEVGRTVLENLNRFARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLFLL 457

  Fly   470 FSDPQDLIINVDEFVFTTEAHLLPLSIAQLGNA----TFSFRQTDEHNVLDFMRTCPSSNRLFPE 530
            |::.:||..||:::||||||||||||::...|:    ..:....:|.:.|:|..|||::..|||:
Zfish   458 FAEEEDLPFNVEDYVFTTEAHLLPLSLSTASNSPAPPVINSVVIEELDDLNFEWTCPNTRLLFPD 522

  Fly   531 -----KVRKPLRNFITGSCPRTTAGKR-------LSALDFQASNADHLRAVYDMGITMVSVGDRS 583
                 ..|:|:|:.:..||.|..|.:.       |.|.||.|:|.:||..:..||::::.:.|
Zfish   523 PAFPRNFREPIRSAVDKSCLRPIAHREPGMGRPPLRAQDFMANNPEHLELLRRMGVSLIHLKD-- 585

  Fly   584 QGKVRLFHSFYNAKSHEEGEMGLQFMQEMLELTKMQSINQL--AQLQAVAYATDENSQDWIALMA 646
             |:|:|......|.|....|.|::|||||:||:..|...||  ..:|.|::.....    :.|.|
Zfish   586 -GRVQLVQHATQAVSAVAAEDGMRFMQEMMELSSQQQKEQLPPRAVQIVSHPFFGR----VVLTA 645

  Fly   647 GPSHFSPELT-GDQFVEGDVILAKPLRACDESLENAEEAKGKVLVAERGDCTFVSKARLAQKVGA 710
            ||:.|..:|: ....|.|.|.:|:|...|.| |.|.|...|::.:.:||.|.|..|||..||.||
Zfish   646 GPAQFGMDLSKSSSGVRGFVTVAEPYNGCSE-LSNGEIVAGRIALLQRGQCMFAEKARHVQKAGA 709

  Fly   711 AALIVCDNVPGSSGETQPMFAMSGDGK--DDVLIPVVFMYSMEFGKLSAVMQRRKQ 764
            ...||.|:..|||.:|.|:|.|:|||:  |||.:|::|::..|...|...::..|:
Zfish   710 IGGIVIDDNEGSSSDTAPLFQMAGDGRNTDDVTLPLLFLFHKEGNILLEALKEYKE 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	279/438 (64%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041	48/123 (39%)
edem3	XP_005166989.2	Glyco_hydro_47	44..482	CDD:307602	279/438 (64%)
edem3	XP_005166989.2	PA_EDEM3_like	644..770	CDD:239041	48/123 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583854
Domainoid	1	1.000	624	1.000	Domainoid score	I171
eggNOG	1	0.900	-	-		E1_KOG2430
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11866
Inparanoid	1	1.050	745	1.000	Inparanoid score	I564
OMA	1	1.010	-	-		QHG48000
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	1	1.000	-	-		otm25972
orthoMCL	1	0.900	-	-		OOG6_105609
Panther	1	1.100	-	-	LDO	PTHR45679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R726
SonicParanoid	1	1.000	-	-		X4121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800