Protein Alignment Edem2 and EDEM2

DIOPT Version :10

• Sequence 1: NP_609611.1
• Gene: Edem2 / 34714
• FlyBaseID: FBgn0032480
• Length: 801
• Species: Drosophila melanogaster
• Sequence 2: NP_060687.2
• Gene: EDEM2 / 55741
• HGNCID: 15877
• Length: 578
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 227/600 - (37%)
• Similarity: 327/600 - (54%)
• Gaps: 93/600 - (15%)

  Fly    16 MLIFLVAMCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSC 80
            :||.|..:|    .:|......|..:.|..:.|..||..:.||||||::|::||:|.|||.||:|
Human     5 LLIPLGLLC----ALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPLTC 65

  Fly    81 KGRYRGVTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFET 145
            .|.            |..|:||:||:|.||||::||:.:||...|:::...|.||.|:..|||||
Human    66 DGH------------DTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFET 118

  Fly   146 NIRMVGGLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGM- 209
            |||:||||||||:|::......:......|.||.|:.|...:|||||.|.||:|:..|||..|:
Human   119 NIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVN 183

  Fly   210 --KDPMLKKSRETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSD--LMGTVL 270
              :.|:      ||||..||.::|||.||.|||||:||..|..|:..||:.|   ||  |:|..:
Human   184 PGETPV------TCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESR---SDIGLVGNHI 239

  Fly   271 NVHSGDWVRRDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHR 335
            :|.:|.||.:|:|:|||:|||:|||.|..:||.|.|.:|.|..:..|:..|.......|.|.|::
Human   240 DVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYK 304

  Fly   336 PHAKSKNFMDSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQ----MHTF--IPEAFTVDFQIHWG 394
            .......| .||.|:|||||.|.||:..|::|....|.|.:    :..|  ||:.:||:.:   .
Human   305 GTVSMPVF-QSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR---E 365

  Fly   395 QHPLRPEFIESTYFLYRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVL 459
            .:|||||.|||..:|||||||...|::|:.|::::::.:||.||:|.:.|:|..|.::||:||.|
Human   366 GYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFL 430

  Fly   460 SETIKYLFLLFSDPQDLIIN------------------VDEFVFTTEAHLLPLSIAQLGNATFSF 506
            :||:|||:||| ||.:.|.|                  ...::|.||||  |:..|.| :.....
Human   431 AETVKYLYLLF-DPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAH--PIDPAAL-HCCQRL 491

  Fly   507 RQTDEHNVLDFMRTCPSSNR-----------------------LF-PE-----KVRKPLRNFI-T 541
            :: ::..|.|.||...|..|                       || ||     :.|||.:..: .
Human   492 KE-EQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPL 555

  Fly   542 GSCPRTTAGKRLSAL 556
            .|||......:|:.|
Human   556 LSCPSQPFTSKLALL 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:460241	196/465 (42%)
		PA_EDEM3_like	645..770	CDD:239041
EDEM2	NP_060687.2	Glyco_hydro_47	42..480	CDD:460241	196/465 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..557		7/39 (18%)