DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem2 and Edem1

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_001259152.1	Gene:	Edem1 / 31154	FlyBaseID:	FBgn0023511	Length:	1004	Species:	Drosophila melanogaster

Alignment Length:	926	Identity:	283/926 - (30%)
Similarity:	434/926 - (46%)	Gaps:	205/926 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRGV 87
            :|.|:..:|||..:...| .|...:.||||:.|.||.|||:.|:::|...|||.||:|.|.
  Fly    15 ICAVLLVLLSTGVSGQKQ-YSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPLTCDGH---- 74

  Fly    88 TPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVGG 152
                    |..|::|:||:|.||||..:|:||||..|.:|:...:.||.||.|||||||||:|||
  Fly    75 --------DTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGG 131

  Fly   153 LLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKDPMLKKS 217
            |||||:|::......:.....||.||.::.::..||||||.|:||:|:..||||.|:..   .::
  Fly   132 LLSAHLLSKRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRYGVPK---GET 193

  Fly   218 RETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVRRDS 282
            ..||||..||.|:||..||||||..|:|..|..|:.|||..| ....|.|..::|.||.|...||
  Fly   194 SITCTAGVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYR-SPIGLFGNHIDVQSGRWTALDS 257

  Fly   283 GVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFMDSL 347
            |:|||:||.:|||.|:.|||...:.|..|:....|:.||:.:....:.|.|::.......| .||
  Fly   258 GIGAGVDSLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVF-QSL 321

  Fly   348 LAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTV---DFQIHWGQHPLRPEFIESTYFL 409
            .|||||:..:.||.:||::|......|.:.:.|:||.:.:   :...:...:|||||.|||..:|
  Fly   322 EAFWPGILSIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYL 386

  Fly   410 YRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQ 474
            |||||:.:.|:.|:..|:||:..||..||||.:.:|.|.:.|:||:||.|:||.|||:|||.:..
  Fly   387 YRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLFDEEN 451

  Fly   475 DL-----------------IINVDEFVFTTEAHLLPLSIAQLGNATFSFRQTDEHNVLDFMR--- 519
            .|                 ::....::|.||||.:.:|.....:|    ...|.:..||..|
  Fly   452 FLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCHA----HNEDIYTSLDLQRFSP 512

  Fly   520 --------------------TC-PSSNRLF---PEKVR-----KPLRNFITGSCPRTTAGKRLSA 555
                                .| |.:|..|   .|.|:     |......:|:  .||....:..
  Fly   513 RAILERSKKRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQEREQSGT--STTMAVDIEV 575

  Fly   556 LD-FQ-------ASNADHLRAVYDMGITM---------VSVGDRSQGKVRLFHSFYNAK---SHE 600
            .| ||       .||.:.:|...::..::         ::|.|..:...:...||.:|.   ::.
  Fly   576 FDEFQQPAGDLLVSNFEQIREERELNESLHRNVVARNQLTVSDLDEFFAQRRESFASASEALNYV 640

  Fly   601 EGEM-----------GLQF----MQEMLEL-------TKMQSINQLAQLQAVAYATDENSQDWIA 643
            :..|           |||.    |..:|..       ::|:::.||.:||. .|..:......:.
  Fly   641 KTFMGNYTMDVAFIRGLQLYDTNMSSVLGTGAQKEYESRMRTLWQLYELQQ-QYVANIRVIQGLG 704

  Fly   644 LMAGPSHFSPELTGDQFVEGDVI---LAKPLRACDES--LE--NAEEAKGKVLVAERGDCTFVSK 701
            |:..|:            :||.|   |.:.|.:.|:|  ||  :.::.:.:|..........:.:
  Fly   705 LLTFPA------------DGDRIPSHLTEVLDSLDKSAHLEHMDLQDLETRVSNTSSPQLAHIRE 757

  Fly   702 ARL-AQKVGAAALIVCDNVPGSSGETQPM--FA----MSGDGKDDVLI-PVVFMYSMEFGKLSAV 758
            ..| |:...|.|::          .|..|  ||    :||..:..|.| |:     :|.|:||.
  Fly   758 VILKARNAYAIAMV----------NTSAMQEFAIRIYLSGTSEAGVRIHPL-----LEDGELSE- 806

  Fly   759 MQRRKQPLRVR--------VMQMVEFKRWQLA------------------KE------------- 784
             :.||:||::.        ..::|:|:: ::|                  ||
  Fly   807 -EARKRPLKLAEERALFSYARRIVDFRK-RMAETVDRLQTLMQDIPPPKRKEATTDSQAADASTV 869

  Fly   785 --QRQNQTASVAQKPE 798
              |.:.|.|:.||:||
  Fly   870 YTQTKAQMAAPAQQPE 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	187/456 (41%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041	32/147 (22%)
Edem1	NP_001259152.1	Glyco_hydro_47	48..486	CDD:279825	187/454 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453093
Domainoid	1	1.000	275	1.000	Domainoid score	I265
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	1	1.000	-	-		otm46476
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950