DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Edem2 and Edem1

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_001292208.1	Gene:	Edem1 / 297504	RGDID:	1563633	Length:	650	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	209/464 - (45%)
Similarity:	296/464 - (63%)	Gaps:	24/464 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRGV-TPSRGDMDDILGNFSMTLVDTLD 110
            ||::|:.||.||...|:.||.:|:|.|||.|:.|:||...: .||..:::|:|||:|:||||.||
  Rat   120 RAQMRDLARGMFVFGYDNYMAHAFPQDELNPIYCRGRGPDLGDPSNLNINDVLGNYSLTLVDALD 184

  Fly   111 TLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVGGLLSAH-ILAEYLQKHAD-TMHWY 173
            ||.::|:.:||..||||||..|.||.|..|.|||..||::|.||||| |:.:..|...| |:..|
  Rat   185 TLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIEDY 249

  Fly   174 KGELLEMSRELGYRLLPAF-NTSTGIPHARVNLRLGMKDPMLKKSRETCTACAGTILLEFAALSR 237
            ..|||.|:.:|..|||||| ||.||||:.||||:.|:..   ..:.|||||.||::|:||..|||
  Rat   250 DNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPP---DSNNETCTAGAGSLLVEFGILSR 311

  Fly   238 LTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVRRDSGVGAGIDSYYEYLFKSYVLL 302
            |.||..||..|..|:.|||.||...:.|:|.|:|:.:|.||.:.||:|||:||:||||.|||:|.
  Rat   312 LLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILF 376

  Fly   303 GDDKYLARFNRHYNAVMKYVSEG-----------PMLLDVLMHRPHAKSKNFMDSLLAFWPGLQV 356
            |:.:.|..||..|.::..|:..|           |:.::|.|......: .::|||.||:|||||
  Rat   377 GEKEDLEMFNAAYQSIQSYLRRGREACNEGEGDPPLYVNVNMFSGQLMN-TWIDSLQAFFPGLQV 440

  Fly   357 LSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQ---HPLRPEFIESTYFLYRATGDHHY 418
            |.||::.|:..|...|.:.:.:..:||.:  ::|:....   :|||||.:||||.||:||.:..|
  Rat   441 LIGDVEDAICLHAFYYAIWKRYGALPERY--NWQLQAPDVLFYPLRPELVESTYLLYQATKNPFY 503

  Fly   419 LQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQDLIINVDEF 483
            |.||...|::|:::.||.||||.::.|.....||||:||.||||.|||:|||.:...:..:...:
  Rat   504 LHVGMDILQSLEKYTKVKCGYATLHHVIDKSKEDRMESFFLSETCKYLYLLFDEENPVHKSGTRY 568

  Fly   484 VFTTEAHLL 492
            :||||.|::
  Rat   569 MFTTEGHII 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	204/454 (45%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041
Edem1	NP_001292208.1	Glyco_hydro_47	130..575	CDD:279825	203/450 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920