Protein Alignment Edem2 and MAN1A2

DIOPT Version :10

• Sequence 1: NP_609611.1
• Gene: Edem2 / 34714
• FlyBaseID: FBgn0032480
• Length: 801
• Species: Drosophila melanogaster
• Sequence 2: NP_006690.1
• Gene: MAN1A2 / 10905
• HGNCID: 6822
• Length: 641
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 163/530 - (30%)
• Similarity: 250/530 - (47%)
• Gaps: 86/530 - (16%)

  Fly    31 LSTETTMPTQNMSNKER------------------------AELREEARDMFYHAYNAYMQNAYP 71
            :.||.....|.|..||.                        .|.||:.::|..||::.|....:.
Human   137 IQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNYRTYGWG 201

  Fly    72 ADELMPLSCKGRYRGVTPSRGDMDDILGNFSM--TLVDTLDTLVLLGDFTEFDHAVKLVIRDVQF 134
            .:||.|::.||.    :|      :|.|:..|  |:||.||||.::|...||....:.:..::.|
Human   202 HNELRPIARKGH----SP------NIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDF 256

  Fly   135 DSDIIVSVFETNIRMVGGLLSAHILAEYLQKHADTMHWYKGELLEMSR--ELGYRLLPAFNTSTG 197
            ..:..|||||.|||.:||||:|:.|:              ||.:...:  :|..:|||||||.||
Human   257 SVNSEVSVFEVNIRFIGGLLAAYYLS--------------GEEIFKIKAVQLAEKLLPAFNTPTG 307

  Fly   198 IPHARVNLRLGM-KDPMLKKSRETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHR 261
            ||.|.|||:.|: ::.....:..:..|..||:.:||..||.||||..:..:.......|.|: .|
Human   308 IPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKM-DR 371

  Fly   262 GSDLMGTVLNVHSGDWVRRDSGVGAGIDSYYEYLFKSYVLLGDDKYLAR--FNRHYNAVMKYV-- 322
            .:.|....||..:|.|.:..:.||...||:||||.|::::.....:.||  ::....|:.|::
Human   372 PNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIK 436

  Fly   323 -SEGPMLLDVLMHRPHAKSKNFMDSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQM--------- 377
             |.|.:.........|.:.|  |..|..|..|:..|..|...|.:....|....::
Human   437 KSRGGLTFIGEWKNGHLEKK--MGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYD 499

  Fly   378 HTFI---PEAFTVDFQIH-------WGQHPLRPEFIESTYFLYRATGDHHYLQVGKKALKTLQQH 432
            .|.:   ||:|..|..:.       ...:.||||.||:.::|:|.|.|..|.|.|.:|...::::
Human   500 RTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKY 564

  Fly   433 AKVSCGYAAVNDV--RTGKHEDRMDSFVLSETIKYLFLLFSDPQDLIINVDEFVFTTEAHLLPLS 495
            .:|:.|::.|.||  .|..|:|...||.|:||:|||:||||.  |.::.:|.:||.||||  ||.
Human   565 CRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSG--DDLLPLDHWVFNTEAH--PLP 625

  Fly   496 IAQLGNATFS 505
            :..|.|.|.|
Human   626 VLHLANTTLS 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:460241	148/467 (32%)
		PA_EDEM3_like	645..770	CDD:239041
MAN1A2	NP_006690.1	ATP-synt_Fo_b	<110..149	CDD:473877	3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..175		0/21 (0%)
		Glyco_hydro_47	187..626	CDD:460241	150/469 (32%)