DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem2 and Edem2

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	NP_663512.2	Gene:	Edem2 / 108687	MGIID:	1915540	Length:	577	Species:	Mus musculus

Alignment Length:	555	Identity:	216/555 - (38%)
Similarity:	317/555 - (57%)	Gaps:	68/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MLIFLVAMCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSC 80
            :||.|..:|:    :|......|..:.:..:.|..||..:.||||||::|::||:|.|||.||:|
Mouse     5 LLIPLGLVCV----LLPLHHGAPGPDGTAPDPAHYRERVKAMFYHAYDSYLENAFPYDELRPLTC 65

  Fly    81 KGRYRGVTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFET 145
            .|.            |..|:||:||:|.||||::||:.:||...|:::..:|.||.|:..|||||
Mouse    66 DGH------------DTWGSFSLTLIDALDTLLILGNTSEFQRVVEVLQDNVDFDIDVNASVFET 118

  Fly   146 NIRMVGGLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGM- 209
            |||:||||||||:|::......:......|.||.|:.|...:|||||.|.||:|:..|||..|:
Mouse   119 NIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVN 183

  Fly   210 --KDPMLKKSRETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSD--LMGTVL 270
              :.|:      ||||..||.::|||.||.|||||:||..|..|:..||:.|   ||  |:|..:
Mouse   184 PGETPV------TCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESR---SDIGLVGNHI 239

  Fly   271 NVHSGDWVRRDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHR 335
            :|.:|.||.:|:|:|||:|||:|||.|..:||.|.|.:|.|..:..|:..|.......|.|.|::
Mouse   240 DVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTHFDDWYLWVQMYK 304

  Fly   336 PHAKSKNFMDSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQ----MHTF--IPEAFTVDFQIHWG 394
            .......| .||.|:|||||.|.||:..|::|....|.|.:    :..|  ||:.:||:.:   .
Mouse   305 GTVSMPVF-QSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR---E 365

  Fly   395 QHPLRPEFIESTYFLYRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVL 459
            .:|||||.|||..:|||||||...|::|:.|::::::.:||.||:|.:.|:|..|.::||:||.|
Mouse   366 GYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFL 430

  Fly   460 SETIKYLFLLFSDPQDLIIN------------------VDEFVFTTEAHLLPLSIAQLGNATFSF 506
            :||:|||:||| .|.:.|.|                  ...::|.||||  |:..|    |....
Mouse   431 AETVKYLYLLF-HPNNFIHNNGSTFDSVMTPHGECILGAGGYIFNTEAH--PIDPA----ALHCC 488

  Fly   507 RQTDEH--NVLDFMRTCPSSNRLFPEKV-RKPLRN 538
            |:..|.  .|.|.::...|..:..|::. ||.:|:
Mouse   489 RRLKEEQWEVEDLIKEFYSLKQSRPKRAQRKTVRS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	195/465 (42%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041
Edem2	NP_663512.2	Glyco_hydro_47	42..480	CDD:307602	194/466 (42%)
Edem2	NP_663512.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..561		4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850