DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edem2 and edem3

DIOPT Version :9

Sequence 1:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster
Sequence 2:	XP_017949129.2	Gene:	edem3 / 100145667	XenbaseID:	XB-GENE-5811499	Length:	918	Species:	Xenopus tropicalis

Alignment Length:	810	Identity:	394/810 - (48%)
Similarity:	545/810 - (67%)	Gaps:	59/810 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MCIVVA-CVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRG 86
            |.:|:| |:|.......|:    :|:|:||.:..:||.|||.:|||:||||||||||:|:||.||
Frog    14 MWLVLAFCLLGQGRAAVTK----EEKAQLRSQVLEMFDHAYGSYMQHAYPADELMPLTCRGRIRG 74

  Fly    87 VTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVG 151
            ..|||||:||.||.||:||:|||||||:|....||:.||:.||.||..|:||:|||||||||::|
Frog    75 QEPSRGDVDDALGKFSLTLIDTLDTLVVLNKTNEFEDAVRKVITDVNLDNDIVVSVFETNIRVLG 139

  Fly   152 GLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKDPMLKK 216
            |||..|.||..|::::|.|.||..|||.|::||||:|||||||::|:|:.|:||:.|::.|..:.
Frog   140 GLLGGHSLAIMLKENSDRMQWYNDELLHMAKELGYKLLPAFNTTSGLPYPRINLKFGIRSPEART 204

  Fly   217 SRE--TCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVR 279
            ..|  ||||||||::||||||||.||..:||..|..|:|.||:.|.|.|:|:|..:|:|:|||||
Frog   205 GTETDTCTACAGTMILEFAALSRFTGIAVFEEHARKALDFLWEKRQRSSNLVGVTINIHTGDWVR 269

  Fly   280 RDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFM 344
            :|||||||||||||||.|:|||||||.||.|||.||:|:|:|:|:.|:||||.:|:|...::.:|
Frog   270 KDSGVGAGIDSYYEYLLKAYVLLGDDSYLERFNTHYDAIMRYISQPPLLLDVHIHKPMLTARTWM 334

  Fly   345 DSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQHPLRPEFIESTYFL 409
            ||||||:||||||.||::||::||||||||::.|.|:|||||.||::||.||||||||.||||||
Frog   335 DSLLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFL 399

  Fly   410 YRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQ 474
            |:||||.:||:||:..:..|.::|:|.||:|||.|||||.||||||||.|:|..|||:||||:.:
Frog   400 YKATGDPYYLEVGRTLIDNLNKYARVPCGFAAVKDVRTGSHEDRMDSFFLAEMFKYLYLLFSERE 464

  Fly   475 DLIINVDEFVFTTEAHLLPLSIAQLG------NATFSFRQTDEHNVLDFMRTCPSSNRLF----- 528
            |||.:::.::|||||||||||::...      |.|..:.:.|:.|   |..:||::..||
Frog   465 DLIFDIESYIFTTEAHLLPLSLSTASQTSTKKNTTSQYTELDDSN---FDWSCPNTQILFRNDPM 526

  Fly   529 -PEKVRKPLRNFITGSCPRTT--------AGKR--LSALDFQASNADHLRAVYDMGITMVSVGDR 582
             .:.:|:|::|.:..:|||:.        :|.:  |.|.||.|:|::||..:..||::::.:.|
Frog   527 YAQNIREPVKNVVDKNCPRSPSRLDEVSGSGNKPPLRARDFMATNSEHLEILKKMGVSLIHLKD- 590

  Fly   583 SQGKVRLFHSFYNAKSHEEGEMGLQFMQEMLELTKMQSINQLAQLQAVAYATDENSQDWIALMAG 647
              |:|:|......|.|..:.|.||:|||||:||:..|...|....:||...: ......:.|.||
Frog   591 --GRVQLVQHANQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVS-HPFYGRVVLTAG 652

  Fly   648 PSHF----SPELTGDQFVEGDVILAKPLRACDESLENAEEAKGKVLVAERGDCTFVSKARLAQKV 708
            |:.|    |..|.|   ..|.|..|:|...|.: :.|....:||:.:.:||.|.|..|||..||.
Frog   653 PAQFGMDLSKHLAG---ARGLVARAEPYSGCSD-ITNGAAIQGKIALMQRGQCMFAEKARNVQKA 713

  Fly   709 GAAALIVCDNVPGSSGETQPMFAMSGDGK--DDVLIPVVFMYSMEFGKLSAVMQRRKQPLRVRVM 771
            ||...||.|:..|||.:|.|:|.|:||||  ||:.||::|::|.| |.:  ::.      .:|..
Frog   714 GAIGGIVIDDNEGSSSDTAPLFQMAGDGKNTDDITIPMLFLFSKE-GNI--ILD------AIREY 769

  Fly   772 QMVEFKRWQLAKEQ----RQNQTASVAQKP 797
            |.||......||::    :..:.....|||
Frog   770 QQVEVLLSDKAKDRATIFKDLENEGGEQKP 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	277/438 (63%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041	48/130 (37%)
edem3	XP_017949129.2	Glyco_hydro_47	45..484	CDD:396217	277/438 (63%)
edem3	XP_017949129.2	PA_EDEM3_like	650..776	CDD:239041	52/138 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	606	1.000	Domainoid score	I195
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11866
Inparanoid	1	1.050	752	1.000	Inparanoid score	I565
OMA	1	1.010	-	-		QHG48000
OrthoDB	1	1.010	-	-		D253774at33208
OrthoFinder	1	1.000	-	-		FOG0000713
OrthoInspector	1	1.000	-	-		oto104220
Panther	1	1.100	-	-	LDO	PTHR45679
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080