DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and LINGO1

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_116197.4	Gene:	LINGO1 / 84894	HGNCID:	21205	Length:	620	Species:	Homo sapiens

Alignment Length:	624	Identity:	145/624 - (23%)
Similarity:	225/624 - (36%)	Gaps:	134/624 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 DRSELTYLPQRFL----GELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLF 319
            ||:.|.: .:||:    |..:|.|:|:|.:|.:..|.:|.|.....||.|.|:.|.:|.:....|
Human    52 DRAVLCH-RKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAF 115

  Fly   320 QTAADLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLS 384
            ....:|:.|.|..|||...|...|.....|.:|.:..|::..:..:....|..|:.|::..|.|.
Human   116 NNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 180

  Fly   385 VIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLR 449
            .|..:||..|:.|..|.:...|||.:.:.....||.|..|.|.......:....|:|...|.:|.
Human   181 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLE 245

  Fly   450 IDETPIEQFSNWISRYDESLVDPQVLH----RLRYLSVQQNRKLTYLPATLFANTP-------NI 503
            |...|..........|..:|....:.|    .:.||:|   |.|.||.....:..|       .:
Human   246 ISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAV---RHLVYLRFLNLSYNPISTIEGSML 307

  Fly   504 RELLLAENGLLQL---------PTQISGLSRLQRLSVRGNSLGSLPENI-KELRQLHYLNILGNE 558
            .|||..:.  :||         |....||:.|:.|:|.||.|.:|.|:: ..:..|..|.:..|.
Human   308 HELLRLQE--IQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNP 370

  Fly   559 YQCDCSMYWL--TAWLANTSTSLRHQMPQAQNHSNGSTNQTP--LDSYESIDHQIDALKCQYGYR 619
            ..|||.:.|:  ..|..|    ...|.|         |..||  :...|..|.. |.|...|
Human   371 LACDCRLLWVFRRRWRLN----FNRQQP---------TCATPEFVQGKEFKDFP-DVLLPNY--- 418

  Fly   620 GDMLRVLSKLNCSVPTVVQFSEPKMHKLL----STAKLECQISGSPVPDIIWVTPRNKILRHHAD 680
                     ..|   ...:..:.|..::.    .|.:..|:..|.|.|.|:|::||    :|
Human   419 ---------FTC---RRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPR----KH--- 464

  Fly   681 PDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRID 745
                  ::.:|.:.                                |:.:..:|:|.|......|
Human   465 ------LVSAKSNG--------------------------------RLTVFPDGTLEVRYAQVQD 491

  Fly   746 SGLYTCYAFNVMGKASAGLRLYI------------DPIVFYRVKIGSILFGTALATA---FLLLT 795
            :|.|.|.|.|..|..|....|::            ....|...:.|.....:..||.   |.:.|
Human   492 NGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKT 556

  Fly   796 LIVQGLRSCLSRWGICNRFYCCVN----RKKKSPRKHQI 830
            ||:......:|..|:.  .:|.|.    .:.|...||.|
Human   557 LIIATTMGFISFLGVV--LFCLVLLFLWSRGKGNTKHNI 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	51/177 (29%)
		LRR_8	251..311	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	6/20 (30%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	15/57 (26%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		LRR_RI	351..>557	CDD:238064	56/226 (25%)
		LRR_8	371..431	CDD:290566	18/59 (31%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	21/74 (28%)
		leucine-rich repeat	478..502	CDD:275380	8/30 (27%)
		leucine-rich repeat	503..526	CDD:275380	8/31 (26%)
		Ig	<714..761	CDD:299845	11/46 (24%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	7/23 (30%)
		LRR	<66..371	CDD:227223	82/309 (27%)
		LRR 1	72..93		8/20 (40%)
		leucine-rich repeat	73..96	CDD:275380	7/22 (32%)
		LRR 2	96..117		7/20 (35%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		LRR_8	120..179	CDD:338972	15/58 (26%)
		LRR 3	120..141		8/20 (40%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR 4	144..165		3/20 (15%)
		leucine-rich repeat	145..192	CDD:275380	12/46 (26%)
		LRR 5	168..189		7/20 (35%)
		LRR 6	192..213		5/20 (25%)
		leucine-rich repeat	193..216	CDD:275380	6/22 (27%)
		LRR 7	216..237		4/20 (20%)
		leucine-rich repeat	217..264	CDD:275380	10/46 (22%)
		LRR 8	264..285		5/23 (22%)
		leucine-rich repeat	265..288	CDD:275380	7/25 (28%)
		LRR 9	288..309		3/20 (15%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		LRR 10	312..333		3/22 (14%)
		leucine-rich repeat	313..336	CDD:275380	5/24 (21%)
		LRR 11	336..357		8/20 (40%)
		leucine-rich repeat	337..357	CDD:275380	8/19 (42%)
		PCC	341..>421	CDD:188093	25/105 (24%)
		Ig	439..514	CDD:386229	24/119 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920