DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and RLP12

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_177296.2	Gene:	RLP12 / 843481	AraportID:	AT1G71400	Length:	847	Species:	Arabidopsis thaliana

Alignment Length:	906	Identity:	192/906 - (21%)
Similarity:	321/906 - (35%)	Gaps:	299/906 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 WQSSELKDETLMELFTRQPRSF--------------EYMERLNLAENRLEC-LHWAIPLAVRRVK 230
            |......|::...:....|.:|              :|:..|:|.    .| |:..||.::
plant    74 WNGVTCNDKSGQVISLDIPNTFLNNYLKTNSSLFKLQYLRHLDLT----NCNLYGEIPSSL---- 130

  Fly   231 VLEMSGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLT-ELPRDI 294
                 || ||:.:|:||.:.|.:.|:...           :|.|::||.|.|:.|:|| |:|..:
plant   131 -----GN-LSHLTLVNLYFNKFVGEIPAS-----------IGNLNQLRHLILANNVLTGEIPSSL 178

  Fly   295 FVGAL-KLERLYLSGNRL-SVLPFMLFQTAADLQV---LDLSDNRLLSFPDNFFARNGQLRQLHL 354
              |.| :|..|.|..||| ..:|    .:..||:.   |.|:.|.|:....:.......|..|.|
plant   179 --GNLSRLVNLELFSNRLVGKIP----DSIGDLKQLRNLSLASNNLIGEIPSSLGNLSNLVHLVL 237

  Fly   355 QRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLH 419
            ..|||......|:.:|.|||.:....||||.....:|.:|..|....:|.||.|..........|
plant   238 THNQLVGEVPASIGNLIELRVMSFENNSLSGNIPISFANLTKLSIFVLSSNNFTSTFPFDMSIFH 302

  Fly   420 ALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQVLHRLRYLSVQ 484
            .|...|:|.|.|    ||.|  .:||:|:                       |.    |..:.:|
plant   303 NLEYFDVSYNSF----SGPF--PKSLLLI-----------------------PS----LESIYLQ 334

  Fly   485 QNRKLTYLPATLFANTPN---IRELLLAENGLL-QLPTQISGLSRLQRLSVRGNSL-GSLPENIK 544
            :|:   :.....||||.:   :::|:|..|.|. .:|..||.|..|:.|.:..|:. |::|..|.
plant   335 ENQ---FTGPIEFANTSSSTKLQDLILGRNRLHGPIPESISRLLNLEELDISHNNFTGAIPPTIS 396

  Fly   545 ELRQLHYLNILGNEYQCD---CSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLD-SYESI 605
            :|..|.:|::..|..:.:   |      .|..||.....:.....:|.|........|| :..|.
plant   397 KLVNLLHLDLSKNNLEGEVPAC------LWRLNTMVLSHNSFSSFENTSQEEALIEELDLNSNSF 455

  Fly   606 DHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQ-FSEPKMHKLLSTAKL---ECQISGSPVPDII 666
            ...|..:.|:....|.:....:..:.|:|:.:: ||.       |..:|   :...||: :|||.
plant   456 QGPIPYMICKLSSLGFLDLSNNLFSGSIPSCIRNFSG-------SIKELNLGDNNFSGT-LPDIF 512

  Fly   667 WVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLV 731
                                   ||        |.||.:| |.|:         |.|.|
plant   513 -----------------------SK--------ATELVSL-DVSH---------NQLEG------ 530

  Fly   732 ENGSLLVHNISRIDSGLYTCYAFNVMGKASAGLRLYIDPIVFYRVKIGSILFGTALATAFLLLTL 796
                       :....|..|.|..::...|.              ||..| |.:.|.:   |.:|
plant   531 -----------KFPKSLINCKALELVNVESN--------------KIKDI-FPSWLES---LPSL 566

  Fly   797 IVQGLRSCLSRWGICNRFYCCVNRKKKSPRKHQ-------------------------------- 829
            .|..|||        |:||        .|..|:
plant   567 HVLNLRS--------NKFY--------GPLYHRHASIGFQSLRIIDISHNNFSGTLPPYYFSNWK 615

  Fly   830 -IYAMLDSIETYKSQ----------QLERLRENYTQQVHRIRENCAQQVEW----IQSSYTSQAK 879
             :..:.:.::.|.::          ::|.:.:.......|||.: .:.:::    |..:......
plant   616 DMTTLTEEMDQYMTEFWRYADSYYHEMEMVNKGVDMSFERIRRD-FRAIDFSGNKINGNIPESLG 679

  Fly   880 HIREFR--DIGSNHLTTLKDQYYDQVKKVRDYSTGQLSWVRENYVFQRNKI-------------- 928
            :::|.|  ::..|..|::..::...:.|:            |.....|||:
plant   680 YLKELRVLNLSGNAFTSVIPRFLANLTKL------------ETLDISRNKLSGQIPQDLAALSFL 732

  Fly   929 --RKFSAHQVLR--LREGYKYQQQTLNKVLENLPSFY-FEN-CR--------GRCEEDIAE 975
              ..|| |.:|:  :..|.::|:|..:..|:| |..| .|: ||        .:..||::|
plant   733 SYMNFS-HNLLQGPVPRGTQFQRQKCSSFLDN-PGLYGLEDICRDTGALNPTSQLPEDLSE 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_RI	<246..433	CDD:238064	58/192 (30%)
		LRR_8	251..311	CDD:290566	19/61 (31%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..300	CDD:275380	11/24 (46%)
		leucine-rich repeat	301..324	CDD:275380	7/23 (30%)
		LRR_8	325..383	CDD:290566	17/60 (28%)
		leucine-rich repeat	325..348	CDD:275380	5/25 (20%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		LRR_RI	351..>557	CDD:238064	58/210 (28%)
		LRR_8	371..431	CDD:290566	19/59 (32%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	5/22 (23%)
		leucine-rich repeat	421..444	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	18/62 (29%)
		leucine-rich repeat	478..502	CDD:275380	7/23 (30%)
		leucine-rich repeat	503..526	CDD:275380	8/23 (35%)
		Ig	<714..761	CDD:299845	6/46 (13%)
RLP12	NP_177296.2	LRRNT_2	36..80	CDD:285463	1/5 (20%)
		LRR_8	112..170	CDD:290566	22/82 (27%)
		leucine-rich repeat	112..135	CDD:275380	9/36 (25%)
		leucine-rich repeat	136..159	CDD:275380	7/33 (21%)
		LRR_8	159..218	CDD:290566	23/64 (36%)
		leucine-rich repeat	160..183	CDD:275380	11/24 (46%)
		leucine-rich repeat	184..207	CDD:275380	9/26 (35%)
		LRR_RI	198..479	CDD:238064	79/326 (24%)
		LRR_8	206..266	CDD:290566	16/59 (27%)
		leucine-rich repeat	208..231	CDD:275380	4/22 (18%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..279	CDD:275380	8/22 (36%)
		leucine-rich repeat	280..352	CDD:275380	25/107 (23%)
		leucine-rich repeat	304..322	CDD:275380	8/23 (35%)
		LRR_8	351..411	CDD:290566	18/59 (31%)
		leucine-rich repeat	353..376	CDD:275380	8/22 (36%)
		LRR_RI	374..601	CDD:238064	65/332 (20%)
		leucine-rich repeat	377..400	CDD:275380	7/22 (32%)
		leucine-rich repeat	401..422	CDD:275380	5/26 (19%)
		leucine-rich repeat	445..468	CDD:275380	5/22 (23%)
		leucine-rich repeat	469..493	CDD:275380	5/30 (17%)
		leucine-rich repeat	494..517	CDD:275380	9/54 (17%)
		LRR_8	516..576	CDD:290566	24/112 (21%)
		leucine-rich repeat	518..541	CDD:275380	9/49 (18%)
		leucine-rich repeat	542..565	CDD:275380	7/40 (18%)
		leucine-rich repeat	592..616	CDD:275380	0/23 (0%)
		leucine-rich repeat	617..683	CDD:275380	6/66 (9%)
		LRR_8	682..742	CDD:290566	12/72 (17%)
		LRR_4	682..719	CDD:289563	9/48 (19%)
		leucine-rich repeat	684..707	CDD:275380	3/22 (14%)
		leucine-rich repeat	708..729	CDD:275380	4/32 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910