DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and Lingo3

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001103079.1	Gene:	Lingo3 / 690755	RGDID:	1592209	Length:	589	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	147/626 - (23%)
Similarity:	230/626 - (36%)	Gaps:	155/626 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 RLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQRFLGELSELR 278
            ||..:...||...|   :||:|.||:...:..:|..:..|:||.|:.:.:.::.......|..||
  Rat    43 RLTAVPEGIPAETR---MLELSRNRIRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLR 104

  Fly   279 MLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFF 343
            :|.|..|.|..:|..:|.....|..|.||.|:|.:|....||....||.|::.||.|:......|
  Rat   105 VLRLRGNQLKLIPPGVFTHLDSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAF 169

  Fly   344 ARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLT 408
            |....|.:|.|:|..|.|:...||..||.|..|.|...:::.::.:.|:.|..||.|.:  :|..
  Rat   170 AGLLGLAELTLERCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQKLPGLLHLEI--DNWP 232

  Fly   409 LLSSIIFQSLHALR--QLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVD 471
            ||..:...||..|.  .|.::......:|:...::|..|..|.:...||
  Rat   233 LLEEVAPGSLRGLNLTSLSITHTNITAVPAAALRQQAHLTCLNLSHNPI---------------- 281

  Fly   472 PQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQL--PTQISGLSRLQRLSVRGN 534
                              :.:|...|.:...:|||.|| ..||.:  |....||.:::.|::..|
  Rat   282 ------------------SMVPRGSFRDLVRLRELHLA-GALLAVIEPQAFVGLRQIRLLNLSDN 327

  Fly   535 SLGSLPEN-IKELRQLHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTP 598
            .|.:|.|| ...:..|..|.:.||...|||.:.|:.               |.:...|
  Rat   328 LLSTLEENTFHSVNTLETLRVDGNPLACDCRLLWIV---------------QRRKTLN------- 370

  Fly   599 LDSYESIDHQIDALKCQYGYRGDMLR------VLSKLNCSVPTVVQFSEPKMHKLLST----AKL 653
                  .|.::.|.......|||.|.      :.....|..|.:   .|.::..:.:|    .:.
  Rat   371 ------FDGRLPACATPAEVRGDALHNLPDSVLFEYFVCRKPKI---RERRLQHVTATEGDDVRF 426

  Fly   654 ECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWT 718
            .|:..|.|.|.:.||||     :||:      :...|:
  Rat   427 LCRAEGEPAPTVAWVTP-----QHHS------VTAASR--------------------------- 453

  Fly   719 RQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMG-----------------------KA 760
                  ||..|| ..|:|.:.:....|||.|||.|.|..|                       :.
  Rat   454 ------GRARVL-PGGTLAITDTRPQDSGTYTCVASNAGGNDTYFATLTIHPAANRTQSDGHNET 511

  Fly   761 SAGLRLYID-PIVFYRVKIGSILFGTALATAFLLLTLIVQG 800
            ..|:|..:| ..:.....:|.|.|...:...||||.:..:|
  Rat   512 QVGVRFPLDLTTILVSTAMGCITFLGVVLFCFLLLFVWSRG 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	4/13 (31%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_RI	<246..433	CDD:238064	56/188 (30%)
		LRR_8	251..311	CDD:290566	18/59 (31%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_8	325..383	CDD:290566	21/57 (37%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		LRR_RI	351..>557	CDD:238064	50/210 (24%)
		LRR_8	371..431	CDD:290566	16/61 (26%)
		leucine-rich repeat	373..396	CDD:275380	5/22 (23%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..444	CDD:275380	4/24 (17%)
		LRR_8	477..536	CDD:290566	14/60 (23%)
		leucine-rich repeat	478..502	CDD:275380	2/23 (9%)
		leucine-rich repeat	503..526	CDD:275380	10/24 (42%)
		Ig	<714..761	CDD:299845	15/69 (22%)
Lingo3	NP_001103079.1	LRRNT	23..55	CDD:214470	4/11 (36%)
		leucine-rich repeat	34..53	CDD:275380	3/9 (33%)
		LRR	<55..353	CDD:227223	90/337 (27%)
		leucine-rich repeat	55..78	CDD:275380	7/25 (28%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		leucine-rich repeat	103..150	CDD:275380	17/46 (37%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		leucine-rich repeat	175..198	CDD:275380	9/22 (41%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		leucine-rich repeat	223..246	CDD:275380	8/24 (33%)
		LRR_8	246..302	CDD:404697	14/90 (16%)
		leucine-rich repeat	247..270	CDD:275380	3/22 (14%)
		leucine-rich repeat	271..292	CDD:275380	6/54 (11%)
		leucine-rich repeat	295..316	CDD:275380	8/21 (38%)
		leucine-rich repeat	319..342	CDD:275380	6/22 (27%)
		PCC	331..>405	CDD:188093	20/101 (20%)
		Ig	407..489	CDD:416386	28/129 (22%)
		Ig strand A'	413..417	CDD:409353	0/3 (0%)
		Ig strand B	423..432	CDD:409353	1/8 (13%)
		Ig strand C	437..442	CDD:409353	1/4 (25%)
		Ig strand C'	445..447	CDD:409353	1/1 (100%)
		Ig strand D	456..459	CDD:409353	0/2 (0%)
		Ig strand E	462..469	CDD:409353	2/6 (33%)
		Ig strand F	475..483	CDD:409353	5/7 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920