DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and lingo1a

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_005174327.1	Gene:	lingo1a / 564943	ZFINID:	ZDB-GENE-080327-16	Length:	615	Species:	Danio rerio

Alignment Length:	661	Identity:	141/661 - (21%)
Similarity:	218/661 - (32%)	Gaps:	216/661 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 RSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAAD 324
            |.:|..:|:   |..||.|:|:||:|.:..:..|.|....:||.|.|:.|.:|.:....|.....
Zfish    52 RKKLMSVPE---GIPSETRLLDLSKNRIKTINPDEFSAFPQLEELELNENTISAIEPGAFNNLYG 113

  Fly   325 LQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRK 389
            ||.|.|..|:|            :|.||.:            ...|..|.:||:|:|.:.::...
Zfish   114 LQTLGLRSNKL------------KLIQLGV------------FTGLSNLTKLDISENKIVILLDY 154

  Fly   390 AFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETP 454
            .|:.|.:|.:|.|..|:|..:|...|..|.:|.||.|.:.....:|:..|....|||.||:....
Zfish   155 MFQDLYNLRSLEVGDNDLVFISHRAFHGLSSLEQLTLEKCNLTSVPTEAFTHLHSLVTLRLRNLN 219

  Fly   455 IE----------------QFSNWISRYDESLVDPQVLHRLRYLSVQ-QNRKLTYLPATLFANTPN 502
            |.                :.:||  .|.:::. ...|:.|...|:. .|..||.:|.....:...
Zfish   220 INSIRDYSFKRLYRLKVLEIANW--PYLDTMT-TNCLYGLNLTSLTITNANLTSIPYLALRHLVY 281

  Fly   503 IRELLLAEN-----------GLLQL--------------PTQISGLSRLQRLSVRGNSLGSLPEN 542
            :|.|.::.|           .||:|              |....||:.|:.|:|..|.|.:|.|:
Zfish   282 LRFLNMSYNPIQMIEGNRLHDLLRLQELYLVGGRLSVIEPYSFRGLNYLKVLNVSSNFLTTLEES 346

  Fly   543 I-KELRQLHYLNILGNEYQCDCSMYWL--TAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDSYES 604
            : ..:..|..|.:..|...|||.:.|:  ..|..|    ...|.|
Zfish   347 VFHSVGNLETLALHDNPLACDCRLLWVFRRRWRLN----FNRQQP-------------------- 387

  Fly   605 IDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPK-----------------------MHK 646
                                     .||.|..||..|.|                       ..|
Zfish   388 -------------------------TCSSPEFVQGKEFKDFPDILQPNYFTCRKSRIRDRKPQQK 427

  Fly   647 LL---STAKLECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMD 708
            .:   :|....||..|.|.|.|:|::|:.:.:
Zfish   428 FVDEGTTVHFVCQADGDPTPVIMWLSPQKQFI--------------------------------- 459

  Fly   709 ESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMGKASAGLRLYI----- 768
                       ....:||..|. .:|:|.|......|:|.|.|.|.|..|..:|...|::
Zfish   460 -----------TMKTIGRLTVF-PDGTLEVRYAQIQDNGTYGCIASNAGGNDTALAHLHVHSYSP 512

  Fly   769 -------DPIVFYRVKIGSILFGTALATA---FLLLTLIVQGLRSCLSRWGICNRFYCCVN---- 819
                   ..:.|...:..........||.   |.:.|||:......:|..|:.  .:|.|.
Zfish   513 DWPNQPNKTLAFISNQPNDNSINETRATVPFPFDIKTLIIATTMGFISFLGVV--LFCLVLLFLW 575

  Fly   820 RKKKSPRKHQI 830
            .:.|...||.|
Zfish   576 SRGKGNSKHNI 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	49/172 (28%)
		LRR_8	251..311	CDD:290566	18/50 (36%)
		leucine-rich repeat	253..276	CDD:275380	4/15 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	15/57 (26%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		LRR_RI	351..>557	CDD:238064	58/248 (23%)
		LRR_8	371..431	CDD:290566	19/59 (32%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..444	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	19/84 (23%)
		leucine-rich repeat	478..502	CDD:275380	6/24 (25%)
		leucine-rich repeat	503..526	CDD:275380	9/47 (19%)
		Ig	<714..761	CDD:299845	13/46 (28%)
lingo1a	XP_005174327.1	LRRNT	34..68	CDD:214470	6/18 (33%)
		LRR_RI	<55..231	CDD:238064	56/202 (28%)
		leucine-rich repeat	66..89	CDD:275380	7/22 (32%)
		LRR_8	88..148	CDD:290566	22/83 (27%)
		leucine-rich repeat	90..113	CDD:275380	7/22 (32%)
		leucine-rich repeat	114..137	CDD:275380	10/46 (22%)
		LRR_8	136..196	CDD:290566	19/59 (32%)
		leucine-rich repeat	138..185	CDD:275380	15/46 (33%)
		LRR_8	184..241	CDD:290566	12/56 (21%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..257	CDD:275380	9/49 (18%)
		leucine-rich repeat	234..256	CDD:275380	4/24 (17%)
		LRR_8	257..316	CDD:290566	11/58 (19%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		leucine-rich repeat	282..305	CDD:275380	4/22 (18%)
		LRR_8	305..364	CDD:290566	14/58 (24%)
		leucine-rich repeat	306..329	CDD:275380	4/22 (18%)
		leucine-rich repeat	330..350	CDD:275380	7/19 (37%)
		TPKR_C2	362..>398	CDD:301599	14/84 (17%)
		I-set	421..507	CDD:254352	25/130 (19%)
		Ig	432..507	CDD:299845	24/119 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920