DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and lingo1b

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001004576.1	Gene:	lingo1b / 447837	ZFINID:	ZDB-GENE-040912-136	Length:	622	Species:	Danio rerio

Alignment Length:	570	Identity:	134/570 - (23%)
Similarity:	211/570 - (37%)	Gaps:	131/570 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 RLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQRFLGELSELR 278
            :|..|...||:..|   :|::|.|||...:........||::|.|:.:.::.:.......|..||
Zfish    63 KLITLPEGIPIDTR---LLDLSKNRLKAINPEEFLNYPQLEDLQLNENIISVIEPGAFSNLLGLR 124

  Fly   279 MLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFF 343
            .|.|..|.|..:...:|.|...|.||.:|.|::.:|...:||...:|:.|::.||.|:......|
Zfish   125 TLGLRNNNLKLIQLGVFTGLSNLTRLDISENKIVILLDYMFQELYNLKELEVGDNDLVFISHRAF 189

  Fly   344 ARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLT 408
            .....|.||.::|..|.|:...:...|..|..|.|...:::||...:|..|..|..|.::  |..
Zfish   190 HGLSSLEQLTMERCNLTSVPTEAFSHLHNLLTLKLRHLNVNVIRDFSFRRLYRLKILEIA--NWP 252

  Fly   409 LLSSIIFQSLHALR--QLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVD 471
            ||.|:..:|||.|.  .|.::......:|....|....|....:...|||            :|:
Zfish   253 LLESLTAKSLHGLNITTLSITNCNLTAVPYVAIQHLVYLRFFNLSFNPIE------------VVE 305

  Fly   472 PQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQL-PTQISGLSRLQRLSVRGNS 535
            ...:|                      |...::...|....|:.: |....||:.|:.|:|..||
Zfish   306 GNKMH----------------------NLLRLQAFHLVGGRLVSIEPYSFKGLNYLRVLNVSSNS 348

  Fly   536 LGSLPEN-IKELRQLHYLNILGNEYQCDCSMYWL--TAWLANTSTSLRHQMPQAQNHSNGSTNQT 597
            |.:|.|: ...:..|..|.:..|...|||.:.|:  ..|..|    ...|.|..         :|
Zfish   349 LSTLEESAFHSVGNLETLALHDNPLACDCRLLWVFRRRWRLN----FNRQQPSC---------ET 400

  Fly   598 P--LDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLL-------STAKL 653
            |  |...|..|.. |.|...|            ..|      |.|:.:.||.:       :|.:.
Zfish   401 PEFLQGKEFKDFP-DVLPPNY------------FTC------QKSKIRDHKAIHRFVDEGTTVQF 446

  Fly   654 ECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWT 718
            .||..|.|.|.|:|.:|:.:             .|.:|.
Zfish   447 PCQADGDPTPMIMWQSPKKQ-------------FITTKS-------------------------- 472

  Fly   719 RQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMGKASAGLRLYI 768
                 :||..|.:: |:|.|......|:|.|||:|.|..|..:....|::
Zfish   473 -----IGRLSVSLD-GTLEVRYAQIQDNGTYTCFAVNAGGNDTRLAHLHV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	4/13 (31%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_RI	<246..433	CDD:238064	52/188 (28%)
		LRR_8	251..311	CDD:290566	18/59 (31%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		LRR_8	325..383	CDD:290566	16/57 (28%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		LRR_RI	351..>557	CDD:238064	48/209 (23%)
		LRR_8	371..431	CDD:290566	18/61 (30%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..444	CDD:275380	4/24 (17%)
		LRR_8	477..536	CDD:290566	10/59 (17%)
		leucine-rich repeat	478..502	CDD:275380	1/23 (4%)
		leucine-rich repeat	503..526	CDD:275380	5/23 (22%)
		Ig	<714..761	CDD:299845	14/46 (30%)
lingo1b	NP_001004576.1	LRRNT	43..77	CDD:214470	5/16 (31%)
		LRR 1	74..95		6/23 (26%)
		leucine-rich repeat	75..98	CDD:275380	6/25 (24%)
		LRR_8	76..133	CDD:290566	16/59 (27%)
		LRR_RI	78..>315	CDD:238064	66/272 (24%)
		LRR 2	98..119		4/20 (20%)
		leucine-rich repeat	99..146	CDD:275380	12/46 (26%)
		LRR 3	122..143		7/20 (35%)
		LRR_8	130..181	CDD:290566	16/50 (32%)
		LRR 4	146..167		7/20 (35%)
		leucine-rich repeat	147..170	CDD:275380	8/22 (36%)
		LRR_8	170..226	CDD:290566	16/55 (29%)
		LRR 5	170..191		6/20 (30%)
		leucine-rich repeat	171..194	CDD:275380	6/22 (27%)
		LRR 6	194..215		6/20 (30%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		LRR 7	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		leucine-rich repeat	243..290	CDD:275380	13/48 (27%)
		LRR_8	266..325	CDD:290566	11/92 (12%)
		LRR 8	266..287		2/20 (10%)
		LRR 9	290..311		6/54 (11%)
		leucine-rich repeat	291..338	CDD:275380	12/80 (15%)
		LRR_8	314..373	CDD:290566	16/58 (28%)
		LRR 10	314..335		3/20 (15%)
		LRR 11	338..359		8/20 (40%)
		leucine-rich repeat	339..362	CDD:275380	8/22 (36%)
		TPKR_C2	371..424	CDD:301599	18/84 (21%)
		IG_like	438..516	CDD:214653	26/122 (21%)
		Ig	441..516	CDD:299845	26/119 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920