DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and kek6

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	961	Identity:	177/961 - (18%)
Similarity:	326/961 - (33%)	Gaps:	315/961 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 SGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFFARNG--QLRQLHLQRNQLKSIGKHSLYS 369
            |..:|:.:|..|   :.:||||.|:||.:.......|:..|  .|::::|::::::.|.|.|..:
  Fly    56 SSLQLTTIPNTL---STELQVLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRN 117

  Fly   370 LRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQL 434
            |:.|.::|||.|.|.::|:..|...|.|..|.::||.|..|::..|..|..||.||:
  Fly   118 LKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDM-------- 174

  Fly   435 PSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQVLHRLRYLSVQQNRKLTYLPATLFAN 499
                    ...::..||
  Fly   175 --------HDCLISYID------------------------------------------------ 183

  Fly   500 TPNIRELLLAENGLLQLPTQISGLSRLQRLSVRGNSLGSLPENI-KELRQLHYLNILGNEYQCDC 563
                             |..::.|:.|:.|:::.|.|.||.|.: :.:..|..|::..|.:||:|
  Fly   184 -----------------PMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKTLSLEENPWQCNC 231

  Fly   564 SMYWLTAWLAN---TSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRV 625
            .:.....|..|   :|.||..:.|.||...          :::|:|.::
  Fly   232 KLRKFRGWYVNSRLSSVSLVCKGPPAQKDR----------TWDSVDDEL---------------- 270

  Fly   626 LSKLNCSVPTVVQFSEPKMHK--LLSTAKLECQISGSPVPDIIWVTPRNKILRHHADPDKRPIII 688
               ..|. |.|..|:..::..  :.|.....|.:.|.|:|::.|.. ..|||      |...::.
  Fly   271 ---FGCP-PRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWEL-NGKIL------DNDNVLF 324

  Fly   689 DSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYA 753
            :|                  ||......|:                :|.|.|::.:|:|.|.|..
  Fly   325 ES------------------ESIASDKLWS----------------NLTVFNVTSLDAGTYACTG 355

  Fly   754 FNVMGKASAGLRLYIDPIV------------FYRVKIGSILFGTALATAFLLLTLIVQGLRSCLS 806
            .|.:|..:..:.:|:..||            ::.:.:|  :||    |.|||:::
  Fly   356 SNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLIMG--IFG----TVFLLISI---------- 404

  Fly   807 RWGICNRFYCCVNRKKKSPRKHQIYAMLDSIETYKSQQLERLRENYTQQVHRIRENCAQQVEWIQ 871
                  .|..|:.::.....:|...|.:.|..::..|:.:.|..:.|...:...::..     |.
  Fly   405 ------SFVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYG-----ID 458

  Fly   872 SSYTSQAKHIREFRDIGSNHLTTLKDQYYDQVKKVRDYSTGQLSWVRENYVFQRNKIRKFSAHQV 936
            :..||...:..:...:|.|.:         ::..|..:..|.:       :.|:..       |.
  Fly   459 NQPTSIGMNKGDSAGMGFNQI---------EIHAVESHRHGSM-------LVQQQP-------QQ 500

  Fly   937 LRLREGYKYQQQTLNKVLENLPSFYFENCRGRCEEDIAEDIDCYFKGQMDFGDSKELHIQKIKAR 1001
            .::..|...:||.:.                      .:|..|   |.|....|...|.....|:
  Fly   501 QQVAGGGGMRQQLMQ----------------------VKDSTC---GMMSVPTSMAGHAHSHPAQ 540

  Fly  1002 LSANYSASKASLYYTPPDDDLLHSSQLNLQNSP-------IHINYIDENLDQQKQLEHDFKMEPQ 1059
            :|..:..: ..::..||:      ...|:..:|       |.::...:.||..     |..|.|.
  Fly   541 ISEEFPLN-VGVFPPPPE------FCSNIVPNPAFGGNIFIRVSVTQDMLDGA-----DLNMYPD 593

  Fly  1060 LLLYNASMLYMNPEGASS----SGQAAAL----AAAGALSQFISVEDNNQE-------QEMQPLR 1109
            ||.....|..:...||.:    .||.|.|    |..|.|.:..|::...|:       |:.|..:
  Fly   594 LLNIPKRMQDVQESGAGAVAVPEGQFATLPRHTARRGILKKDTSLQQQQQQHQQQHQHQQQQQQQ 658

  Fly  1110 KISGKPLGMPELKDLNDVKTSKSCPAIYKVSKQRDGSTLHELQKEGEAPYQM-LRINPVE--TTS 1171
            :|        :.:....::.......:|    ..|....:.|:..|..|:|. ...|.:|  ...
  Fly   659 QI--------QQQQHQQLQQQHQPSGLY----THDEIVTYNLEASGYDPHQSGYHSNAMELPPPP 711

  Fly  1172 LTSTVAPVMQARTEKLNIILDECGTASLCKAEQEGDAGNSETPPSESSCES 1222
            ....|..|:|......|    .|.:..            :..||..|:|:|
  Fly   712 PPPAVTAVVQCHHPSPN----NCASCI------------NNAPPPPSACQS 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	40/127 (31%)
		LRR_8	251..311	CDD:290566	1/3 (33%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		leucine-rich repeat	301..324	CDD:275380	4/16 (25%)
		LRR_8	325..383	CDD:290566	20/59 (34%)
		leucine-rich repeat	325..348	CDD:275380	9/24 (38%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		LRR_RI	351..>557	CDD:238064	39/206 (19%)
		LRR_8	371..431	CDD:290566	21/59 (36%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..444	CDD:275380	4/22 (18%)
		LRR_8	477..536	CDD:290566	5/58 (9%)
		leucine-rich repeat	478..502	CDD:275380	0/23 (0%)
		leucine-rich repeat	503..526	CDD:275380	2/22 (9%)
		Ig	<714..761	CDD:299845	10/46 (22%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	9/24 (38%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_4	144..186	CDD:289563	15/122 (12%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..216	CDD:275380	15/127 (12%)
		LRRCT	225..274	CDD:214507	14/77 (18%)
		Ig	295..367	CDD:143165	22/112 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940