DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and CG7800

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	141/601 - (23%)
Similarity:	221/601 - (36%)	Gaps:	178/601 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 MLAHVPADRSNPLKLPQLESLREFSWQSSELKDETLMELFTRQPRSFEYMERLNLAENRLE-CLH 219
            :||.|.|     |..|.||          :..:::...|..|. |:|...:...|.|..:: |
  Fly     8 LLASVSA-----LGRPDLE----------DYCNDSYCHLLGRS-RTFSDKKATKLTEFHMDSC-- 54

  Fly   220 WAIPLAVRRVKVLEMSGN----RLSNC-----SLLNLQYMKQLQELHLDRSELTYLPQRFLGELS 275
                    ..|||::..|    .|.||     ::.:|..:..|..|.|.|..|..|......:..
  Fly    55 --------EKKVLKLMPNLRTLELENCDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWP 111

  Fly   276 ELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPD 340
            .:::|.|..|.:|.|..:.|.|..:|..|.|.||.:..||:.:||...:|..||||.||:.:..:
  Fly   112 NMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIETLHE 176

  Fly   341 NFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQ----NSLS-------VIDRKAFESL 394
            |.|....:|..|.|..|.|..|...||.||..||.||:|.    ..||       ::|....:.|
  Fly   177 NIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSNCGPLPDLSLPGAHTLILDNSGVQRL 241

  Fly   395 DHLLA---LNVSGNNLTLL-----SSIIFQSLHA-----------------LRQLDLSRN----- 429
            |.|.:   |....|::|.:     ||:|...||:                 |::||||.|
  Fly   242 DILGSVHKLQARKNHITEIKLPDKSSVIELDLHSNLLTATDIPKLLTGMWRLQRLDLSENIIGIY 306

  Fly   430 ---------QFKQLPSGLFQRQRSLVLLRID-ETPIEQFSNWISRYDESLVDPQVLHRLRYLSVQ 484
                     :...||:.::....:..|.|:. ::||.    |              .||.:|...
  Fly   307 AAAGSDNTSELFILPNLMYMNLSANRLTRLHFDSPIP----W--------------ERLTHLDAS 353

  Fly   485 QNRKLTYLPATL----------------FANT---------PNIRELLLAENGLLQLPTQISGLS 524
            .||  .|.||.:                :.|.         |:::|:.|.:|..     |..|..
  Fly   354 YNR--IYAPAKVGIDEAFNLQSLHLEGNYINNFELTPWKPHPSLKEVALYDNKF-----QPKGYK 411

  Fly   525 RLQRLSVRGNSLGSLPENIKELRQLHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNH 589
            .:.:..   |.:|   .|:.|..|....|                    ||:.:.:..:|.|::.
  Fly   412 NITKFF---NEIG---VNVLEKTQYSQSN--------------------NTTPTCKPCIPDARDF 450

  Fly   590 S---NGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVV-QFSEPKMHKLLST 650
            .   :..||||       ||.:::.|. ...|:.::..||..::..|...| .|...|:.:|...
  Fly   451 PTSISADTNQT-------IDTKVNPLS-NDTYQWNVWNVLMLVSLIVSLFVNSFLIVKLIRLRGR 507

  Fly   651 AKLECQISGSPVPDII 666
            .:.   ...|.||.||
  Fly   508 NQF---TQSSSVPAII 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	3/22 (14%)
		leucine-rich repeat	229..252	CDD:275380	8/31 (26%)
		LRR_RI	<246..433	CDD:238064	67/236 (28%)
		LRR_8	251..311	CDD:290566	18/59 (31%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_8	325..383	CDD:290566	24/61 (39%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		leucine-rich repeat	349..372	CDD:275380	10/22 (45%)
		LRR_RI	351..>557	CDD:238064	62/281 (22%)
		LRR_8	371..431	CDD:290566	25/109 (23%)
		leucine-rich repeat	373..396	CDD:275380	9/33 (27%)
		leucine-rich repeat	397..420	CDD:275380	8/30 (27%)
		leucine-rich repeat	421..444	CDD:275380	8/36 (22%)
		LRR_8	477..536	CDD:290566	16/83 (19%)
		leucine-rich repeat	478..502	CDD:275380	8/48 (17%)
		leucine-rich repeat	503..526	CDD:275380	5/22 (23%)
		Ig	<714..761	CDD:299845
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	6/27 (22%)
		leucine-rich repeat	65..85	CDD:275380	4/19 (21%)
		LRR_8	87..147	CDD:290566	18/59 (31%)
		leucine-rich repeat	89..112	CDD:275380	6/22 (27%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR_RI	<131..334	CDD:238064	57/202 (28%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		LRR_8	140..195	CDD:290566	21/54 (39%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		leucine-rich repeat	185..208	CDD:275380	10/22 (45%)
		leucine-rich repeat	209..246	CDD:275380	11/36 (31%)
		leucine-rich repeat	247..267	CDD:275380	3/19 (16%)
		leucine-rich repeat	268..292	CDD:275380	3/23 (13%)
		leucine-rich repeat	293..322	CDD:275380	7/28 (25%)
		leucine-rich repeat	395..406	CDD:275378	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930