DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG16974 and Toll-6

DIOPT Version :9

Sequence 1:NP_001246018.1 Gene:CG16974 / 34713 FlyBaseID:FBgn0032479 Length:1257 Species:Drosophila melanogaster
Sequence 2:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:1514 Identity:294/1514 - (19%)
Similarity:484/1514 - (31%) Gaps:577/1514 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 DEGLWLDAADAGSESVEVEEHELPSVGHVDPTGNVFKLNCEHVDLRRVNQE-------------- 141
            |..|: ||.|        :.|.:|:.|...|.   ..|.|   :||.||.|              
  Fly    71 DPSLY-DAPD--------DCHFMPAAGLDQPE---IALTC---NLRTVNSEFDTTNFSVIPAEHT 120

  Fly   142 ----------------LLSQRSSH-INYNQLMLAHVPADRSNPLKLPQLESLREFS-------WQ 182
                            |.:|..:| :...||.:.:....|.....|..||.||..:       |.
  Fly   121 IALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWP 185

  Fly   183 SSELKDETLMELFTRQPRSFEYMERLNLAENRLECLHWAIP----LAVRRVKVLEMSGNRL---- 239
            :...:.|......||:      :|||:|:.|.:    |::|    ..:..:..|.||.|||    
  Fly   186 ALNFEIEADAFSVTRR------LERLDLSSNNI----WSLPDNIFCTLSELSALNMSENRLQDVN 240

  Fly   240 --------------------------------SNCSLLNLQY------------------MKQLQ 254
                                            ::|| |:|:|                  :::|:
  Fly   241 ELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCS-LDLEYLDVSHNDFVVLPANGFGTLRRLR 304

  Fly   255 ELHLDRSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALK-LERLYLSGNRLSVLPFML 318
            .|.::.:.::.:..:.|..|..|::||||.|.:..||.::|....| ::.:||..|.:|||...|
  Fly   305 VLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQL 369

  Fly   319 FQTAADLQVLDLSDNRLLS-------------------------------FPDNF---------- 342
            |.....||.||||.|::.|                               |.|.:          
  Fly   370 FSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHN 434

  Fly   343 -------------------------------FARNG--------------------------QLR 350
                                           :|.||                          .|:
  Fly   435 QLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQ 499

  Fly   351 QLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIF 415
            .|:|..||||:: ..:|.::|.||.:||.:|.::|::..||:.|.:|..|.:.||.|..::...|
  Fly   500 DLNLNGNQLKTV-PLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTF 563

  Fly   416 QSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQ----FSN-----WISRYD---ES 468
            :.|..|:.|:|:||:...:..|.|:...|:..:|:|...:..    |||     |::..|   ||
  Fly   564 RDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLES 628

  Fly   469 LVDPQVLHRLRYLSVQQNR--------------KLTYLPATLF-------ANTPNIRELLLAENG 512
            .....|...|::|.:.:||              ||..|..:..       ::.||..|||...:.
  Fly   629 FDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDN 693

  Fly   513 LLQL--PTQISGLSRLQRLSVRGNSLGSLPENIKELRQL----------HYLNILGNEYQCDCSM 565
            |:..  |......:.|.|:.:..|.:.:|  :||.||.|          .|:.  ||.:.|||::
  Fly   694 LITTVDPDTFMHKTNLTRVDLYANQITTL--DIKSLRILPVWEHRALPEFYIG--GNPFTCDCNI 754

  Fly   566 YWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLN 630
            .||                |..||.........:|        ::.:.|:.        :.::..
  Fly   755 DWL----------------QKINHITSRQYPRIMD--------LETIYCKL--------LNNRER 787

  Fly   631 CSVPTVVQFSEPKMHKLLSTAKLE----CQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSK 691
            ..:|.:.  :|||  ..|.|.|..    |........|.....|.|....|  |......|::..
  Fly   788 AYIPLIE--AEPK--HFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFH--DQTWSTNIVECS 846

  Fly   692 EDAHQPPSAQELAALMD--ESYIQSLNWTR--QNSLVGRR--VVLVENGSLLVHNISRIDSGLYT 750
            ..|:   |.......||  |.||...|:..  .:|.:||:  .||..|.|.:.|..:...|||  
  Fly   847 GAAY---SEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGL-- 906

  Fly   751 CYAFNVMGKASAGLRLYIDPIVFYRVKIGSILFGTALATAFLLLTLIVQGLRSCLSRWGICNRFY 815
                    |....|.|..:.|:                        .::|           |.|:
  Fly   907 --------KRLLILHLEDNHII------------------------SLEG-----------NEFH 928

  Fly   816 CCVNRKKKSPRKHQIYAMLDSIETYKSQQLERLRENYTQQVHRIRENCAQQVE-W---------- 869
            ...|.:       ::|...:.|.:..:...:.||:   .:|.|:..|.....| |          
  Fly   929 NLENLR-------ELYLQSNKIASIANGSFQMLRK---LEVLRLDGNRLMHFEVWQLSANPYLVE 983

  Fly   870 ---IQSSYTSQAKHIREFRDIGSNHLTTLKDQYYDQVKKVRDYSTGQLSWVRENYVFQRNKIRKF 931
               ..:.::.:..::..||    |:|....::..|         ..::|.:..|           
  Fly   984 ISLADNQWSCECGYLARFR----NYLGQSSEKIID---------ASRVSCIYNN----------- 1024

  Fly   932 SAHQVLR--------LREGYKYQQQTLNKVLENLPSFYFENCRGRCEEDIAEDIDCYFKGQMDFG 988
             |..|||        ||:|..:...| |::...||......|.......:...:.||        
  Fly  1025 -ATSVLREKNGTKCTLRDGVAHYMHT-NEIEGLLPLLLVATCAFVAFFGLIFGLFCY-------- 1079

  Fly   989 DSKELHIQKIKARLSANYSASKASLYYTPPDDDLLHSSQLN-------LQNSPIHINYIDENLDQ 1046
             ..||.|.........|:      .|.:|...|.|...:.|       ||:.    :::::.|.|
  Fly  1080 -RHELKIWAHSTNCLMNF------CYKSPRFVDQLDKERPNDAYFAYSLQDE----HFVNQILAQ 1133

  Fly  1047 QKQLEHDFKMEPQLLLYNASMLYMNPEGASSSGQAAALAAAGALSQFISVEDNNQEQEMQPLRKI 1111
              .||:|       :.|...:.|.: ...::....|.:.||.:..||:.|...|           
  Fly  1134 --TLEND-------IGYRLCLHYRD-VNINAYITDALIEAAESAKQFVLVLSKN----------- 1177

  Fly  1112 SGKPLGMPELKDLNDVKTSKSCPAIY-KVSKQRDGSTLHELQKE---------GEAP-------- 1158
                                   .:| :.|:....|.||||.|.         |:.|        
  Fly  1178 -----------------------FLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDM 1219

  Fly  1159 -----------------YQMLRINPVETTSLTSTVAPVMQARTEKLNIILDEC-----GTASLCK 1201
                             :|.||:           ..|:...|......::..|     .:.::..
  Fly  1220 RHYLRTSTCIEWDDKKFWQKLRL-----------ALPLPNGRGNNNKRVVSGCLSGRTPSVNMYA 1273

  Fly  1202 AEQEGDAGNSET--PPSE--SSCESN-------------------------SLAASC--GDVCQV 1235
            ...|..|||...  |||.  :.|.||                         :.||:|  ..:.|:
  Fly  1274 TSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQL 1338

  Fly  1236 SSKLANDASLPSTPPKPDH 1254
            |.|...|.|:.......:|
  Fly  1339 SKKQQRDLSVAGMAKTLEH 1357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16974NP_001246018.1 leucine-rich repeat 206..228 CDD:275380 7/25 (28%)
leucine-rich repeat 229..252 CDD:275380 11/76 (14%)
LRR_RI <246..433 CDD:238064 67/303 (22%)
LRR_8 251..311 CDD:290566 17/60 (28%)
leucine-rich repeat 253..276 CDD:275380 4/22 (18%)
leucine-rich repeat 277..300 CDD:275380 9/22 (41%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
LRR_8 325..383 CDD:290566 27/155 (17%)
leucine-rich repeat 325..348 CDD:275380 13/120 (11%)
leucine-rich repeat 349..372 CDD:275380 8/22 (36%)
LRR_RI 351..>557 CDD:238064 66/250 (26%)
LRR_8 371..431 CDD:290566 22/59 (37%)
leucine-rich repeat 373..396 CDD:275380 9/22 (41%)
leucine-rich repeat 397..420 CDD:275380 7/22 (32%)
leucine-rich repeat 421..444 CDD:275380 7/22 (32%)
LRR_8 477..536 CDD:290566 17/81 (21%)
leucine-rich repeat 478..502 CDD:275380 7/44 (16%)
leucine-rich repeat 503..526 CDD:275380 5/24 (21%)
Ig <714..761 CDD:299845 13/50 (26%)
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 5/22 (23%)
LRR_8 171..236 CDD:290566 17/74 (23%)
leucine-rich repeat 172..201 CDD:275380 5/28 (18%)
leucine-rich repeat 202..278 CDD:275380 15/80 (19%)
leucine-rich repeat 229..249 CDD:275380 6/19 (32%)
LRR_RI 278..468 CDD:238064 34/189 (18%)
leucine-rich repeat 279..302 CDD:275380 2/22 (9%)
LRR_8 301..386 CDD:290566 29/84 (35%)
leucine-rich repeat 303..326 CDD:275380 4/22 (18%)
leucine-rich repeat 327..350 CDD:275380 9/22 (41%)
LRR 350..729 CDD:227223 86/381 (23%)
leucine-rich repeat 352..375 CDD:275380 8/22 (36%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 45/225 (20%)
leucine-rich repeat 402..425 CDD:275380 2/22 (9%)
leucine-rich repeat 426..449 CDD:275380 0/22 (0%)
leucine-rich repeat 450..473 CDD:275380 3/22 (14%)
leucine-rich repeat 474..497 CDD:275380 0/22 (0%)
leucine-rich repeat 498..518 CDD:275380 8/20 (40%)
leucine-rich repeat 521..544 CDD:275380 9/22 (41%)
leucine-rich repeat 545..566 CDD:275380 6/20 (30%)
leucine-rich repeat 569..592 CDD:275380 7/22 (32%)
leucine-rich repeat 593..615 CDD:275380 5/21 (24%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 4/23 (17%)
leucine-rich repeat 663..684 CDD:275380 3/20 (15%)
leucine-rich repeat 685..708 CDD:275380 5/22 (23%)
leucine-rich repeat 709..728 CDD:275380 6/20 (30%)
LRR_8 883..943 CDD:290566 17/111 (15%)
leucine-rich repeat 885..908 CDD:275380 8/32 (25%)
leucine-rich repeat 909..932 CDD:275380 6/57 (11%)
LRR_8 932..990 CDD:290566 10/67 (15%)
leucine-rich repeat 933..956 CDD:275380 3/29 (10%)
TIR 1114..1247 CDD:214587 30/191 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453819
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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