DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and CG32055

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	145/654 - (22%)
Similarity:	262/654 - (40%)	Gaps:	169/654 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAISKISLILCALFVG--LKAAAAISGDSTHC--LATYSSAEAYLAQIPQQHRPQIRPRIRTWQ 61
            |:|:..::|:|.:...|  |:....:...|..|  :.::.....|:.              :.|:
  Fly     1 MQALQVLALLLLSGVFGKDLQECEDLGNGSYLCREIESFEQLNRYVG--------------KNWK 51

  Fly    62 ------EHEFSLLGYKFHLPFVGHAVDSDLDDSD----SDEGLW-------LDAADAGSESVEVE 109
                  ||..........||.:...:..||.:|.    .::||.       |:...|..:.::.|
  Fly    52 SVKVVNEHTGIERAEDGELPGLSTLLQLDLSESGGVTLGEKGLQDFKALQKLNLTHAQLDELKSE 116

  Fly   110 EHELPSVGHVDPTGNVFKLNCEHVDLRRVNQELLSQRSS--HINYNQLMLAHVPADRSNPLKLPQ 172
            :...||        .:...:..:.|:..:..:|:|...:  :.|:::.::|.:     .|.....
  Fly   117 QFPNPS--------EMINFDVSYNDILAITTKLMSGFGNLVYANFSENLIAVI-----EPNAFRH 168

  Fly   173 LESLREFSWQSSELKDETLMELFTRQPRSFEYMERLNLAENRLECLHWAIPLAVRRVKVLEMSGN 237
            :::||             .::|.|      .|.|.:.|.||             ..::.|.:|.|
  Fly   169 MKNLR-------------FLDLTT------NYQENITLGEN-------------ANLRFLSISNN 201

  Fly   238 RLSNCSLLNLQYMKQLQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKLE 302
            .|.:....:|:.:.:|:||||..:.|.:|.......|..||:||:|.|.|.|:.|.:|:...::
  Fly   202 NLRDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLFEIKRTLFMAPGEI- 265

  Fly   303 RLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSL 367
                                |.|::||.|.|.:....|:.|.|
  Fly   266 --------------------APLELLDYSSNIVKVLDDSVFCR---------------------- 288

  Fly   368 YSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFK 432
              |::||.|:|..|.::.|..:||..|..|..|::.||.:::|...:|.:|.||.:||||:|..:
  Fly   289 --LKKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQ 351

  Fly   433 QLPSGLFQRQ--RSLVLLRIDETPIEQFSNWISRYDESLVDPQVLHRLRY---LSVQQNRKLTYL 492
            :|...:|..:  |.|:.|.:.       :|:|:.     :.|..|..:.:   |.:::|| |..|
  Fly   352 KLGLRVFGERILRKLIYLDLS-------NNYIAD-----LHPLALSSMPFIKELRLRRNR-LVSL 403

  Fly   493 PATLFANTPNIRELLLAENGLLQLPTQI-SGLSRLQRLSVRGNSLGSLPE--NIKELRQLHYLNI 554
            ...:||....::.|.:.||.|.::..:| ..|.||..|.:..|.|..||:  :.:.|.||..:.:
  Fly   404 DLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNNRLTFLPDLKSSQNLLQLRNITL 468

  Fly   555 LGNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNHSNGS--TNQTPLD----------------S 601
            .||.:||.| :..:|:||.....|  :..|.:...|...  ...||:|                |
  Fly   469 EGNPWQCLC-LDEITSWLNGRHVS--YARPSSAYFSGRKPLCVVTPMDKCLRDLQETKAQGIVES 530

  Fly   602 YESI 605
            ||.|
  Fly   531 YEKI 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	4/21 (19%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_RI	<246..433	CDD:238064	52/186 (28%)
		LRR_8	251..311	CDD:290566	18/59 (31%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		leucine-rich repeat	301..324	CDD:275380	0/22 (0%)
		LRR_8	325..383	CDD:290566	14/57 (25%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	1/22 (5%)
		LRR_RI	351..>557	CDD:238064	56/213 (26%)
		LRR_8	371..431	CDD:290566	23/59 (39%)
		leucine-rich repeat	373..396	CDD:275380	9/22 (41%)
		leucine-rich repeat	397..420	CDD:275380	7/22 (32%)
		leucine-rich repeat	421..444	CDD:275380	8/24 (33%)
		LRR_8	477..536	CDD:290566	17/62 (27%)
		leucine-rich repeat	478..502	CDD:275380	7/26 (27%)
		leucine-rich repeat	503..526	CDD:275380	6/23 (26%)
		Ig	<714..761	CDD:299845
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	5/22 (23%)
		leucine-rich repeat	100..123	CDD:275380	5/30 (17%)
		LRR_8	128..180	CDD:290566	10/75 (13%)
		leucine-rich repeat	128..147	CDD:275380	3/18 (17%)
		leucine-rich repeat	148..171	CDD:275380	3/27 (11%)
		leucine-rich repeat	172..192	CDD:275380	9/51 (18%)
		LRR_RI	<187..400	CDD:238064	71/283 (25%)
		LRR_8	192..251	CDD:290566	19/58 (33%)
		leucine-rich repeat	193..216	CDD:275380	5/22 (23%)
		leucine-rich repeat	217..240	CDD:275380	8/22 (36%)
		leucine-rich repeat	241..267	CDD:275380	10/46 (22%)
		leucine-rich repeat	268..291	CDD:275380	9/46 (20%)
		LRR_8	290..350	CDD:290566	23/59 (39%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		leucine-rich repeat	316..339	CDD:275380	7/22 (32%)
		LRR_8	340..400	CDD:290566	18/72 (25%)
		leucine-rich repeat	340..365	CDD:275380	8/24 (33%)
		leucine-rich repeat	366..389	CDD:275380	6/34 (18%)
		leucine-rich repeat	390..413	CDD:275380	7/23 (30%)
		LRR_8	391..448	CDD:290566	17/57 (30%)
		leucine-rich repeat	414..437	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840