DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and CG6749

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	137/530 - (25%)
Similarity:	208/530 - (39%)	Gaps:	129/530 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LPSVGHVDPTGNVF--KLNCEHVDLRRVNQELLSQRSSHINYNQLMLAHVPADRSNPLKLPQLES 175
            |...|.||..||.|  :...:.:|......||| .|....|..:|:.|:...:......||.:..
  Fly   111 LSGCGLVDIRGNHFAPESALQRIDFSHNQMELL-DRDFFGNLRKLIYANFSHNALKQCDLPHMPL 174

  Fly   176 LREFSWQSSELKDET------LMELFTRQPRSFEYMERLNLAENRLECLHWAIPLAVRRVKVLEM 234
            |.......:.|.:.|      |.||....      .:.:.|..|....||..:.        |::
  Fly   175 LNRLELGHNRLVNATFGVCPQLQELILND------NQLIQLDVNAFRGLHGLLE--------LQL 225

  Fly   235 SGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGA- 298
            ||||||:..|...|                        .|::||.||||||.|..|..::| ||
  Fly   226 SGNRLSSIGLETFQ------------------------PLAQLRKLNLSQNALDALRPNVF-GAV 265

  Fly   299 ----LKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQL 359
                |.|::|.|||||:.:|....|:..|.||:||:|.|.:.|.....|...|.||:|:||.|.:
  Fly   266 QNFVLHLQQLDLSGNRIRLLFDNQFRVLARLQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAI 330

  Fly   360 KSIGKHSLYSLRELRQLDLSQNSLSVIDRKAF--ESLDHLLALNVSGNNLTLLSSIIFQSLHALR 422
            ..|...:..:|..|..||||.|:|..::.:.|  .:|..:..||::||.:..|..:.|.||..|.
  Fly   331 LEIKPATFAALLNLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLE 395

  Fly   423 QLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFS----NWISRYDESLVDPQVLHRLRYLSV 483
            .|.|..|:.|.|...:|...|.|..|.:....:|:.:    ..:|...|.|||
  Fly   396 YLKLGHNELKSLDVRMFAPMRRLQKLHLGHNLLEEINLDVLESLSSVQEILVD------------ 448

  Fly   484 QQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQISGLSRLQRLSVRGNSLGSLPENIKELRQ 548
              |.:||:| |.:..:.||                       |:|:::.
  Fly   449 --NNRLTFL-AKVNVSFPN-----------------------LKRVAIE---------------- 471

  Fly   549 LHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQIDALK 613
                   ||.:||.|.:. |..|||.      ..:...::::.....:.||....::|:.|..|:
  Fly   472 -------GNPWQCPCFVK-LQHWLAT------RDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQ 522

  Fly   614 C--QYGYRGD 621
            .  :.|..||
  Fly   523 AVRRLGILGD 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	4/21 (19%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_RI	<246..433	CDD:238064	64/193 (33%)
		LRR_8	251..311	CDD:290566	21/64 (33%)
		leucine-rich repeat	253..276	CDD:275380	1/22 (5%)
		leucine-rich repeat	277..300	CDD:275380	13/27 (48%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_8	325..383	CDD:290566	23/57 (40%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		LRR_RI	351..>557	CDD:238064	48/211 (23%)
		LRR_8	371..431	CDD:290566	21/61 (34%)
		leucine-rich repeat	373..396	CDD:275380	9/24 (38%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..444	CDD:275380	7/22 (32%)
		LRR_8	477..536	CDD:290566	9/58 (16%)
		leucine-rich repeat	478..502	CDD:275380	5/23 (22%)
		leucine-rich repeat	503..526	CDD:275380	0/22 (0%)
		Ig	<714..761	CDD:299845
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	46/183 (25%)
		LRR_8	104..164	CDD:290566	15/53 (28%)
		leucine-rich repeat	106..129	CDD:275380	7/17 (41%)
		leucine-rich repeat	130..153	CDD:275380	6/23 (26%)
		leucine-rich repeat	154..195	CDD:275380	7/40 (18%)
		LRR_RI	194..455	CDD:238064	94/313 (30%)
		LRR_8	194..254	CDD:290566	25/97 (26%)
		leucine-rich repeat	196..219	CDD:275380	6/28 (21%)
		leucine-rich repeat	220..243	CDD:275380	10/54 (19%)
		leucine-rich repeat	244..267	CDD:275380	13/23 (57%)
		LRR_8	271..330	CDD:290566	25/58 (43%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	319..380	CDD:290566	21/60 (35%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	9/24 (38%)
		LRR_8	368..428	CDD:290566	18/59 (31%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453569
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840