DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and Lrt

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	163/722 - (22%)
Similarity:	254/722 - (35%)	Gaps:	238/722 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 ADRSNPLKLPQLESLREFSWQSSELKDETLMELFTRQPRSFEYMERLNLAENRLEC--------- 217
            |::.:.|.||..::|.|  |:...:..       ||.            ||  |||
  Fly   113 AEQVSSLPLPVDDALME--WKCPNITG-------TRN------------AE--LECGCDLPHTLR 154

  Fly   218 ----LHWAIPLAVR-RVKVLEMSGNRLSNCSLLNLQYMKQ------------------------- 252
                ||..:.||.| |.....:|   |.:|||.|:.::..
  Fly   155 CNIDLHGMMLLADRLRTSPYSIS---LLDCSLRNVTFLSDAKIFDNVSLHGLVISSGEIKRVHKS 216

  Fly   253 --------LQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGN 309
                    ||.|.|..:.|..:|...|..||.|..|:|:.|.:..|....|||...|..|.||.|
  Fly   217 AFLGIRGPLQALGLPGNALMSVPWNALSTLSALERLDLANNKIKALGTADFVGLTSLVYLELSNN 281

  Fly   310 RLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNF--FARNGQLRQLHLQRNQLKS-IGKHSLYSLR 371
            ::|.:....|.....|:||.|..|||..:..:.  .::...||||.||.|.|.. :.:.:|..:|
  Fly   282 QISSISQRTFVNLRKLEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGPLSEQTLPGMR 346

  Fly   372 ELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPS 436
            .|..|:|::|.:..|..||..:...|::|::..|.:.:|....|..|.||..||||.|....:.|
  Fly   347 NLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGIVAISS 411

  Fly   437 GLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQVLHRLRYLSVQQN--RKLTYLPATLFAN 499
            ...|.                                 |.||..|.:..|  |.||   :.|.|.
  Fly   412 ASLQH---------------------------------LSRLTVLDLTHNFLRALT---SDLIAP 440

  Fly   500 TPNIRELLLAENGLLQLPTQISGLSRLQRLSVRGNSLGSLPENIKE-LRQLHYLNILGNEYQCDC 563
            .|::|||.||                       ||.:..:..|..: .|:|..|.:..|...|||
  Fly   441 LPSLRELRLA-----------------------GNDISIVARNAMDGARELESLQMQENPLSCDC 482

  Fly   564 SMYWLTAWLANTSTSLRHQMPQAQNHSNGSTN-------------QTPLD--------------- 600
            |:.....||           .::|.||:.|.:             |.|::
  Fly   483 SIRPFAEWL-----------QESQLHSSLSASCVTPPRLEGAPLLQVPVETLSCDMDNVEKDNAN 536

  Fly   601 --------------------SYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMH 645
                                |.|.|.|::. ....||.....|..|||.:.....:..:.|..::
  Fly   537 IMQHLETLAKPNQTSPIKDLSEEIILHELH-FSTDYGLILTWLLNLSKKDYMCDAIFVYKEEHIN 600

  Fly   646 K-LLSTAKLECQ---ISGSP-----VPD-------------IIWVTPR----------NKILR-H 677
            : |:..:.:.|:   ::|..     |||             ::.:..:          :.|.| .
  Fly   601 EILIDNSPIHCESKVVNGQNTVSVIVPDSSSLEIGESYRFCLVMIQEQKPDSELNIGCSNITRLE 665

  Fly   678 HADPDKRPIIIDSKEDAHQP-PSAQEL--AALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVH 739
            .:.|...|:   |::...:| .:|.||  ..:.|......:|..|.||:||.:....:..:|| |
  Fly   666 RSSPGAVPV---SRQYQRRPYYNANELKPEVVHDAGEDYQVNQRRFNSVVGSQPQQTQQSTLL-H 726

  Fly   740 NISRIDS 746
            :.:.|||
  Fly   727 SYTVIDS 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	10/35 (29%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_RI	<246..433	CDD:238064	62/222 (28%)
		LRR_8	251..311	CDD:290566	22/92 (24%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	21/60 (35%)
		leucine-rich repeat	325..348	CDD:275380	7/24 (29%)
		leucine-rich repeat	349..372	CDD:275380	9/23 (39%)
		LRR_RI	351..>557	CDD:238064	52/209 (25%)
		LRR_8	371..431	CDD:290566	21/59 (36%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	17/60 (28%)
		leucine-rich repeat	478..502	CDD:275380	8/25 (32%)
		leucine-rich repeat	503..526	CDD:275380	5/22 (23%)
		Ig	<714..761	CDD:299845	12/33 (36%)
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	50/185 (27%)
		leucine-rich repeat	179..199	CDD:275378	4/19 (21%)
		leucine-rich repeat	200..223	CDD:275380	0/22 (0%)
		leucine-rich repeat	225..248	CDD:275380	8/22 (36%)
		LRR_8	249..307	CDD:290566	20/57 (35%)
		leucine-rich repeat	249..272	CDD:275380	8/22 (36%)
		LRR_RI	<270..479	CDD:238064	69/267 (26%)
		leucine-rich repeat	273..296	CDD:275380	7/22 (32%)
		leucine-rich repeat	297..322	CDD:275380	7/24 (29%)
		LRR_8	322..382	CDD:290566	20/59 (34%)
		leucine-rich repeat	323..347	CDD:275380	9/23 (39%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		LRR_8	370..428	CDD:290566	19/90 (21%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	9/55 (16%)
		LRR_8	418..478	CDD:290566	22/85 (26%)
		leucine-rich repeat	420..443	CDD:275380	8/25 (32%)
		leucine-rich repeat	444..467	CDD:275380	8/45 (18%)
		LRRCT	476..526	CDD:214507	13/60 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010