DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and Lrrc24

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001129368.1	Gene:	Lrrc24 / 362945	RGDID:	1308720	Length:	521	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	124/546 - (22%)
Similarity:	187/546 - (34%)	Gaps:	171/546 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 LHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQ 416
            |.||.|.:..:.:.:|..|..||.|.|..|:|..::..||.:...||.|.::||.|..|....|.
  Rat    63 LFLQDNSIAHLEQGALAPLAALRHLYLHNNTLRALESGAFRAQPRLLELALTGNRLRGLRGGAFV 127

  Fly   417 SLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQVLHRLRYL 481
            .|..||.|.|:.||..:|               :|.|
  Rat   128 GLVQLRVLYLAGNQLAKL---------------LDFT---------------------------- 149

  Fly   482 SVQQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQ-ISGLSRLQRLSVRGNSLGSL-PENIK 544
                           |.:.|.::||.|.||.:..|..| ::|||.|..|.:..|.||:: .|.::
  Rat   150 ---------------FLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISKEALQ 199

  Fly   545 ELRQLHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQI 609
            .|..|..|.:..|.::|||:::||.:|:......|                      ..|.|.:|
  Rat   200 PLSSLQVLRLTENPWRCDCALHWLGSWIKEGGRRL----------------------LSSRDKKI 242

  Fly   610 DALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLLSTAKL------ECQISGSPVPDIIWV 668
            ...:........:|.|.......:|..|....|::     ||.|      .||.||.|.|.::|
  Rat   243 TCAEPPRLALQSLLEVSGGSLICIPPSVNAEPPEL-----TANLGEDLQVACQASGYPQPLVVW- 301

  Fly   669 TPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSL--NWTRQNSLVGRRVVLV 731
               .|:|                    ||...:..|.:..|.....|  :.||...
  Rat   302 ---RKML--------------------QPRDGKPQAQVQLEGGAPGLGGHATRDTG--------- 334

  Fly   732 ENGSLLVHNISRIDSGLYTCYAFNVMGKASAGLRLYIDPIVFYRVKI------------------ 778
             :|.|.:.||:...:|.|.|.|.|..|||.....|.::.......::
  Rat   335 -SGMLFLTNITLAHAGKYECEATNAGGKARVLFHLLVNASRQQSQQLPAPQAPATRPVGQEPQHE 398

  Fly   779 -GSILF-------GTALATAFLLLTLIVQGLRSCLSRWGICNRFYCCVNRKKKSPRKHQIYAMLD 835
             ||:.|       .||:..|..||.|....|.:.     ||.|    ..|:||.|.......:.
  Rat   399 GGSMAFRALGLATQTAITAAIALLALTALLLAAM-----ICRR----RRRRKKMPVPSGEGTLF- 453

  Fly   836 SIETYKS-----QQLERLRENYTQQV 856
             :..|..     .|||.||:::..::
  Rat   454 -VNDYSDGPCTFAQLEELRDDHGHEM 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	29/80 (36%)
		LRR_8	251..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		leucine-rich repeat	301..324	CDD:275380
		LRR_8	325..383	CDD:290566	11/30 (37%)
		leucine-rich repeat	325..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380	6/19 (32%)
		LRR_RI	351..>557	CDD:238064	53/206 (26%)
		LRR_8	371..431	CDD:290566	22/59 (37%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	9/22 (41%)
		leucine-rich repeat	421..444	CDD:275380	7/22 (32%)
		LRR_8	477..536	CDD:290566	15/59 (25%)
		leucine-rich repeat	478..502	CDD:275380	1/23 (4%)
		leucine-rich repeat	503..526	CDD:275380	10/23 (43%)
		Ig	<714..761	CDD:299845	14/48 (29%)
Lrrc24	NP_001129368.1	leucine-rich repeat	61..83	CDD:275380	6/19 (32%)
		PPP1R42	63..>212	CDD:411060	53/206 (26%)
		LRR_8	84..142	CDD:404697	22/57 (39%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		leucine-rich repeat	132..155	CDD:275380	10/80 (13%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		PCC	188..>259	CDD:188093	19/92 (21%)
		Ig_3	267..357	CDD:404760	30/128 (23%)
		Ig strand A	267..271	CDD:409353	1/3 (33%)
		Ig strand A'	276..280	CDD:409353	1/8 (13%)
		Ig strand B	283..292	CDD:409353	2/8 (25%)
		Ig strand C	298..304	CDD:409353	1/9 (11%)
		Ig strand D	330..333	CDD:409353	2/2 (100%)
		Ig strand E	336..342	CDD:409353	2/5 (40%)
		Ig strand F	349..357	CDD:409353	4/7 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000