DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and rdo

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	144/687 - (20%)
Similarity:	250/687 - (36%)	Gaps:	224/687 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 RSFEYMERLNLAENRLECL----HWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELHLDR 260
            |.|..:|.|.:.::.|..:    .|.:    :.:::|::|.|.::|.:..|.:....|.||.|.:
  Fly    79 RQFMKLEILRITDSNLPAIGAESFWGL----KYLRILDLSKNNITNITENNFRGQDNLLELDLSK 139

  Fly   261 SELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADL 325
            :::..:.......|::||.|||:.|.:.||.:..|....:|:.|.||||.|..|...:|:...:|
  Fly   140 NKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPEL 204

  Fly   326 QVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRE-LRQLDLSQNSLSVIDRK 389
            :||.              .||.||::::.|           :|:|.. |.:|||.:|....:|:.
  Fly   205 KVLK--------------CRNCQLKKINPQ-----------MYNLLPLLSELDLGRNEFKFLDKD 244

  Fly   390 AFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLV-------- 446
            .|..:..|..:.:.||.|:::...:|:...:|..||||.|:..::|:..|.:..:|.
  Fly   245 EFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNK 309

  Fly   447 LLRIDETPIEQFSNWISRYDESLVDPQVLHRLRYLSVQQNRKLTYLPAT----LFANTPNIRELL 507
            |:|::...|...||.::..    :...||..||.:.......:.|...|    .|...|.:..|.
  Fly   310 LVRLEPQSIRSLSNLLTLN----ISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLA 370

  Fly   508 LAENGLLQLPTQISGLSRLQRLSVRGNSLGSLPENIKELRQLHYLNILGNEYQCDCSMYWLTAWL 572
            :|:.|.:.:     ||                   :...:||.||||.||
  Fly   371 IADMGTMPV-----GL-------------------LHPFKQLRYLNISGN--------------- 396

  Fly   573 ANTSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVV 637
                                |.|.|.|   |.||                       .|.....:
  Fly   397 --------------------SLNNTAL---EVID-----------------------PCRELEFL 415

  Fly   638 QFSEPKMHKLLSTAKLECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQE 702
            ..|..::|.:.....|  :|.|.          ||..|      |..|:|.|   :.|
  Fly   416 DLSRNQLHGISEDTVL--RIQGI----------RNVRL------DNNPLICD---ECH------- 452

  Fly   703 LAALMDESYIQSLNWT--------RQNSLVGRRVVLVENGSLLVHNISRID-SGLYTCYAFNVMG 758
            :..|:  :.::.|.|.        ...||.|.             .|:.:| :||:||..|....
  Fly   453 MGKLI--NVVRQLQWKWDTYPICFLPKSLRGA-------------EINNLDINGLHTCLTFITDE 502

  Fly   759 KASAGLRLY-------IDPIVFYRVKIGSILFGTALATAFLLLTLIVQGLRSCLSRWGICNRFYC 816
            :.:|....|       ::.:..    :|.|:        |:|:.:|:..|.:|.|:
  Fly   503 EQNAASTSYNFLEHGGLNTLAI----LGGII--------FVLIAVIILSLVACFSK--------- 546

  Fly   817 CVNRKKKSPRKHQIYAMLDSIETYKSQQLERLRENYT 853
              ||.:       .|...|.:...:|:.||:..|..|
  Fly   547 --NRAR-------YYTREDHLNGSESKCLEKNLEATT 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	4/25 (16%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_RI	<246..433	CDD:238064	52/187 (28%)
		LRR_8	251..311	CDD:290566	20/59 (34%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_8	325..383	CDD:290566	15/58 (26%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		LRR_RI	351..>557	CDD:238064	48/218 (22%)
		LRR_8	371..431	CDD:290566	18/60 (30%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	5/22 (23%)
		leucine-rich repeat	421..444	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	11/62 (18%)
		leucine-rich repeat	478..502	CDD:275380	5/27 (19%)
		leucine-rich repeat	503..526	CDD:275380	5/22 (23%)
		Ig	<714..761	CDD:299845	12/55 (22%)
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	4/26 (15%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_8	131..190	CDD:290566	20/58 (34%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		LRR_RI	151..422	CDD:238064	85/384 (22%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		LRR_8	178..262	CDD:290566	29/108 (27%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..251	CDD:275380	17/71 (24%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	274..334	CDD:290566	14/63 (22%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		LRR_4	298..342	CDD:289563	10/47 (21%)
		leucine-rich repeat	300..323	CDD:275380	4/22 (18%)
		leucine-rich repeat	388..411	CDD:275380	15/83 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940