DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and kek2

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	110/560 - (19%)
Similarity:	189/560 - (33%)	Gaps:	201/560 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 GNRLSVLPFMLFQTAAD--LQVLDLSDNRLLSFPDNFFARNG--QLRQLHLQRNQLKSIGKHSLY 368
            |.:||.||     ...|  .|||:.|.|.|.......|.|..  .|::::|.||||..|.:.:..
  Fly    40 GQQLSNLP-----EGMDPGTQVLNFSGNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFR 99

  Fly   369 SLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQ 433
            .|..|.:||||:|:|..:..:.|:....|:.|::|||.:..|.:..|:.|..|..|:||..|
  Fly   100 GLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQ--- 161

  Fly   434 LPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQVLHRLRYLSVQQNRKLTYLPATLFA 498
                                 :|:..|      |:.|
  Fly   162 ---------------------VERIEN------EAFV---------------------------- 171

  Fly   499 NTPNIRELLLAENGLLQLPTQISGLSRLQRLSVRGNSLGSLPENIKELRQLHYLNILGNEYQCDC 563
                                   |:..|:.|.:.||.:|.:.......:.||.:::..|.:.|||
  Fly   172 -----------------------GMDNLEWLRLDGNRIGFIQGTHILPKSLHGISLHSNRWNCDC 213

  Fly   564 SMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYR--GDMLRVL 626
            .:..:..||.|.:|.|..:.                             ||....|  |.:::.|
  Fly   214 RLLDIHFWLVNYNTPLAEEP-----------------------------KCMEPARLKGQVIKSL 249

  Fly   627 SK--LNCSVPTV------VQFSEPKMHKLLSTAKLECQISGSPVPDIIWVTPRNKILRHHADPDK 683
            .:  |.| :|.|      .:.||.:      ...:.|.:...|.|.::|:. ..:::.:
  Fly   250 QREQLAC-LPEVSPQSSYTEVSEGR------NMSITCLVRAIPEPKVLWLF-NGQVMSN------ 300

  Fly   684 RPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDSGL 748
                 ||               |||..::    :...:..:|......:...:.::|:...|:|.
  Fly   301 -----DS---------------LMDNLHM----YYYIDETIGVSGAEEKRSEIFIYNVGAEDNGT 341

  Fly   749 YTCYAFNVMGKASAG--LRLYI-DPIVFYRVKI--------------GSILFGTALATAFLLLTL 796
            ::|...|:.|...:.  ||:.| :|.|...|..              |.|:|      ..||.|:
  Fly   342 FSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSFPRDYMNYIVASSAGGGIIF------VVLLCTI 400

  Fly   797 IVQGLRSCLSRWGICNRFYCCVNRKKKSPRKHQIYAMLDS 836
            :|:           |.:......::||..:...|....||
  Fly   401 VVK-----------CKKTSEPAKQRKKCDQVTSIAGGTDS 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	43/128 (34%)
		LRR_8	251..311	CDD:290566	1/2 (50%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		leucine-rich repeat	301..324	CDD:275380	5/15 (33%)
		LRR_8	325..383	CDD:290566	22/59 (37%)
		leucine-rich repeat	325..348	CDD:275380	8/24 (33%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		LRR_RI	351..>557	CDD:238064	40/205 (20%)
		LRR_8	371..431	CDD:290566	20/59 (34%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..444	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	5/58 (9%)
		leucine-rich repeat	478..502	CDD:275380	0/23 (0%)
		leucine-rich repeat	503..526	CDD:275380	1/22 (5%)
		Ig	<714..761	CDD:299845	7/46 (15%)
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/16 (31%)
		leucine-rich repeat	54..79	CDD:275380	8/24 (33%)
		LRR_8	79..138	CDD:290566	21/58 (36%)
		LRR_RI	<80..187	CDD:238064	38/187 (20%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	22/140 (16%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	10/103 (10%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		TPKR_C2	207..256	CDD:301599	15/77 (19%)
		I-set	258..361	CDD:254352	21/139 (15%)
		Ig_2	263..361	CDD:290606	19/134 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010