DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and Lingo1

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	147/625 - (23%)
Similarity:	225/625 - (36%)	Gaps:	136/625 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 DRSELTYLPQRFL----GELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLF 319
            ||:.|.: .:||:    |..:|.|:|:|.:|.:..|.:|.|.....||.|.|:.|.:|.:....|
  Rat    52 DRAVLCH-RKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAF 115

  Fly   320 QTAADLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLS 384
            ....:|:.|.|..|||...|...|.....|.:|.:..|::..:..:....|..|:.|::..|.|.
  Rat   116 NNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 180

  Fly   385 VIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLR 449
            .|..:||..|:.|..|.:...|||.:.:.....||.|..|.|.......:....|:|...|.:|.
  Rat   181 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLE 245

  Fly   450 IDETPIEQFSNWISRYDESLVDPQVLH----RLRYLSVQQNRKLTYLPATLFANTP-------NI 503
            |...|..........|..:|....:.|    .:.||:|   |.|.||.....:..|       .:
  Rat   246 ISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAV---RHLVYLRFLNLSYNPIGTIEGSML 307

  Fly   504 RELLLAENGLLQL---------PTQISGLSRLQRLSVRGNSLGSLPEN-IKELRQLHYLNILGNE 558
            .|||..:.  :||         |....||:.|:.|:|.||.|.:|.|: ...:..|..|.:..|.
  Rat   308 HELLRLQE--IQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNP 370

  Fly   559 YQCDCSMYWL--TAWLANTSTSLRHQMPQAQNHSNGSTNQTP--LDSYESIDHQIDAL-----KC 614
            ..|||.:.|:  ..|..|    ...|.|         |..||  :...|..|.. |.|     .|
  Rat   371 LACDCRLLWVFRRRWRLN----FNRQQP---------TCATPEFVQGKEFKDFP-DVLLPNYFTC 421

  Fly   615 QYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLLSTAKLECQISGSPVPDIIWVTPRNKILRHHA 679
            :..:..|  |...::.......|||              .|:..|.|.|.|:|::||    :|
  Rat   422 RRAHIRD--RKAQQVFVDEGHTVQF--------------VCRADGDPPPAILWLSPR----KH-- 464

  Fly   680 DPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRI 744
                   ::.:|.:.                                |:.:..:|:|.|......
  Rat   465 -------LVSAKSNG--------------------------------RLTVFPDGTLEVRYAQVQ 490

  Fly   745 DSGLYTCYAFNVMGKASAGLRLYI------------DPIVFYRVKIGSILFGTALATA---FLLL 794
            |:|.|.|.|.|..|..|....|::            ....|...:.|.....:..||.   |.:.
  Rat   491 DNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIK 555

  Fly   795 TLIVQGLRSCLSRWGICNRFYCCVN----RKKKSPRKHQI 830
            |||:......:|..|:.  .:|.|.    .:.|...||.|
  Rat   556 TLIIATTMGFISFLGVV--LFCLVLLFLWSRGKGNTKHNI 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	51/177 (29%)
		LRR_8	251..311	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	6/20 (30%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	15/57 (26%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		LRR_RI	351..>557	CDD:238064	56/226 (25%)
		LRR_8	371..431	CDD:290566	18/59 (31%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	21/74 (28%)
		leucine-rich repeat	478..502	CDD:275380	8/30 (27%)
		leucine-rich repeat	503..526	CDD:275380	8/31 (26%)
		Ig	<714..761	CDD:299845	11/46 (24%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	7/23 (30%)
		LRR	<66..371	CDD:227223	82/309 (27%)
		leucine-rich repeat	73..96	CDD:275380	7/22 (32%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		LRR_8	120..179	CDD:404697	15/58 (26%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		leucine-rich repeat	145..192	CDD:275380	12/46 (26%)
		leucine-rich repeat	193..216	CDD:275380	6/22 (27%)
		leucine-rich repeat	217..264	CDD:275380	10/46 (22%)
		leucine-rich repeat	265..288	CDD:275380	7/25 (28%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		leucine-rich repeat	313..336	CDD:275380	5/24 (21%)
		leucine-rich repeat	337..357	CDD:275380	8/19 (42%)
		PCC	341..>421	CDD:188093	24/93 (26%)
		IgI_Lingo-1	423..514	CDD:409561	28/151 (19%)
		Ig strand B	442..446	CDD:409561	3/17 (18%)
		Ig strand C	455..459	CDD:409561	1/3 (33%)
		Ig strand E	480..484	CDD:409561	2/3 (67%)
		Ig strand F	494..499	CDD:409561	2/4 (50%)
		Ig strand G	507..510	CDD:409561	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920